Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Frank N van Leeuwen"'
Autor:
Esther Tijchon, Dorette van Ingen Schenau, Fred van Opzeeland, Felice Tirone, Peter M Hoogerbrugge, Frank N Van Leeuwen, Blanca Scheijen
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131481 (2015)
Btg1 and Btg2 encode highly homologous proteins that are broadly expressed in different cell lineages, and have been implicated in different types of cancer. Btg1 and Btg2 have been shown to modulate the function of different transcriptional regulato
Externí odkaz:
https://doaj.org/article/99908c2bce9342849a4752f2671e8943
Autor:
Melanie M Hagleitner, Marieke J H Coenen, Ana Patino-Garcia, Eveline S J M de Bont, Anna Gonzalez-Neira, Hanneke I Vos, Frank N van Leeuwen, Hans Gelderblom, Peter M Hoogerbrugge, Henk-Jan Guchelaar, Maroeska W M Te Loo
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115869 (2014)
Treatment with cisplatin-containing chemotherapy regimens causes hearing loss in 40-60% of cancer patients. It has been suggested that genetic variants in the genes encoding thiopurine S-methyltransferase (TPMT) and catechol O-methyltransferase (COMT
Externí odkaz:
https://doaj.org/article/fdf17208af2841b584635def623c0bcb
IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia
Autor:
Britt M. T. Vervoort, Miriam Butler, Kari J.T. Grünewald, Dorette S. van Ingen Schenau, Trisha M. Tee, Luc Lucas, Alwin D. R. Huitema, Judith M. Boer, Beat C. Bornhauser, Jean-Pierre Bourquin, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
IKZF1-deletions occur in 10-15% of patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and predict a poor outcome. However, the impact of IKZF1-loss on sensitivity to drugs used in contemporary treatment protocols has remained under
Externí odkaz:
https://doaj.org/article/70f5749bff5943bb9814e9df3159f0f2
Autor:
Gordan Lauc, Jennifer E Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Leslie Patrick, Paul McKeigue, Ivana Kolčić, Ivan Krešimir Lukić, Olivia Swann, Frank N van Leeuwen, L Renee Ruhaak, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Marian Beekman, Anton J M de Craen, André M Deelder, Qiang Zeng, Wei Wang, Nicholas D Hastie, Ulf Gyllensten, James F Wilson, Manfred Wuhrer, Alan F Wright, Pauline M Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell, Igor Rudan
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003225 (2013)
Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG
Externí odkaz:
https://doaj.org/article/b199e4ae942e4dc2a7fbc3d1609faf09
Autor:
Esmé Waanders, Blanca Scheijen, Laurens T van der Meer, Simon V van Reijmersdal, Liesbeth van Emst, Yvet Kroeze, Edwin Sonneveld, Peter M Hoogerbrugge, Ad Geurts van Kessel, Frank N van Leeuwen, Roland P Kuiper
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002533 (2012)
Recurrent submicroscopic deletions in genes affecting key cellular pathways are a hallmark of pediatric acute lymphoblastic leukemia (ALL). To gain more insight into the mechanism underlying these deletions, we have studied the occurrence and nature
Externí odkaz:
https://doaj.org/article/e9d7e52f51aa42f59b59e9ea3e9b9e39
Autor:
Jan W P Kuiper, Helma Pluk, Frank Oerlemans, Frank N van Leeuwen, Frank de Lange, Jack Fransen, Bé Wieringa
Publikováno v:
PLoS Biology, Vol 6, Iss 3, p e51 (2008)
Phagocytosis requires locally coordinated cytoskeletal rearrangements driven by actin polymerization and myosin motor activity. How this actomyosin dynamics is dependent upon systems that provide access to ATP at phagosome microdomains has not been d
Externí odkaz:
https://doaj.org/article/9f056063e56d4e82ac8a42edc20fa5ed
Autor:
Kristopher Clark, Jeroen Middelbeek, Nick A Morrice, Carl G Figdor, Edwin Lasonder, Frank N van Leeuwen
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1876 (2008)
TRPM6 and TRPM7 are bifunctional proteins expressing a TRP channel fused to an atypical alpha-kinase domain. While the gating properties of TRPM6 and TRPM7 channels have been studied in detail, little is known about the mechanisms regulating kinase a
Externí odkaz:
https://doaj.org/article/7698f9dc761844ae84244a5b619b0d9f
Autor:
Annelienke M. van Hulst, Jordy C.G. van der Zwet, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Marta Fiocco, Rob Pieters, Frank N. van Leeuwen, Marry M. van den Heuvel-Eibrink, Erica L.T. van den Akker, Jules P.P. Meijerink
Publikováno v:
Haematologica, Vol 109, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/579ba24a9a684d72832907d8045d45c9
Autor:
Willem P.J. Cox, Nils Evander, Dorette S. van Ingen Schenau, Gawin R. Stoll, Nadia Anderson, Lieke de Groot, Kari J.T. Grünewald, Rico Hagelaar, Miriam Butler, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
In pediatric acute lymphoblastic leukemia (ALL), mutations/deletions affecting the TP53 gene are rare at diagnosis. However, at relapse about 12% of patients show TP53 aberrations, which are predictive of a very poor outcome. Since p53-mediated apopt
Externí odkaz:
https://doaj.org/article/986ac4b3aae24d9999fc92fcd6366f17
Autor:
Anna Østergaard, Amir Enshaei, Rob Pieters, Ajay Vora, Martin A. Horstmann, Gabriele Escherich, Bertil Johansson, Mats Heyman, Kjeld Schmiegelow, Peter M. Hoogerbrugge, Monique L. den Boer, Roland P. Kuiper, Anthony V. Moorman, Judith M. Boer, Frank N. van Leeuwen
Publikováno v:
HemaSphere, Vol 7, Iss 5, p e875 (2023)
IKZF1 deletions are an established prognostic factor in childhood acute lymphoblastic leukemia (ALL). However, their relevance in patients with good risk genetics, namely ETV6::RUNX1 and high hyperdiploid (HeH), ALL remains unclear. We assessed the p
Externí odkaz:
https://doaj.org/article/5645c5c18f97430d84ab7aaaba94a6bf