Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Frank M. Orson"'
Autor:
Colin N. Haile, Kurt J. Varner, Xia Huijing, Reetakshi Arora, Frank M. Orson, Thomas R. Kosten, Therese A. Kosten
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1508 (2022)
Background: Methamphetamine use disorder (MUD) is a growing health concern with no FDA-approved treatment. The present series of studies build upon our previous work developing an anti-methamphetamine (MA) vaccine for MUD. We determined the effects o
Externí odkaz:
https://doaj.org/article/b78660c9227a43e9b51847c33f5f5a46
Autor:
Yan Wu, Frank M. Orson, Lynn D. Hawkins, Colin N. Haile, Reetakshi Arora, Thomas R. Kosten, Therese A. Kosten, Muthu Ramakrishnan
Publikováno v:
The American Journal on Addictions. 28:119-126
BACKGROUND AND OBJECTIVE Methamphetamine (MA) substance use disorder (SUD) does not have an efficacious pharmacotherapy. We developed a MA vaccine and investigated its potential to attenuate MA induced responses. METHODS We examined a novel adjuvant,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ffba3f111f6fe62efb4443df07491c7
https://doi.org/10.1111/ajad.12867
https://doi.org/10.1111/ajad.12867
Autor:
Marilyn E Carroll, Natalie E Zlebnik, Justin J Anker, Thomas R Kosten, Frank M Orson, Xiaoyun Shen, Berma Kinsey, Robin J Parks, Yang Gao, Stephen Brimijoin
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43536 (2012)
Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of
Externí odkaz:
https://doaj.org/article/3f9b485801a24cc18b5905678ff7ad7a
Autor:
Muthu Ramakrishnan, Fernando Alves De Melo, Berma M Kinsey, John E Ladbury, Thomas R Kosten, Frank M Orson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40518 (2012)
Despite progress in cocaine immunotherapy, the kinetic and thermodynamic properties of antibodies which bind to cocaine and its metabolites are not well understood. It is also not clear how the interactions between them differ in a complex matrix suc
Externí odkaz:
https://doaj.org/article/6380eac9b7fb4218b97709fa761f598e
Autor:
Yan Wu, Ernest D. Lykissa, Zhen Huang, Patrick W. O'Malley, Frank M. Orson, Therese A. Kosten, Kevin J. Winoske, Reetakshi Arora, Berma M. Kinsey, Thomas R. Kosten, Naga Naidu, Joseph A. Cox, Xiaoyun Y. Shen, Colin N. Haile
Publikováno v:
The American Journal on Addictions. 24:748-755
Background and Objectives We previously reported that an anti-methamphetamine (MA) vaccine attenuated drug-conditioned effects in mice, but it used a carrier protein and adjuvant not available for clinical use. Here we produced a vaccine with the sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e13378866317bad8f16fc0af5c7d8e6
https://doi.org/10.1111/ajad.12307
https://doi.org/10.1111/ajad.12307
Publikováno v:
The American Journal on Addictions. 23:604-607
Background and Objectives Immunotherapy for drug addiction is being investigated in several laboratories but most studies are conducted in animals of one sex. Yet, women show heightened immune responses and are more likely to develop autoimmune disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab2a385525af0105a84434f24560353
https://doi.org/10.1111/j.1521-0391.2014.12152.x
https://doi.org/10.1111/j.1521-0391.2014.12152.x
Autor:
Rana A. K. Singh, Stephen Brimijoin, Rongfu Wang, Thomas R. Kosten, Helen Yicheng Wang, Berma M. Kinsey, Frank M. Orson, Muthu Ramakrishnan
Publikováno v:
Expert Opinion on Biological Therapy. 14:1271-1283
Addiction to cocaine is a major problem around the world, but especially in developed countries where the combination of wealth and user demand has created terrible social problems. Although only some users become truly addicted, those who are often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a9eee4968176774bbf1eec21dbc42d
https://doi.org/10.1517/14712598.2014.920319
https://doi.org/10.1517/14712598.2014.920319
Publikováno v:
British Journal of Clinical Pharmacology. 77:368-374
While the worldwide prevalence of cocaine use remains significant, medications, or small molecule approaches, to treat drug addictions have met with limited success. Anti-addiction vaccines, on the other hand, have demonstrated great potential for tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1436bd70fd32f1294f1c30599ced3199
https://doi.org/10.1111/bcp.12115
https://doi.org/10.1111/bcp.12115
Autor:
Xiaoyun Y. Shen, Therese A. Kosten, Thomas R. Kosten, Berma M. Kinsey, Frank M. Orson, Angel Y. Lopez
Publikováno v:
Drug and Alcohol Dependence. 129:41-48
Background Vaccines have treatment potential for methamphetamine (MA) addiction. We tested whether a conjugate vaccine against MA (succinyl-methamphetamine-keyhole limpet hemocyanin carrier protein; SMA-KLH) would generate MA antibodies and alter MA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66a99799d12d3284f99d1330ac7308a
https://doi.org/10.1016/j.drugalcdep.2012.09.007
https://doi.org/10.1016/j.drugalcdep.2012.09.007
Autor:
Yang Gao, Liyi Geng, Xiaoyun Shen, Berma M. Kinsey, Thomas R. Kosten, Stephen Brimijoin, Frank M. Orson
Publikováno v:
Chemico-Biological Interactions. 203:208-211
In developing an vivo drug-interception therapy to treat cocaine abuse and hinder relapse into drug seeking provoked by re-encounter with cocaine, two promising agents are: (1) a cocaine hydrolase enzyme (CocH) derived from human butyrylcholinesteras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e8e8c379c07ef3a295c63c57948ab1
https://doi.org/10.1016/j.cbi.2012.08.006
https://doi.org/10.1016/j.cbi.2012.08.006