Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Frank McCarthy"'
Autor:
Kun Leng, Brendan Rooney, Frank McCarthy, Wenlong Xia, Indigo V. L. Rose, Sophie Bax, Marcus Chin, Saeed Fathi, Kari A. Herrington, Manuel Leonetti, Aimee Kao, Stephen P. J. Fancy, Joshua E. Elias, Martin Kampmann
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inf
Externí odkaz:
https://doaj.org/article/3362c7cd0c774b99bc1e41cc97a52ae6
Autor:
Jessica Burns, Christopher P. Wilding, Lukas Krasny, Xixuan Zhu, Madhumeeta Chadha, Yuen Bun Tam, Hari PS, Aswanth H. Mahalingam, Alexander T. J. Lee, Amani Arthur, Nafia Guljar, Emma Perkins, Valeriya Pankova, Andrew Jenks, Vanessa Djabatey, Cornelia Szecsei, Frank McCarthy, Chanthirika Ragulan, Martina Milighetti, Theodoros I. Roumeliotis, Stephen Crosier, Martina Finetti, Jyoti S. Choudhary, Ian Judson, Cyril Fisher, Eugene F. Schuster, Anguraj Sadanandam, Tom W. Chen, Daniel Williamson, Khin Thway, Robin L. Jones, Maggie C. U. Cheang, Paul H. Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of tumour specimens from 321 STS patients representing 11 histological subtypes. Within l
Externí odkaz:
https://doaj.org/article/9d213184d1a64b60a226a35cf5a6990a
Autor:
Evgeny Zatulovskiy, Michael C. Lanz, Shuyuan Zhang, Frank McCarthy, Joshua E. Elias, Jan M. Skotheim
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Increasing cell size drives changes to the proteome, which affects cell physiology. As cell size increases, some proteins become more concentrated while others are diluted. As a result, the state of the cell changes continuously with increasing size.
Externí odkaz:
https://doaj.org/article/1e1f1d973fe44e06a78a98a00e83a3e0
Autor:
Jocelyn P. Wong, Jason R. Todd, Martina A. Finetti, Frank McCarthy, Malgorzata Broncel, Simon Vyse, Maciej T. Luczynski, Stephen Crosier, Karen A. Ryall, Kate Holmes, Leo S. Payne, Frances Daley, Patty Wai, Andrew Jenks, Barbara Tanos, Aik-Choon Tan, Rachael C. Natrajan, Daniel Williamson, Paul H. Huang
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1265-1275 (2016)
Summary: Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here,
Externí odkaz:
https://doaj.org/article/1ea3b596e8cc4e36bc647eff1eeb7332
Autor:
Justine Maller, Terry Morgan, Mayu Morita, Frank McCarthy, Yunshin Jung, Katrin J Svensson, Joshua E Elias, Claudia Macaubas, Elizabeth Mellins
Publikováno v:
Journal of Leukocyte Biology.
Objectives Systemic juvenile idiopathic arthritis (sJIA) is a chronic pediatric inflammatory disease of unknown etiology, characterized by fever, rash, hepatosplenomegaly, serositis and arthritis. We hypothesized that intercellular communication, med
Autor:
Christina Cipriano, Michael J. Strambler, Lauren Naples, Cheyeon Ha, Megan A. Kirk, Miranda Elizabeth Wood, Kaveri Sehgal, Almut Klara Zieher, Abigail Eveleigh, Michael Frank McCarthy, Melissa C Funaro, Annette Ponnock, Jason Chow, Joseph Durlak
This article provides a systematic review and meta-analysis of the current evidence for universal school-based (USB) social and emotional learning (SEL) interventions for students in kindergarten through 12th grade available from 2008 through 2020. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2828ff69a0fe45d5c69350080dac11a4
https://doi.org/10.31219/osf.io/mk35u
https://doi.org/10.31219/osf.io/mk35u
Autor:
Caleigh Mandel‐Brehm, Leslie A. Benson, Baouyen Tran, Andrew F. Kung, Sabrina A. Mann, Sara E. Vazquez, Hanna Retallack, Hannah A. Sample, Kelsey C. Zorn, Lillian M. Khan, Lauren M. Kerr, Patrick L. McAlpine, Lichao Zhang, Frank McCarthy, Joshua E. Elias, Umakanth Katwa, Christina M. Astley, Stuart Tomko, Josep Dalmau, William W. Seeley, Samuel J. Pleasure, Michael R. Wilson, Mark P. Gorman, Joseph L. DeRisi
Publikováno v:
Annals of neurology, vol 92, iss 2
ObjectiveRapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic Dysregulation (ROHHAD), is a severe pediatric disorder of uncertain etiology resulting in hypothalamic dysfunction and frequent sudden death. Frequent co-occurr
Autor:
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y. S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loïc A. Royer, Matthias Mann, Manuel D. Leonetti
Publikováno v:
Science
Cho, N H, Cheveralls, K C, Brunner, A D, Kim, K, Michaelis, A C, Raghavan, P, Kobayashi, H, Savy, L, Li, J Y, Canaj, H, Kim, J Y S, Stewart, E M, Gnann, C, McCarthy, F, Cabrera, J P, Brunetti, R M, Chhun, B B, Dingle, G, Hein, M Y, Huang, B, Mehta, S B, Weissman, J S, Gómez-Sjöberg, R, Itzhak, D N, Royer, L A, Mann, M & Leonetti, M D 2022, ' OpenCell : Endogenous tagging for the cartography of human cellular organization ', Science, vol. 375, no. 6585, eabi6983 . https://doi.org/10.1126/science.abi6983
Cho, N H, Cheveralls, K C, Brunner, A D, Kim, K, Michaelis, A C, Raghavan, P, Kobayashi, H, Savy, L, Li, J Y, Canaj, H, Kim, J Y S, Stewart, E M, Gnann, C, McCarthy, F, Cabrera, J P, Brunetti, R M, Chhun, B B, Dingle, G, Hein, M Y, Huang, B, Mehta, S B, Weissman, J S, Gómez-Sjöberg, R, Itzhak, D N, Royer, L A, Mann, M & Leonetti, M D 2022, ' OpenCell : Endogenous tagging for the cartography of human cellular organization ', Science, vol. 375, no. 6585, eabi6983 . https://doi.org/10.1126/science.abi6983
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a049f7d9c40a5608e3af31026808cb
https://hdl.handle.net/21.11116/0000-000A-3C9B-521.11116/0000-000A-3C9D-3
https://hdl.handle.net/21.11116/0000-000A-3C9B-521.11116/0000-000A-3C9D-3
Autor:
Manuel D. Leonetti, Saeed Fathi, Aimee W. Kao, Kari A. Herrington, Sophie Bax, Martin Kampmann, Kun Leng, Marcus Y. Chin, Joshua E. Elias, Frank McCarthy, Indigo V.L. Rose, Brendan Rooney
Inflammatory reactive astrocytes lose homeostatic functions and can be neurotoxic, potentially contributing to neurodegenerative diseases. However, the underlying cell biological mechanisms are not fully understood. Here, we demonstrate that lysosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf62582038ac0c543128bc3b8140882f
https://doi.org/10.1101/2021.09.11.459904
https://doi.org/10.1101/2021.09.11.459904
Autor:
Jürgen Cox, Favio Salinas Soto, Sean J. Humphrey, Frank McCarthy, Hamid Hamzeiy, Şule Yılmaz, Stefan Tenzer, Daniel N. Itzhak, Christoph Wichmann, Yasset Perez-Riverol, Martin Steger, Nikita Prianichnikov, Uli Ohmayer, Stephanie Kaspar-Schoenefeld, Pavel Sinitcyn, Nagarjuna Nagaraj, Jan Daniel Rudolph, Ute Distler
Publikováno v:
Nature Biotechnology
MaxDIA is a software platform for analyzing data-independent acquisition (DIA) proteomics data within the MaxQuant software environment. Using spectral libraries, MaxDIA achieves deep proteome coverage with substantially better coefficients of variat