Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Frank M. Köhn"'
Autor:
Artur Mayerhofer, Lars Kunz, Manja Luckner, Gerhard Wanner, Florian Flenkenthaler, Georg J. Arnold, Frank M. Köhn, Jan B. Stöckl, Nina Schmid, Thomas Fröhlich, Kim-Gwendolyn Dietrich, J. Ullrich Schwarzer
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
There is evidence for an age-related decline in male reproductive functions, yet how the human testis may age is not understood. Human testicular peritubular cells (HTPCs) transport sperm, contribute to the spermatogonial stem cell (SSC) niche and im
Autor:
Rüdiger Behr, Nina Schmid, Henryk F. Urbanski, Matti Poutanen, Frank M. Köhn, Leena Strauss, J. Ullrich Schwarzer, Artur Mayerhofer, Lena Walenta
Publikováno v:
Reproduction. 156:231-238
NLRP3 is part of the NLRP3 inflammasome and a global sensor of cellular damage. It was recently discovered in rodent Sertoli cells. We investigated NLRP3 in mouse, human and non-human primate (marmoset and rhesus macaque) testes, employing immunohist
Autor:
Heiko Steinfatt, I. von Hertwig, Frank M. Köhn, G. Krüsmann, J. U. Schwarzer, W. Würfel, M. Schleyer, Klaus Fiedler
Publikováno v:
Andrologia. 48:402-405
Nonobstructive azoospermia is caused in up to 10% by microdeletions of the Y chromosome in the azoospermia factor (AZF) region, which is divided into three nonoverlapping areas (AZFa, AZFb and AZFc). In 25 male patients with AZF microdeletions, the r
Autor:
Ulrich Welsch, Artur Mayerhofer, Matti Poutanen, Henryk F. Urbanski, J. Ullrich Schwarzer, Vasilios T. Garyfallou, Frank M. Köhn, Leena Strauss, Marion Adam
Publikováno v:
International Journal of Andrology. 35:550-561
Decorin (DCN), a component of the extracellular matrix of the peritubular wall and the interstitial areas of the human testis, can interact with growth factor (GF) signaling, thereby blocking downstream actions of GFs. In the present study the expres
Autor:
Harald Dörr, Horst Zitzelsberger, Oliver Das, Theodor M. Fliedner, Frank M. Köhn, Hans Pillekamp, Kerstin Müller, Herbert Braselmann, Harry Scherthan, Viktor Meineke, Christina Beinke, R. Schiener, Ralf U. Peter, Michael Abend, Andreas Tzschach, Gerhard Herzog
Publikováno v:
Radiat. Res. 167, 615-623 (2007)
Radiation exposure leads to a risk for long-term deterministic and stochastic late effects. Two individuals exposed to protracted photon radiation in the radiological accident at the Lilo Military site in Georgia in 1997 received follow-up treatment
Publikováno v:
Proceedings of the National Academy of Sciences. 99:15072-15077
Mast-cell products can stimulate fibroblast proliferation, implying that these cells are key players in fibrosis. One mast-cell product, the serine protease tryptase, is known to activate protease-activated receptor 2 (PAR2) and cause proliferation o
Autor:
Frank M. Köhn, Ricardo S. Calandra, Viktor Meineke, Hermann Josef Vogt, Livia Lustig, Monica Beatriz Frungieri, Artur Mayerhofer
Publikováno v:
Fertility and Sterility. 78:298-306
Objective: To investigate the number, location, and secretory products of macrophages in human testes showing normal and abnormal spermatogenesis. Design: Evaluation of testicular biopsies with the use of immunohistochemistry, laser capture microdiss
Autor:
M. Schleyer, G. Krüsmann, Irene von Hertwig, W. Würfel, Heiko Steinfatt, Frank M. Köhn, J. Ullrich Schwarzer, Klaus Fiedler
Publikováno v:
Asian journal of andrology. 15(6)
In 220 consecutive patients with non-obstructive azoospermia, sperm retrieval was attempted by a combination of conventional and microdissection testicular sperm extraction (TESE). For sperm retrieval, 2-3 conventional biopsies were performed followe
Publikováno v:
Fertility and sterility. 96(2)
Objective To determine intratesticular abundance and distribution of tryptase-positive mast cells (MCs) and to examine the expression of key enzymes of prostaglandin (PG) synthesis, cyclooxygenase 2 (COX2), and PGD2 synthase in the testes of men with
Publikováno v:
Asian journal of andrology. 9(5)
Aim: To investigate mechanisms of tryptase-induced reduction of sperm motility and explore whether epidermal growth factor receptor (EGF-R) and protease activated receptor 2 (PAR-2)- associated pathways are involved. Methods: Fresh semen was collecte