Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Frank M. Nedza"'
Autor:
Jason Boer, William Frietze, Andrew P. Combs, Jack G. Shi, Frank M Nedza, Ruth Young-Sciame, Swamy Yeleswaram, Sharon Diamond, Fiona Lee, Kevin Bowman, Laurine G. Galya, Xiaoqing Yang
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(10)
Epacadostat (EPA, INCB024360) is a first-in-class, orally active, investigational drug targeting the enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In Phase I studies, EPA has demonstrated promising clinical activity when used in combination with check
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e17ee2a8873cce1fba23b5b5fb5871
https://pubmed.ncbi.nlm.nih.gov/27457784
https://pubmed.ncbi.nlm.nih.gov/27457784
Autor:
Rama Y. Chandrasekaran, Jiri Aubrecht, Frederick R. Nelson, Linda A. Chatman, Hans Rollema, Frank M. Nedza, John M. Marcek, Philip A. Iredale, Jennifer B. Munzner, Betty Pettersen, Raggon Jeffrey W, David M. Rubitski, Julie Cianfrogna, Larry C. James, Karen W. Cook, Michael J. Banker, Diane F. Wong, Anne W. Schmidt, Michael Homiski, Howard Harry R, Daniel J. Lettiere, Butler Todd W, Scot Richard Mente, Jody Freeman, Travis T. Wager, Douglas K. Spracklin
Publikováno v:
Journal of Medicinal Chemistry. 54:7602-7620
The discovery of two histamine H3 antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success in iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c253ef2a0b55c8bf1f6522eccc0c6ed
https://doi.org/10.1021/jm200939b
https://doi.org/10.1021/jm200939b
Autor:
Matthew W. Miller, F. Fátima Matos, Frank M. Nedza, Yvette E. Savoy, Hans Rollema, Douglas K. Spracklin, Mark H. Hawthorn, Eva Hajos-Korcsok, Michael A. Ashton
Publikováno v:
Schizophrenia Bulletin. 36:410-418
Atypical antipsychotic treatment has been associated with serious metabolic adverse events, such as glucose dysregulation and development of type 2 diabetes. As part of our studies on possible underlying mechanisms, we investigated the acute effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ac8185b8f57b6972b52ce6aff9c269
https://doi.org/10.1093/schbul/sbn104
https://doi.org/10.1093/schbul/sbn104
Autor:
Hans Rollema, Philip A. Iredale, Karen M. Ward, Anne W. Schmidt, Frank M. Nedza, Godek Dennis M, David E. Johnson, Douglas K. Spracklin
Publikováno v:
European Journal of Pharmacology. 506:209-219
Olanzapine and clozapine produce robust increases in hippocampal acetylcholine release during acetylcholinesterase inhibition, while other antipsychotics, including thioridazine, have only small effects. Since thioridazine binds with similar high aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a8ac5f76b8a6632fea17a1d3d7a907
https://doi.org/10.1016/j.ejphar.2004.11.015
https://doi.org/10.1016/j.ejphar.2004.11.015
Autor:
Travis T, Wager, Betty A, Pettersen, Anne W, Schmidt, Douglas K, Spracklin, Scot, Mente, Todd W, Butler, Harry, Howard, Daniel J, Lettiere, David M, Rubitski, Diane F, Wong, Frank M, Nedza, Frederick R, Nelson, Hans, Rollema, Jeffrey W, Raggon, Jiri, Aubrecht, Jody K, Freeman, John M, Marcek, Julie, Cianfrogna, Karen W, Cook, Larry C, James, Linda A, Chatman, Philip A, Iredale, Michael J, Banker, Michael L, Homiski, Jennifer B, Munzner, Rama Y, Chandrasekaran
Publikováno v:
Journal of medicinal chemistry. 54(21)
The discovery of two histamine H(3) antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success in id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2437f9ba9156d813302f64ee16a8582b
https://pubmed.ncbi.nlm.nih.gov/21928839
https://pubmed.ncbi.nlm.nih.gov/21928839
Autor:
William V. Williams, Adam Shilling, Argyrios G. Arvanitis, Sharon Diamond, James D. Rodgers, Laurine G. Galya, Tai-Yuen Yue, Thomas Emm, Swamy Yeleswaram, Edward G. McKeever, Stacey Shepard, Mei Li, Frank M. Nedza, Naresh Punwani
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 38(11)
The metabolism, excretion, and pharmacokinetics of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile (INCB018424), a potent, selective inhibitor of Janus tyrosine kinase1/2 and the first investigational drug of its c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52d1a57fc34e814839d71a024ca5518
https://pubmed.ncbi.nlm.nih.gov/20699411
https://pubmed.ncbi.nlm.nih.gov/20699411
Autor:
Alka Shrikhande, Eric P. Arnold, Lorraine A. Lebel, Langu Peng, Frank M. Nedza, Brian T. O’Neill, Douglas K. Spracklin, Robert J. Mather, Steven B. Sands, Christopher J. O’Donnell
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
The synthesis and SAR studies about the bicyclic amine, carbamate linker and aromatic ring of a 1,4-diazabicyclo[3.2.2]nonane phenyl carbamate series of alpha7 nAChR agonists is described. The development of the medicinal chemistry strategy and SAR w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810702d35a2b08f6f102ead87be5cd61
https://pubmed.ncbi.nlm.nih.gov/19576766
https://pubmed.ncbi.nlm.nih.gov/19576766
Autor:
Douglas K. Spracklin, Frederick R. Nelson, Jennifer L. LaPerle, R. Scott Obach, Karthik Venkatakrishnan, Adam Yasgar, Ellen Q. Wang, Cuiping Chen, Sandhya Rahematpura, John P. Gibbs, Emily R. Olson, Kari Schmidt, Michael J. Logman, Ernesto Callegari, Cornelis E. C. A. Hop, Gary Walens, Xi Chen, Mark A. Szewc, Elaine E. Tseng, Frank M. Nedza, Heather L. Hatch, Meihua Tu, Matthew D. Troutman, Stacey L. Becker, Sabrinia Rogers, Megan A. Gibbs, Debra Maclin, Xingrong Liu, Ilana N. Kasman, Natilie Hosea, Diane Wong, Bill J. Smith, Loretta M. Cox, Jeffrey Van Deusen, Julie Cianfrogna, JianHua Liu, Edna F. Choo, Angela C. Doran, David Raunig, Chenghong Zhang
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 33(1)
Thirty-two structurally diverse drugs used for the treatment of various conditions of the central nervous system (CNS), along with two active metabolites, and eight non-CNS drugs were measured in brain, plasma, and cerebrospinal fluid in the P-glycop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aab549d8a51545ac8338523bb0e8f93
https://pubmed.ncbi.nlm.nih.gov/15502009
https://pubmed.ncbi.nlm.nih.gov/15502009
Autor:
Travis T. Wager, Betty A. Pettersen, Anne W. Schmidt, Douglas K. Spracklin, Scot Mente, Todd W. Butler, Harry Howard, Daniel J. Lettiere, David M. Rubitski, Diane F. Wong, Frank M. Nedza, Frederick R. Nelson, Hans Rollema, Jeffrey W. Raggon, Jiri Aubrecht, Jody K. Freeman, John M. Marcek, Julie Cianfrogna, Karen W. Cook, Larry C. James
Publikováno v:
Journal of Medicinal Chemistry; Nov2011, Vol. 54 Issue 21, p7602-7620, 19p