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pro vyhledávání: '"Frank Le-Strat"'
Autor:
Yi Li, Gejing Deng, Vinod Patel, Dmitri Wiederschain, Ming Yin, Chaomei Shi, Olivier Bedel, Magali Mathieu, Stefan Gross, Aurelie Vassort, Qiang Gao, Frank Le-Strat, Alexey Rak, Bailin Zhang, Junqing Shen, Timothy He, Ying Zhang, Eamonn Rooney, Francisco Adrian, Patricia Gee, Walter Englaro, Hong Cheng, Dietmar Hoffmann, Jean-Pierre Marquette, Larry R. McLean, Jessica McManus, Stuart Licht
Publikováno v:
Journal of Biological Chemistry. 290:762-774
Cancer-associated point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) confer a neomorphic enzymatic activity: the reduction of α-ketoglutarate to d-2-hydroxyglutaric acid, which is proposed to act as an oncogenic metabolite by induci