Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Frank M. LaFerla"'
Autor:
Tee Jong Huat, Judith Camats-Perna, Estella A. Newcombe, Tessa Onraet, Daniel Campbell, Josiah T. Sucic, Alessandra Martini, Stefânia Forner, Mehdi Mirzaei, Wayne Poon, Frank M. LaFerla, Rodrigo Medeiros
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Astrocytes play a role in healthy cognitive function and Alzheimer’s disease (AD). The transcriptional factor nuclear factor-κB (NF-κB) drives astrocyte diversity, but the mechanisms are not fully understood. By combining studies in huma
Externí odkaz:
https://doaj.org/article/d45850a975f546e0b5129c724d247f07
Autor:
Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined th
Externí odkaz:
https://doaj.org/article/c8e7a6b3cbd440008791292cdd23c305
Autor:
Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A. Castello, Andranik A. Agazaryan, Joy L. Davis, Franz-Josef Müller, Jeanne F. Loring, Eliezer Masliah, Frank M. LaFerla
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/a8f7f613f4364215aed3a6cbb63b15c4
Autor:
Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine S. Sakr, Angela Gomez-Arboledas, Miguel A. Arreola, Celia da Cunha, Jimmy Phan, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Jonathan Neumann, Ghassan Filimban, Zechuan Shi, Giedre Milinkeviciute, Dominic I. Javonillo, Katelynn Tran, Magdalena Gantuz, Stefania Forner, Vivek Swarup, Andrea J. Tenner, Frank M. LaFerla, Marcelo A. Wood, Ali Mortazavi, Grant R. MacGregor, Kim N. Green
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-26 (2023)
Abstract Background The TREM2 R47H variant is one of the strongest genetic risk factors for late-onset Alzheimer’s Disease (AD). Unfortunately, many current Trem2 R47H mouse models are associated with cryptic mRNA splicing of the mutant allele that
Externí odkaz:
https://doaj.org/article/7cc752a4e65d4dbe841fd116a51289c8
Autor:
Stefania Forner, Shimako Kawauchi, Gabriela Balderrama-Gutierrez, Enikö A. Kramár, Dina P. Matheos, Jimmy Phan, Dominic I. Javonillo, Kristine M. Tran, Edna Hingco, Celia da Cunha, Narges Rezaie, Joshua A. Alcantara, David Baglietto-Vargas, Camden Jansen, Jonathan Neumann, Marcelo A. Wood, Grant R. MacGregor, Ali Mortazavi, Andrea J. Tenner, Frank M. LaFerla, Kim N. Green
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-16 (2021)
Measurement(s) Protein Expression • gene expression • electrophysiology data • protein measurement • behavior Technology Type(s) immunofluorescence microscopy assay • RNA sequencing • electrophysiology assay • Electrochemiluminescence I
Externí odkaz:
https://doaj.org/article/b2396bfe67d3413cbec4c74a4d952aef
Autor:
David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelli
Externí odkaz:
https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf
Autor:
Sugako Oka, Julio Leon, Kunihiko Sakumi, Nona Abolhassani, Zijing Sheng, Daisuke Tsuchimoto, Frank M. LaFerla, Yusaku Nakabeppu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract 8-Oxoguanine (8-oxoG), a major oxidative base lesion, is highly accumulated in Alzheimer’s disease (AD) brains during the pathogenic process. MTH1 hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, thereby avoiding 8-oxo-dG incorporation into DNA. 8-Oxo
Externí odkaz:
https://doaj.org/article/2da47d76ddfd4f32a7a7bc3c676d5685
Autor:
Heather M. Terron, Derek S. Maranan, Luke A. Burgard, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6745 (2023)
Commonly employed methods for reversibly disrupting gene expression, such as those based on RNAi or CRISPRi, are rarely capable of achieving >80–90% downregulation, making them unsuitable for targeting genes that require more complete disruption to
Externí odkaz:
https://doaj.org/article/0d0397e39d2b49f09eb1370c0a6f6828
Autor:
Xiaoxiao Lin, Lujia Chen, David Baglietto-Vargas, Parsa Kamalipour, Qiao Ye, Frank M. LaFerla, Douglas A. Nitz, Todd C. Holmes, Xiangmin Xu
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105562- (2022)
Alzheimer's disease (AD) causes progressive age-related defects in memory and cognitive function and has emerged as a major health and socio-economic concern in the US and worldwide. To develop effective therapeutic treatments for AD, we need to bett
Externí odkaz:
https://doaj.org/article/f667be4f8aaf42f4b2c182b542f8b9f2
Autor:
Dominic I. Javonillo, Kristine M. Tran, Jimmy Phan, Edna Hingco, Enikö A. Kramár, Celia da Cunha, Stefania Forner, Shimako Kawauchi, Giedre Milinkeviciute, Angela Gomez-Arboledas, Jonathan Neumann, Crystal E. Banh, Michelle Huynh, Dina P. Matheos, Narges Rezaie, Joshua A. Alcantara, Ali Mortazavi, Marcelo A. Wood, Andrea J. Tenner, Grant R. MacGregor, Kim N. Green, Frank M. LaFerla
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Animal models of disease are valuable resources for investigating pathogenic mechanisms and potential therapeutic interventions. However, for complex disorders such as Alzheimer’s disease (AD), the generation and availability of innumerous distinct
Externí odkaz:
https://doaj.org/article/677dc4105eff49cab8550eb3df2b59bd