Zobrazeno 1 - 10 of 103 pro vyhledávání: '"Frank N. Gellerich"'
1
Akademický článek
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology
Autor: Marten Szibor, Praveen K. Dhandapani, Eric Dufour, Kira M. Holmström, Yuan Zhuang, Isabelle Salwig, Ilka Wittig, Juliana Heidler, Zemfira Gizatullina, Timur Gainutdinov, German Mouse Clinic Consortium, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Jatin Nandania, Vidya Velagapudi, Astrid Wietelmann, Pierre Rustin, Frank N. Gellerich, Howard T. Jacobs, Thomas Braun
Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 2, Pp 163-171 (2017)
Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow
Externí odkaz: https://doaj.org/article/723f62cecb1f4bc78341cbec0e109669
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2
Akademický článek
Mitochondria and Energetic Depression in Cell Pathophysiology
Autor: Stephan Zierz, Katharina Jegorov, Maria Sonnabend, Doreen Jerzembeck, Odeta Arandarcikaite, Sonata Trumbeckaite, Manfred H.P. Wussling, Stefan Vielhaber, Huu Phuc Nguyen, Zemfira Gizatullina, Ants Peetsalu, Marju Gruno, Enn Seppet, Frank Striggow, Frank N. Gellerich
Publikováno v: International Journal of Molecular Sciences, Vol 10, Iss 5, Pp 2252-2303 (2009)
Mitochondrial dysfunction is a hallmark of almost all diseases. Acquired or inherited mutations of the mitochondrial genome DNA may give rise to mitochondrial diseases. Another class of disorders, in which mitochondrial impairments are initiated by e
Externí odkaz: https://doaj.org/article/69a60e2cbcee48549f155ed44cb9307d
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3
Impairment of mitochondrial oxidative phosphorylation in skin fibroblasts of SALS and FALS patients is rescued by in vitro treatment with ROS scavengers
Autor: Stefanie Schreiber, Jarosław Walczak, Irina Miller, Werner Zuschratter, Joanna Szczepanowska, Wolfram S. Kunz, Susanne Petri, Grazyna Debska-Vielhaber, Viktoriya Peeva, Frank N. Gellerich, Judith Machts, Andreas Hermann, Stefan Vielhaber, Susanne Vogt
Publikováno v: Experimental neurology 339, 113620-(2021). doi:10.1016/j.expneurol.2021.113620
Amyotrophic lateral sclerosis (ALS) is a devastating, rapidly progressive, neurodegenerative disorder affecting upper and lower motor neurons. Approximately 10% of patients suffer from familial ALS (FALS) with mutations in different ubiquitously expr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ce0239394b8543c6e3988a83fae206
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6
Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply
Autor: Thomas Endres, Stefan Vielhaber, Kerstin Hallmann, Niki Karavasili, Marten Szibor, Frank Schreiber, T. M. Gainutdinov, Volkmar Lessmann, Michael Schwarzer, Zemfira Gizatullina, Torsten Doenst, Matthias Kunz, Wolfram S. Kunz, Grazyna Debska-Vielhaber, Frank N. Gellerich, Alexandra Bamberger, Hans-Jochen Heinze
Publikováno v: The journal of biological chemistry 295(14), 4383-4397 (2020). doi:10.1074/jbc.RA119.011902
The journal of biological chemistry, 295(14):4383-4397
The Journal of Biological Chemistry
Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3d6448d2f54ea5c8e34997c143a0fa
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7
Reply to Rutter et al.: The roles of cytosolic and intramitochondrial Ca2+ and the mitochondrial Ca2+-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation
Autor: Michael Schwarzer, Volkmar Lessmann, Wolfram S. Kunz, Torsten Doenst, Marten Szibor, Frank N. Gellerich, Stefan Vielhaber, Zemfira Gizatullina
Publikováno v: J Biol Chem
JBC papers in press 295(30), 10507-10507 (2020). doi:10.1074/jbc.RL120.014342
Each model used in the work referred to by Rutter et al. (1) addressed certain aspects of mitochondrial biology, and together, they fully support the conclusions made. Please note that we describe Ca2+-mediated regulation of oxidative phosphorylation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06eaff5d16335be81bddca69bab2a0d2
https://doi.org/10.1074/jbc.rl120.014342
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8
Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: Switch from RET and ROS to FET
Autor: Marten Szibor, T. M. Gainutdinov, Erika Fernandez-Vizarra, Ilka Wittig, Grazyna Debska-Vielhaber, Frank N. Gellerich, Juliana Heidler, Eric Dufour, Anthony L. Moore, Carlo Viscomi, Zemfira Gizatullina
Publikováno v: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1861:148137
Electron transfer from all respiratory chain dehydrogenases of the electron transport chain (ETC) converges at the level of the quinone (Q) pool. The Q redox state is thus a function of electron input (reduction) and output (oxidation) and closely re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d07e17bf5346c8396998d01dbd66c5
https://doi.org/10.1016/j.bbabio.2019.148137
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9
Knockout of cyclophilin D in Ppif−/− mice increases stability of brain mitochondria against Ca2+ stress
Autor: Grazyna Debska-Vielhaber, Jeffery D. Molkentin, Detlef Siemen, T. Gainutdinov, Frank N. Gellerich, Zulfiya Orynbayeva, Zemfira Gizatullina, S. Vielhaber, M. Ziemer
Publikováno v: Archives of Biochemistry and Biophysics. 579:40-46
The mitochondrial peptidyl prolyl isomerase cyclophilin D (CypD) activates permeability transition (PT). To study the role of CypD in this process we compared the functions of brain mitochondria isolated from wild type (BMWT) and CypD knockout (Ppif(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::633f28fff118b749b4fe7948126cb70e
https://doi.org/10.1016/j.abb.2015.05.009
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10
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology
Autor: Kira M. Holmström, Valerie Gailus-Durner, Martin Hrabě de Angelis, Howard T. Jacobs, Eric Dufour, Ilka Wittig, Jatin Nandania, Marten Szibor, T. M. Gainutdinov, Pierre Rustin, Thomas Braun, Isabelle Salwig, Frank N. Gellerich, Juliana Heidler, Yuan Zhuang, Vidya Velagapudi, Zemfira Gizatullina, Helmut Fuchs, Astrid Wietelmann, Praveen K. Dhandapani
Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 2, Pp 163-171 (2017)
Disease models & mechanisms, 10(2): 163-171
Disease Models & Mechanisms
Dis. Model. Mech. 10, 163-171 (2017)
Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932cee2f61f1e1333fa77f49c3a6201f
http://hdl.handle.net/10138/178992
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