Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Frank M. Dautzenberg"'
Autor:
G. Karina Parra-Mercado, Alma M. Fuentes-Gonzalez, Judith Hernandez-Aranda, Monica Diaz-Coranguez, Frank M. Dautzenberg, Kevin J. Catt, Richard L. Hauger, J. Alberto Olivares-Reyes
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
In the present study, we determined the cellular regulators of ERK1/2 and Akt signaling pathways in response to human CRF1 receptor (CRF1R) activation in transfected COS-7 cells. We found that Pertussis Toxin (PTX) treatment or sequestering Gβγ red
Externí odkaz:
https://doaj.org/article/0f469014d60e48bdb342ec1765ed2af7
Autor:
J. Alberto Olivares-Reyes, Frank M. Dautzenberg, Monica Diaz-Coranguez, Judith Hernandez-Aranda, Richard L. Hauger, Alma M. Fuentes-Gonzalez, Kevin J. Catt, G. Karina Parra-Mercado
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Frontiers in Endocrinology
Frontiers in Endocrinology
In the present study, we determined the cellular regulators of ERK1/2 and Akt signaling pathways in response to human CRF1 receptor (CRF1R) activation in transfected COS-7 cells. We found that Pertussis Toxin (PTX) treatment or sequestering Gβγ red
Autor:
Wylie W. Vale, Frank M. Dautzenberg, Dimitri E. Grigoriadis, Victoria B. Risbrough, Thomas Steckler, Richard L. Hauger, Rita J. Valentino
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Corticotropin-releasing factor (CRF, nomenclature as agreed by the NC-IUPHAR subcommittee on Corticotropin-releasing Factor Receptors [30]) receptors are activated by the endogenous peptides corticotrophin-releasing hormone, a 41 amino-acid peptide,
Autor:
Zaki Munshi, Dibyendu Mondal, Velavan Armugam, Frank M. Dautzenberg, Claude Ostermann, Amit Bhalerao, Vinod Gudaghe, Guido Hanauer, Nisha Pansare, Koushik Das Sarma, Mahendra Gupta, Klaus Mann, Pramila Rayudu, Michaela Schaefer, Sandra Nappe, Afsar Ali Siddiki, Cornelia Weiss-Haljiti, Christof Zitt, Hans-Peter Kley, Yithachu Thur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7314-7321
SAR studies were performed on a series of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists. Starting from a HTS hit both potency and selectivity could be improved. Modifications to the thiophene
Autor:
Richard L. Hauger, J. Alberto Olivares-Reyes, Sandra Braun, Robert H. Oakley, James B. Lohr, Frank M. Dautzenberg
Publikováno v:
Neuropharmacology. 62:705-714
The reasons for differences in vulnerability or resilience to the development of posttraumatic stress disorder (PTSD) are unclear. Here we review key genetic diatheses and molecular targets especially signaling pathways that mediate responses to trau
Autor:
Thomas Steckler, Hassan Julien Imogai, Wilhelmus Drinkenburg, Abdellah Ahnaou, Dieder Moechars, Frank M. Dautzenberg, Antoine Gibelin, Helena Geys
Publikováno v:
European Journal of Pharmacology. 603:62-72
Compiling pharmacological evidence implicates metabotropic glutamate mGlu 2 receptors in the regulation of emotional states and suggests positive modulators as a novel therapeutic approach of Anxiety/Depression and Schizophrenia. Here, we investigate
Autor:
Georges Vauquelin, Richard L. Hauger, Eric Gutknecht, Frank M. Dautzenberg, Ilse Van der Linden
Publikováno v:
Journal of Neurochemistry. 104:926-936
Endogenous expression of the corticotropin-releasing factor type 2a receptor [CRF2(a)] but not CRF2(b) and CRF2(c) was observed in higher passage cultures of human Y79 retinoblastoma cells. Functional studies further demonstrated an increase in CRF2(
Autor:
J. Adriaan Bouwknecht, Thomas Steckler, Jesús Alcázar, Frank M. Dautzenberg, Abdellah Ahnaou, Wilhelmus Drinkenburg
Publikováno v:
European Journal of Pharmacology. 579:177-188
Melanin-concentrating hormone (MCH) is a hypothalamic peptide that centrally regulates food intake, energy balance and emotion. Interestingly, MCH and melanin-concentrating hormone MCH(1) receptors are distributed in brain areas known to regulate vig
Publikováno v:
Endocrinology. 146:4851-4860
Several corticotropin-releasing factor (CRF) family genes have been identified in vertebrates. Mammals have four paralogous genes that encode CRF or the urocortins 1, 2, and 3. In teleost fishes, a CRF, urotensin I (a fish ortholog of mammalian uroco
Publikováno v:
Neuropharmacology. 48:1043-1055
The human Neuropeptide Y (NPY) receptors 1 (hY1), 2 (hY2), 4 (hY4), and the mouse type 5 (mY5) receptor were expressed in human embryonic kidney 293 (HEK293) cells. The receptors bound a radioiodinated NPY ligand with high affinity and various NPY an