Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Frank M, Boeckler"'
Publikováno v:
Frontiers in Chemistry, Vol 9 (2022)
Fragment-based drug discovery is one of the most utilized approaches for the identification of novel weakly binding ligands, by efficiently covering a wide chemical space with rather few compounds and by allowing more diverse binding modes to be foun
Externí odkaz:
https://doaj.org/article/c476b76c0c654f17934ff5b5e83bb90a
Autor:
Heba H. A. Hassan, Muhammad I. Ismail, Mohammed A. S. Abourehab, Frank M. Boeckler, Tamer M. Ibrahim, Reem K. Arafa
Publikováno v:
Molecules, Vol 28, Iss 3, p 1296 (2023)
Fascin is an actin-bundling protein overexpressed in various invasive metastatic carcinomas through promoting cell migration and invasion. Therefore, blocking Fascin binding sites is considered a vital target for antimetastatic drugs. This inspired u
Externí odkaz:
https://doaj.org/article/250b1a3853dd4315900044dce54e6223
Autor:
Thomas Majer, Keshab Bhattarai, Jan Straetener, Justus Pohlmann, Patrick Cahill, Markus O. Zimmermann, Marc P. Hübner, Marcel Kaiser, Johan Svenson, Michael Schindler, Heike Brötz-Oesterhelt, Frank M. Boeckler, Harald Gross
Publikováno v:
Marine Drugs, Vol 20, Iss 8, p 532 (2022)
Two new ircinianin-type sesterterpenoids, ircinianin lactone B and ircinianin lactone C (7 and 8), together with five known entities from the ircinianin compound family (1, 3–6) were isolated from the marine sponge Ircinia wistarii. Ircinianin lact
Externí odkaz:
https://doaj.org/article/81201b1953774ebdb89e3abda1c4df48
Publikováno v:
Drug Design, Development and Therapy. 17:1247-1274
Sebastian Vaas,1 Markus O Zimmermann,1 Theresa Klett,1 Frank M Boeckler1,2 1Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, Laboratory for Molecular Design and Pharmaceutical Biophysics, Institute of Pharmaceutical
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
The coronavirus disease 19 (COVID-19) is a rapidly growing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its papain-like protease (SARS-CoV-2 PLpro) is a crucial target to halt virus replication. SARS-CoV PLpro
Externí odkaz:
https://doaj.org/article/76eb038cfc314617842c78c32b022d99
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 12361-12368 (2018)
Externí odkaz:
https://doaj.org/article/2420f0fdc1fe4cddae1ec7a593d7acd4
Autor:
Francesco Ansideri, Joana T. Macedo, Michael Eitel, Ahmed El-Gokha, Dhafer S. Zinad, Camilla Scarpellini, Mark Kudolo, Dieter Schollmeyer, Frank M. Boeckler, Bärbel S. Blaum, Stefan A. Laufer, Pierre Koch
Publikováno v:
ACS Omega, Vol 3, Iss 7, Pp 7809-7831 (2018)
Externí odkaz:
https://doaj.org/article/d337085c21624f4fbd7965216a3191ad
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Halogen bonds have recently gained attention in life sciences and drug discovery. However, it can be difficult to harness their full potential, when newly introducing them into an established hit or lead structure by molecular design. A possible solu
Externí odkaz:
https://doaj.org/article/c739adb7f73e4538a400671e2389639a
Autor:
Jason Stahlecker, Theresa Klett, Martin Schwer, Simon Jaag, Marcel Dammann, Larissa N. Ernst, Michael B. Braun, Markus O. Zimmermann, Markus Kramer, Michael Lämmerhofer, Thilo Stehle, Murray Coles, Frank M. Boeckler
Publikováno v:
RSC Medicinal Chemistry. 13:1575-1586
The cellular tumor antigen p53 is a key component in cell cycle control. The mutation Y220C heavily destabilizes the protein thermally but yields a druggable crevice. We have screened the diversity-optimized halogen-enriched fragment library against
Autor:
Christoph Ernst, Johannes Heidrich, Catharina Sessler, Julia Sindlinger, Dirk Schwarzer, Pierre Koch, Frank M. Boeckler
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Phage display-selected bicyclic peptides have already shown their great potential for the development as bioactive modulators of therapeutic targets. They can provide enhanced proteolytic stability and improved membrane permeability. Molecular design
Externí odkaz:
https://doaj.org/article/2e10cff4962d49c689e6eb103dcd1465