Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Frank M Mason"'
Autor:
Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, Brianna N Smith, Macey J Slota, Elizabeth M Reynolds, Soumita Goswami, Michael R Savona, Frank M Mason, Taekyu Lee, Stephen Fesik, Qi Liu, William P Tansey
Publikováno v:
eLife, Vol 12 (2024)
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the ‘WIN’ site that tethers WDR5 to chromatin. WIN site inhibi
Externí odkaz:
https://doaj.org/article/843d9e309e8c4e569cdd20374b77da61
Autor:
Ann Hanna, Mellissa J. Nixon, M. Valeria Estrada, Violeta Sanchez, Quanhu Sheng, Susan R. Opalenik, Abigail L. Toren, Joshua Bauer, Phillip Owens, Frank M. Mason, Rebecca S. Cook, Melinda E. Sanders, Carlos L. Arteaga, Justin M. Balko
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-16 (2022)
Abstract Aim Deregulated signaling pathways are a hallmark feature of oncogenesis and driver of tumor progression. Dual specificity protein phosphatase 4 (DUSP4) is a critical negative regulator of the mitogen-activated protein kinase (MAPK) pathway
Externí odkaz:
https://doaj.org/article/6aa7b57ed41b4bac96b6712182f77f69
Autor:
Kathryn E. Beckermann, Rachel Hongo, Xiang Ye, Kirsten Young, Katie Carbonell, Diana C. Contreras Healey, Peter J. Siska, Sierra Barone, Caroline E. Roe, Christof C. Smith, Benjamin G. Vincent, Frank M. Mason, Jonathan M. Irish, W. Kimryn Rathmell, Jeffrey C. Rathmell
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Metabolic reprogramming dictates the fate and function of stimulated T cells, yet these pathways can be suppressed in T cells in tumor microenvironments. We previously showed that glycolytic and mitochondrial adaptations directly contribute to reduci
Externí odkaz:
https://doaj.org/article/862d5c6aeea34684826804171f88d2e8
Autor:
W. Kimryn Rathmell, Cheryl L. Walker, Ruhee Dere, Joel S. Parker, Brian D. Strahl, Ian J. Davis, Abid Khan, Aguirre A. de Cubas, Yihsuan S. Tsai, Ryoma Ohi, Reid T. Powell, Pratim Chowdhury, Bo-Hwa Sohn, Charles B. Shuster, Menuka Karki, Catherine C. Fahey, Frank M. Mason, Durga Nand Tripathi, Esteban A. Terzo, In-Young Park, Yun-Chen Chiang
Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests haploinsufficiency for 3p tumor suppressors as early drivers of tumorigenesis. We previously repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b405439d92a4d44007c6c967ae1a3cf
https://doi.org/10.1158/0008-5472.c.6510453
https://doi.org/10.1158/0008-5472.c.6510453
Autor:
W. Kimryn Rathmell, Cheryl L. Walker, Ruhee Dere, Joel S. Parker, Brian D. Strahl, Ian J. Davis, Abid Khan, Aguirre A. de Cubas, Yihsuan S. Tsai, Ryoma Ohi, Reid T. Powell, Pratim Chowdhury, Bo-Hwa Sohn, Charles B. Shuster, Menuka Karki, Catherine C. Fahey, Frank M. Mason, Durga Nand Tripathi, Esteban A. Terzo, In-Young Park, Yun-Chen Chiang
SETD2 loss promotes chromosomal abnormalities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cf572946bacc7499a8f3ac9594ff59
https://doi.org/10.1158/0008-5472.22419723.v1
https://doi.org/10.1158/0008-5472.22419723.v1
Autor:
W. Kimryn Rathmell, Cheryl L. Walker, Ruhee Dere, Joel S. Parker, Brian D. Strahl, Ian J. Davis, Abid Khan, Aguirre A. de Cubas, Yihsuan S. Tsai, Ryoma Ohi, Reid T. Powell, Pratim Chowdhury, Bo-Hwa Sohn, Charles B. Shuster, Menuka Karki, Catherine C. Fahey, Frank M. Mason, Durga Nand Tripathi, Esteban A. Terzo, In-Young Park, Yun-Chen Chiang
fig legends for sup figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14971053ddde6dac6e1a07f8b4f7587d
https://doi.org/10.1158/0008-5472.22419699
https://doi.org/10.1158/0008-5472.22419699
Autor:
Darren R. Heintzman, Joel Elasy, Channing Chi, Xiang Ye, Evan S. Krystoviak, Wasay Khan, Lana Olson, Angela Jones, Kelsey Voss, Andrew R. Patterson, Ayaka Sugiura, Frank M. Mason, Hanna S. Hong, Lindsay Bass, Katherine L. Beier, Wentao Deng, Costas A. Lyssiotis, Alexander G. Bick, W. Kimryn Rathmell, Jeffrey C. Rathmell
Heat is a cardinal feature of inflammation. Despite temperature variability and dependence of enzymes and complexes, how heat and fever affect immune cells remains uncertain. We found that heat broadly increased inflammatory activity of CD4+T cell su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58b80dffaeb56014c0a7e92eae5c7b0f
https://doi.org/10.1101/2022.11.14.516478
https://doi.org/10.1101/2022.11.14.516478
Autor:
Frank M. Mason, Emily S. Kounlavong, Anteneh T. Tebeje, Rashmi Dahiya, Tiffany Guess, Logan Vlach, Stephen R. Norris, Courtney A. Lovejoy, Ruhee Dere, Ryoma Ohi, Peter Ly, Cheryl L. Walker, W. Kimryn Rathmell
SummaryFactors governing the faithful replication of chromosomes are essential for cellular and genomic integrity. While a variety of mechanisms to manage breaks and promote repair of DNA are widely recognized, epigenetic landmarks that preserve telo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0254fa548e9d47cb41bf2f2df61c525
https://doi.org/10.1101/2022.10.25.513694
https://doi.org/10.1101/2022.10.25.513694
Autor:
Bradley I. Reinfeld, Andrew R. Patterson, Rachel E. Brown, Allison S. Cohen, Matthew H. Wilson, Anna Chytil, M. Noor Tantawy, Vera M. Todd, W. David Merryman, Jeffrey C. Rathmell, H. Charles Manning, Matthew G. Vander Heiden, Jackie E. Bader, Matthew Z. Madden, Abin Abraham, Alexander Muir, Frank M. Mason, Ahmed Ali, Christopher S. Williams, Richard T. O’Neil, Brian T. Do, Ayaka Sugiura, Tessa Huffstater, Kirsten Young, Rachelle W. Johnson, Caroline A. Lewis, Melissa M. Wolf, Emily F. Mason, Katherine E. Beckermann, W. Kimryn Rathmell, Fuxue Xin, Rachel Hongo
Publikováno v:
Nature. 593:282-288
Cancer cells characteristically consume glucose through Warburg metabolism1, a process that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-infiltrating immune cells also rely on glucose, and impaired immune cell metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd19c20858dbb625ae521c410a238aec
https://doi.org/10.1038/s41586-021-03442-1
https://doi.org/10.1038/s41586-021-03442-1
Autor:
Ann Hanna, Mellissa J. Nixon, M. Valeria Estrada, Violeta Sanchez, Quanhu Sheng, Susan R. Opalenik, Abigail L. Toren, Joshua Bauer, Phillip Owens, Frank M. Mason, Rebecca S. Cook, Melinda E. Sanders, Carlos L. Arteaga, Justin M. Balko
Publikováno v:
Breast cancer research : BCR. 24(1)
Aim Deregulated signaling pathways are a hallmark feature of oncogenesis and driver of tumor progression. Dual specificity protein phosphatase 4 (DUSP4) is a critical negative regulator of the mitogen-activated protein kinase (MAPK) pathway and is of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86c8655c33a24b2d8196bc077eaadc2
https://pubmed.ncbi.nlm.nih.gov/35850776
https://pubmed.ncbi.nlm.nih.gov/35850776