Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Frank O, Nestle"'
Autor:
Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec
Externí odkaz:
https://doaj.org/article/eeac938a111045e186e031edbfe48da6
Autor:
Prudence PokWai Lui, Chrysanthi Ainali, Chung-Ching Chu, Manuela Terranova-Barberio, Panagiotis Karagiannis, Angela Tewari, Niloufar Safinia, Ehsan Sharif-Paghaleh, Sophia Tsoka, Grzegorz Woszczek, Paola Di Meglio, Giovanna Lombardi, Antony R. Young, Frank O. Nestle, Niwa Ali
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108029- (2023)
Summary: Skin immune homeostasis is a multi-faceted process where dermal dendritic cells (DDCs) are key in orchestrating responses to environmental stressors. We have previously identified CD141+CD14+ DDCs as a skin-resident immunoregulatory populati
Externí odkaz:
https://doaj.org/article/bfb8903d33a541d1b9febee12c9327fb
Autor:
Rosa Andres-Ejarque, Hira Bahadur Ale, Katarzyna Grys, Isabella Tosi, Shane Solanky, Chrysanthi Ainali, Zeynep Catak, Hemawtee Sreeneebus, Jake Saklatvala, Nick Dand, Emanuele de Rinaldis, Anna Chapman, Frank O. Nestle, Michael R. Barnes, Richard B. Warren, Nick J. Reynolds, Christopher E. M. Griffiths, Jonathan N. Barker, Catherine H. Smith, Paola Di Meglio, the PSORT Consortium
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Biomarkers to indicate potential response to biologic therapeutics are needed for patients with psoriasis. Here the authors show that phosphorylation of NFκBp65 in cDC2 before therapy is an indication of non-response to the anti-TNF therapy adalimum
Externí odkaz:
https://doaj.org/article/5f76b87e60c641cb804dbde9f569fb55
Autor:
Nanna Fyhrquist, Gareth Muirhead, Stefanie Prast-Nielsen, Marine Jeanmougin, Peter Olah, Tiina Skoog, Gerome Jules-Clement, Micha Feld, Mauricio Barrientos-Somarribas, Hanna Sinkko, Ellen H. van den Bogaard, Patrick L.J.M. Zeeuwen, Gijs Rikken, Joost Schalkwijk, Hanna Niehues, Walter Däubener, Silvia Kathrin Eller, Helen Alexander, Davide Pennino, Sari Suomela, Ioannis Tessas, Emilia Lybeck, Anna M. Baran, Hamid Darban, Roopesh Singh Gangwar, Ulrich Gerstel, Katharina Jahn, Piia Karisola, Lee Yan, Britta Hansmann, Shintaro Katayama, Stephan Meller, Max Bylesjö, Philippe Hupé, Francesca Levi-Schaffer, Dario Greco, Annamari Ranki, Jens M. Schröder, Jonathan Barker, Juha Kere, Sophia Tsoka, Antti Lauerma, Vassili Soumelis, Frank O. Nestle, Bernhard Homey, Björn Andersson, Harri Alenius
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Atopic dermatitis (AD) and psoriasis (PSO) are associated with dysbiosis. Here, by analyses of skin microbiome and host transcriptome of AD and PSO patients, the authors find distinct microbial and disease-related gene transcriptomic signatures that
Externí odkaz:
https://doaj.org/article/801d353e9aec45f68391d2416fdff3f4
Autor:
Rosa Andres-Ejarque, Hira Bahadur Ale, Katarzyna Grys, Isabella Tosi, Shane Solanky, Chrysanthi Ainali, Zeynep Catak, Hemawtee Sreeneebus, Jake Saklatvala, Nick Dand, Emanuele de Rinaldis, Anna Chapman, Frank O. Nestle, Michael R. Barnes, Richard B. Warren, Nick J. Reynolds, Christopher E. M. Griffiths, Jonathan N. Barker, Catherine H. Smith, Paola Di Meglio, the PSORT Consortium
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/b58d8c68c05b44b29b1d31cc2c9b5e85
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Both genetics and environment affect the number and phenotype of immune cells. Here the authors characterize the degree of influence of genetics versus environment on various immune cell parameters by analysing a large cohort of female twins.
Externí odkaz:
https://doaj.org/article/16f6257f95c540d1a3c35d6f7b891095
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
Evaluation of FRalpha expression by tumor cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38db7cb9edccc92a72b16204c6c84d78
https://doi.org/10.1158/0008-5472.22416014.v1
https://doi.org/10.1158/0008-5472.22416014.v1
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
Table of Patient Characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae24e70842a424500fbe06f48794886
https://doi.org/10.1158/0008-5472.22416008.v1
https://doi.org/10.1158/0008-5472.22416008.v1
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
IgE antibodies are key mediators of antiparasitic immune responses, but their potential for cancer treatment via antibody-dependent cell-mediated cytotoxicity (ADCC) has been little studied. Recently, tumor antigen–specific IgEs were reported to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816bd38045ed7ffde480f7e6dc0d11ea
https://doi.org/10.1158/0008-5472.c.6509447.v1
https://doi.org/10.1158/0008-5472.c.6509447.v1
Autor:
Sophia N. Karagiannis, Andrew N.J. Tutt, Anita Grigoriadis, James F. Spicer, Cheryl Gillett, Frank O. Nestle, Sarah Pinder, Mariangela Figini, Silvana Canevari, Debra H. Josephs, Daniel Larcombe-Young, Gyula Petranyi, Silvia Crescioli, Heather J. Bax, Giulia Pellizzari, Silvia Mele, Nirmesh Patel, Luned Badder, Angela Clifford, Diana Dominguez Rodriguez, Matthew Fittall, Erika Francesch-Domenech, Rebecca Marlow, Hasan Mirza, Ricarda M. Hoffmann, Patrycja Gazinska, Kristina M. Ilieva, James Opzoomer, Anthony Cheung
Purpose: Highly aggressive triple-negative breast cancers (TNBCs) lack validated therapeutic targets and have high risk of metastatic disease. Folate receptor alpha (FRα) is a central mediator of cell growth regulation that could serve as an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeced1d042d1dc7c01723a2468cd543
https://doi.org/10.1158/1078-0432.c.6529226
https://doi.org/10.1158/1078-0432.c.6529226