Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Frank N, van Leeuwen"'
IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia
Autor:
Britt M. T. Vervoort, Miriam Butler, Kari J.T. Grünewald, Dorette S. van Ingen Schenau, Trisha M. Tee, Luc Lucas, Alwin D. R. Huitema, Judith M. Boer, Beat C. Bornhauser, Jean-Pierre Bourquin, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
IKZF1-deletions occur in 10-15% of patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and predict a poor outcome. However, the impact of IKZF1-loss on sensitivity to drugs used in contemporary treatment protocols has remained under
Externí odkaz:
https://doaj.org/article/70f5749bff5943bb9814e9df3159f0f2
Autor:
Annelienke M. van Hulst, Jordy C.G. van der Zwet, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Marta Fiocco, Rob Pieters, Frank N. van Leeuwen, Marry M. van den Heuvel-Eibrink, Erica L.T. van den Akker, Jules P.P. Meijerink
Publikováno v:
Haematologica, Vol 109, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/579ba24a9a684d72832907d8045d45c9
Autor:
Willem P.J. Cox, Nils Evander, Dorette S. van Ingen Schenau, Gawin R. Stoll, Nadia Anderson, Lieke de Groot, Kari J.T. Grünewald, Rico Hagelaar, Miriam Butler, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
In pediatric acute lymphoblastic leukemia (ALL), mutations/deletions affecting the TP53 gene are rare at diagnosis. However, at relapse about 12% of patients show TP53 aberrations, which are predictive of a very poor outcome. Since p53-mediated apopt
Externí odkaz:
https://doaj.org/article/986ac4b3aae24d9999fc92fcd6366f17
Autor:
Anna Østergaard, Amir Enshaei, Rob Pieters, Ajay Vora, Martin A. Horstmann, Gabriele Escherich, Bertil Johansson, Mats Heyman, Kjeld Schmiegelow, Peter M. Hoogerbrugge, Monique L. den Boer, Roland P. Kuiper, Anthony V. Moorman, Judith M. Boer, Frank N. van Leeuwen
Publikováno v:
HemaSphere, Vol 7, Iss 5, p e875 (2023)
IKZF1 deletions are an established prognostic factor in childhood acute lymphoblastic leukemia (ALL). However, their relevance in patients with good risk genetics, namely ETV6::RUNX1 and high hyperdiploid (HeH), ALL remains unclear. We assessed the p
Externí odkaz:
https://doaj.org/article/5645c5c18f97430d84ab7aaaba94a6bf
Autor:
Miriam Butler, Britt M.T. Vervoort, Dorette S. van Ingen Schenau, Lieneke Jongeneel, Jordy C.G. van der Zwet, René Marke, Jules P.P. Meijerink, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment. We previously reported that leukemias harboring deletions or muta
Externí odkaz:
https://doaj.org/article/bd62010cd4ac4cb38d96197bfa9e66ae
Autor:
Katharina Woess, Sabine Macho-Maschler, Dorette S. van Ingen Schenau, Miriam Butler, Caroline Lassnig, Daniel Valcanover, Andrea Poelzl, Katrin Meissl, Barbara Maurer, Tania Brandstoetter, Claus Vogl, Anna Koren, Stefan Kubicek, Anna Orlova, Richard Moriggl, Birgit Strobl, Veronika Sexl, Frank N. van Leeuwen, Roland P. Kuiper, Mathias Mueller
Publikováno v:
Haematologica, Vol 108, Iss 4 (2022)
Tyrosine kinase 2 (TYK2) is a member of the Janus kinase/signal transducer and activator of transcription pathway, which is central in cytokine signaling. Previously, germline TYK2 mutations have been described in two patients developing de novo T-ce
Externí odkaz:
https://doaj.org/article/16495fc0f1644407926d2399569c73ec
Autor:
Željko Antić, Jiangyan Yu, Simon V. van Reijmersdal, Anke van Dijk, Linde Dekker, Wouter H. Segerink, Edwin Sonneveld, Marta Fiocco, Rob Pieters, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Ad Geurts van Kessel, Esme Waanders, Roland P. Kuiper
Publikováno v:
Haematologica, Vol 106, Iss 12 (2020)
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity in initial diagnosis, with multiple (sub)clones harboring lesions in relapse-associated genes. However, the clinical relevance of these subclonal alte
Externí odkaz:
https://doaj.org/article/9dc8ce692dab4b10b6bd519bb4040df0
Autor:
Jiangyan Yu, Esmé Waanders, Simon V. van Reijmersdal, Željko Antić, Charlotte M. van Bosbeek, Edwin Sonneveld, Hester de Groot, Marta Fiocco, Ad Geurts van Kessel, Frank N. van Leeuwen, Rob Pieters, Peter M. Hoogerbrugge, Roland P. Kuiper
Publikováno v:
HemaSphere, Vol 4, Iss 1, p e318 (2020)
Abstract. Genomic alterations in relapsed B-cell precursor acute lymphoblastic leukemia (BCP-ALL) may provide insight into the role of specific genomic events in relapse development. Along this line, comparisons between the spectrum of alterations in
Externí odkaz:
https://doaj.org/article/9ea5833e05c3444d86e26bd16b66e6d5
Autor:
Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
Externí odkaz:
https://doaj.org/article/c62c2ded66004bc990ef9ad642a1059f
Autor:
Dunja M.W.M te Loo, Henk-Jan Guchelaar, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Uta Flucke, H.W. Bart Schreuder, Winette T.A. van der Graaf, Eveline S.J.M. de Bont, Hanneke I. Vos, Remco R. Makkinje, Hans Gelderblom, Marieke J.H. Coenen, Melanie M. Hagleitner
Supplementary Table 3. Genetic variants associated with 5-year PFS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373af66ca7e1657a72c7d47c2e65c4f8
https://doi.org/10.1158/1078-0432.22454916
https://doi.org/10.1158/1078-0432.22454916