Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Frank Leithäuser"'
Autor:
Lap Kwan Chan, Miltiadis Tsesmelis, Melanie Gerstenlauer, Frank Leithäuser, Alexander Kleger, Lukas Daniel Frick, Harald Jacob Maier, Thomas Wirth
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
A model of autoimmune pancreatitis is developed by blocking the activation of NF-κB in pancreatic stellate cells, via conditional deletion of NEMO (IKKγ), which presents strong pancreatic inflammation with eosinophilia after the induction of chroni
Externí odkaz:
https://doaj.org/article/80177109f28e4bcf87f4e4ede8c9e652
Autor:
Julia Richter, Anna-Laura Kretz, Johannes Lemke, Michael Fauler, Jens-Uwe Werner, Stephan Paschke, Frank Leithäuser, Doris Henne-Bruns, Andreas Hillenbrand, Uwe Knippschild
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Colorectal cancer (CRC) is the fourth leading cause of cancer related deaths worldwide and prognosis in advanced tumor stage still remains poor. Since CK1 isoforms have been reported to be deregulated in several tumor entities CK1
Externí odkaz:
https://doaj.org/article/6d4e9e96e1404c6cb37051e5666715dd
Publikováno v:
Diagnostics, Vol 11, Iss 6, p 1123 (2021)
It is well recognized that the AP-1 transcription factor BATF3 is constitutively expressed in Hodgkin/Reed-Sternberg (HRS) cells, but its potential as a diagnostic marker for classical Hodgkin lymphoma (cHL) has not yet been addressed. In this study,
Externí odkaz:
https://doaj.org/article/b495e3d14c834e48be283131f6495d21
Autor:
Anna-Laura Kretz, Monika Schaum, Julia Richter, Ella F Kitzig, Christine C Engler, Frank Leithäuser, Doris Henne-Bruns, Uwe Knippschild, Johannes Lemke
Publikováno v:
Tumor Biology, Vol 39 (2017)
Despite recent advances in diagnosis and therapy, prognosis of pancreatic cancer still remains very poor. Besides valid prognostic markers, novel therapeutic approaches are urgently needed. The family of cyclin-dependent kinases comprises 20 kinases
Externí odkaz:
https://doaj.org/article/d350ef6995294c2daddcdfd36e4a72b6
Autor:
Heidrun Hirner, Cagatay Günes, Joachim Bischof, Sonja Wolff, Arnhild Grothey, Marion Kühl, Franz Oswald, Florian Wegwitz, Michael R Bösl, Anna Trauzold, Doris Henne-Bruns, Christian Peifer, Frank Leithäuser, Wolfgang Deppert, Uwe Knippschild
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29709 (2012)
Simian virus 40 (SV40) is a powerful tool to study cellular transformation in vitro, as well as tumor development and progression in vivo. Various cellular kinases, among them members of the CK1 family, play an important role in modulating the transf
Externí odkaz:
https://doaj.org/article/6c146078ced546758b3690d263e2f982
Autor:
Jürgen Löhler, Heidrun Hirner, Bernhard Schmidt, Klaus Kramer, Dietmar Fischer, Dietmar R Thal, Frank Leithäuser, Uwe Knippschild
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4174 (2009)
BackgroundCasein kinase 1 delta (CK1delta) phosphorylates many key proteins playing important roles in such biological processes as cell growth, differentiation, apoptosis, circadian rhythm and vesicle transport. Furthermore, deregulation of CK1delta
Externí odkaz:
https://doaj.org/article/b70796d713fc4b4a92b4b3c74e7b4dc3
Autor:
Frank Leithäuser, Peter Möller, Olga Ritz, Karola Dorsch, Thomas F. Barth, Silke Brüderlein, Beate Wotschke, Gerhard Moldenhauer, Sergey W. Popov
Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) in activated B lymphocytes and is potentially implicated in genomic instability of B-cell malignancies. For unknown reasons, B-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9757f84fd1c0a19404982308b8b51d2a
https://doi.org/10.1158/0008-5472.c.6494784.v1
https://doi.org/10.1158/0008-5472.c.6494784.v1
Autor:
Frank Leithäuser, Peter Möller, Olga Ritz, Karola Dorsch, Thomas F. Barth, Silke Brüderlein, Beate Wotschke, Gerhard Moldenhauer, Sergey W. Popov
Supplementary Table 1 from Target Sequence Accessibility Limits Activation-Induced Cytidine Deaminase Activity in Primary Mediastinal B-Cell Lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b907a5f185d6d81a289b45a05d5f2a6
https://doi.org/10.1158/0008-5472.22365621
https://doi.org/10.1158/0008-5472.22365621
Publikováno v:
Methods in cell biology. 168
For more than 50years, hematopoietic stem cell transplantation (HSCT) has been the major curative therapy for hematological malignancies and genetic disorders, but its success is limited by the development of graft-versus-host disease (GVHD). GVHD re
Publikováno v:
Methods in Cell Biology ISBN: 9780323899451
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2329b7324ea0240dc7fc65ae4d3bf62d
https://doi.org/10.1016/bs.mcb.2021.12.007
https://doi.org/10.1016/bs.mcb.2021.12.007