Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Frank Mercurio"'
Autor:
Marcello Arsura, Snorri S. Thorgeirsson, Amer A. Beg, Frank Mercurio, Insa Schroeder, Swayamjot Kaur, Valentina M. Factor, Manickam Venkatraman, Lakita G. Cavin
Supplementary Figure Legends from Regulation of α-Fetoprotein by Nuclear Factor-κB Protects Hepatocytes from Tumor Necrosis Factor-α Cytotoxicity during Fetal Liver Development and Hepatic Oncogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593da30ce445ed11796c8fe3133b2ab6
https://doi.org/10.1158/0008-5472.22363817
https://doi.org/10.1158/0008-5472.22363817
Autor:
Marcello Arsura, Snorri S. Thorgeirsson, Amer A. Beg, Frank Mercurio, Insa Schroeder, Swayamjot Kaur, Valentina M. Factor, Manickam Venkatraman, Lakita G. Cavin
Nuclear factor-κB (NF-κB) plays a critical role during fetal liver development and hepatic oncogenesis. Here, we have assessed whether NF-κB activity is required for murine hepatocellular carcinoma cell survival. We show that adenoviral-mediated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f75d91e8a4b51f7b1231051f6fe62c4
https://doi.org/10.1158/0008-5472.c.6493910
https://doi.org/10.1158/0008-5472.c.6493910
Autor:
Marcello Arsura, Snorri S. Thorgeirsson, Amer A. Beg, Frank Mercurio, Insa Schroeder, Swayamjot Kaur, Valentina M. Factor, Manickam Venkatraman, Lakita G. Cavin
Supplementary Discussion from Regulation of α-Fetoprotein by Nuclear Factor-κB Protects Hepatocytes from Tumor Necrosis Factor-α Cytotoxicity during Fetal Liver Development and Hepatic Oncogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a458eff2d933a6812e8c1416ba09fe
https://doi.org/10.1158/0008-5472.22363820
https://doi.org/10.1158/0008-5472.22363820
Autor:
Leah Fung, Hans C. Lee, Richard J. Jones, Frank Mercurio, Robert W. Sullivan, Imelda Lam, David I. Stirling, Fazal Shirazi, Jianxuan Zou, Paul Erdman, David Hecht, Hua Wang, Normand Richard, Kyle W. H. Chan, Brooke McElwee, Aparajita Hoskote Chourasia, Elisabet E. Manasanch, Isere Kuiatse, Robert Z. Orlowski, Eduardo Torres
Publikováno v:
Journal of Molecular Medicine. 98:1161-1173
Small molecules targeting the cereblon-containing E3 ubiquitin ligase including thalidomide, lenalidomide, and pomalidomide modulate turnover of downstream client proteins and demonstrate pre-clinical and clinical anti-myeloma activity. Different dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06af628a339051f75823cfd26ea68ed
https://doi.org/10.1007/s00109-020-01943-6
https://doi.org/10.1007/s00109-020-01943-6
Autor:
Aparajita Hoskote Chourasia, Hannah Majeski, Angela Pasis, Paul Erdman, Ashwini Oke, David Hecht, David Lonergan, Frank Mercurio, Kyle Chan, Dung Luong Thai, Leah Fung
Publikováno v:
Journal of Clinical Oncology. 40:7025-7025
7025 Background: BTX-1188 is a first-in-class oral molecular glue that degrades GSPT1 and IKZF1/3 and is currently in phase 1 clinical trials for treatment of hematologic and solid malignancies. Targeted protein degradation of cereblon neosubstrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e1b6705c27eeba185d511f792b0eec0
https://doi.org/10.1200/jco.2022.40.16_suppl.7025
https://doi.org/10.1200/jco.2022.40.16_suppl.7025
Autor:
David Hecht, Kyle Chan, Paul Erdman, Eduardo Torres, yinon Ben-Neriah, Brooke McElwee, Frank Mercurio, Aparajita Chourasia, Leah Fung, Robert Sullivan, Imelda Calderon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbce36130955bb33ebe35f3bdfe327d
https://doi.org/10.1021/scimeetings.0c07400
https://doi.org/10.1021/scimeetings.0c07400
Autor:
Angela Pasis, Frank Mercurio, Chourasia Aparajita Hoskote, Paul Erdman, Kyle W. H. Chan, David I. Stirling, Sullivan Robert, Brooke McElwee, Normand Richard, Angela Schoolmeesters, Imelda Lam, David Hecht, Eduardo Torres, Leah Fung
Publikováno v:
Cancer Research. 80:1963-1963
BioTheryX's novel and unique Protein Homeostatic Modulators (PHMsTM) are small molecule “molecular glues” that promote ubiquitination of substrate proteins by the CRL4CRBN (CUL4-DDB1-RBX1-CRBN) ubiquitin ligase, leading to their subsequent degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b0878842e64e80c644e917c0c54718
https://doi.org/10.1158/1538-7445.am2020-1963
https://doi.org/10.1158/1538-7445.am2020-1963
Autor:
Guy Brachya, Yinon Ben-Neriah, Moshe Oren, Liran I. Shlush, Itay Omer, Amitai Rivlin, Robert W. Sullivan, Eli Pikarsky, Nathali Kaushansky, Li Dansu, Adar Zinger, Frank Mercurio, Ross L. Levine, Eitan Winter, Waleed Minzel, Ido Burstain, Avanthika Venkatachalam, Joseph Vacca, Leah Fung, Eric Hung, Maya Shaham, Irit Snir-Alkalay, Avner Fink, Paul Erdman, Shlomo Elias
Summary CKIα ablation induces p53 activation, and CKIα degradation underlies the therapeutic effect of lenalidomide in a pre-leukemia syndrome. Here we describe the development of CKIα inhibitors, which co-target the transcriptional kinases CDK7 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2440625cc9c49007ec76bcf64decbae
https://europepmc.org/articles/PMC6701634/
https://europepmc.org/articles/PMC6701634/
Autor:
David I. Stirling, Yinon Ben-Neriah, Imelda Lam, David Hecht, Irit Snir-Alkalay, Paul Erdman, Leah Fung, Kyle W. H. Chan, Frank Mercurio, Robert W. Sullivan, Eduardo Torres, Brooke McElwee, Aparajita Hoskote Chourasia, Normand Richard, Avanthika Venkatachalam
Publikováno v:
Blood. 134:4643-4643
BioTheryx's small-molecule kinase inhibitor, BTX-A51 (the ditosylated salt of A51), has recently received FDA approval of its IND application to initiate a Phase I clinical trial in relapsed or refractory acute myeloid leukemia (AML). A51 (API of BTX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7901d7e81d16150b5040f43fb830384b
https://doi.org/10.1182/blood-2019-131834
https://doi.org/10.1182/blood-2019-131834
Autor:
Robert W. Sullivan, Eduardo Torres, Paul Erdman, Leah Fung, David Hecht, Imelda Lam, Frank Mercurio, Brooke McElwee, Aparajita Hoskote Chourasia, David I. Stirling, Normand Richard, Kyle W. H. Chan
Publikováno v:
Blood. 134:3361-3361
Targeting disease-relevant proteins by exploiting the cells' very own protein homeostasis machinery is the next generation drug discovery platform that has come center stage for treatment of hematological malignancies. We present our novel and unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47590684ddbee080a7c800653f35ab3
https://doi.org/10.1182/blood-2019-131872
https://doi.org/10.1182/blood-2019-131872