Výsledky vyhledávání - "Frank M.H. Lee"

Autor: Edward L.G. Pryzdial, Tseday Z. Tegegn, Bryan H. Lin, Mark Belletrutti, Rolinda L.R. Carter, Frank M.H. Lee

Publikováno v: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 57(4)

Hemostasis is the physiological control of bleeding and is initiated by subendothelial exposure. Platelets form the primary vascular seal in three stages (localization, stimulation and aggregation), which are triggered by specific interactions betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f398f53a38bbdd861283dad3c51cfe72
https://pubmed.ncbi.nlm.nih.gov/30049564

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Thrombolysis by chemically modified coagulation factor Xa

Autor: James R. Baylis, Louise J. Eltringham-Smith, William P. Sheffield, Edward L.G. Pryzdial, Scott C. Meixner, Kimberley Talbot, Frank M.H. Lee, Christian J. Kastrup

Publikováno v: Journal of thrombosis and haemostasis : JTH. 14(9)

Essentials Factor Xa (FXa) acquires cleavage-mediated tissue plasminogen activator (tPA) cofactor activity. Recombinant (r) tPA is the predominant thrombolytic drug, but it may cause systemic side effects. Chemically modified, non-enzymatic FXa was p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc359322bfd012085054f2c9cf7af47
https://pubmed.ncbi.nlm.nih.gov/27359348

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Reversal of new, factor-specific oral anticoagulants by rFVIIa, prothrombin complex concentrate and activated prothrombin complex concentrate: a review of animal and human studies

Autor: Keith K. Lau, Anthony K.C. Chan, Howard H.W. Chan, Frank M.H. Lee

Publikováno v: Thrombosis research. 133(5)

Introduction Recombinant activated factor VII (rFVIIa), prothrombin complex concentrate (PCC) and activated PCC (aPCC) are three non-specific haemostatic agents sometimes employed to reverse new, factor-specific oral anticoagulants. Methods We conduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5319d2ddeb845f442ae9c95ff49ae31c
https://pubmed.ncbi.nlm.nih.gov/24666649

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Reversal Of Dabigatran By Recombinant Factor VIIa Is Dependent On The Amount Of Tissue-Factor

Autor: Howard H.W. Chan, Keith K. Lau, Anthony K.C. Chan, Ivan Stevic, Xena X Li, Frank M.H. Lee

Publikováno v: Blood. 122:1149-1149

Background Dabigatran is a new oral anticoagulant that specifically and reversibly inhibits thrombin. Its predictable pharmacokinetics and pharmacodynamics allow for minimal monitoring. However, there is currently no specific antidote to reverse its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f22759d34ca0cd9ded61447f074f66a0
https://doi.org/10.1182/blood.v122.21.1149.1149

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