Výsledky vyhledávání - "Frank L Rice"

Akademický článek

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin.

Autor: Frank L Rice, George Houk, James P Wymer, Sara J C Gosline, Justin Guinney, Jianqiang Wu, Nancy Ratner, Michael P Jankowski, Salvo La Rosa, Marilyn Dockum, James R Storey, Steven L Carroll, Phillip J Albrecht, Vincent M Riccardi

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0216527 (2019)

In addition to large plexiform neurofibromas (pNF), NF1 patients are frequently disfigured by cutaneous neurofibromas (cNF) and are often afflicted with chronic pain and itch even from seemingly normal skin areas. Both pNFs and cNF consist primarily

Externí odkaz: https://doaj.org/article/7ed7cfa28c9741e981749ceacff2bc19

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Akademický článek

Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels.

Autor: Travis P Barr, Phillip J Albrecht, Quanzhi Hou, Alexander A Mongin, Gary R Strichartz, Frank L Rice

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56744 (2013)

Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis. In this study, we analyzed ATP release from cultured human

Externí odkaz: https://doaj.org/article/6b58a4d6c11f4120b2aba2f5674690af

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Akademický článek

Cutaneous targets for topical pain medications in patients with neuropathic pain: individual differential expression of biomarkers supports the need for personalized medicine

Autor: Phillip J. Albrecht, Yi Liu, George Houk, Beth Ruggiero, Daniel Banov, Marilyn Dockum, A.J. Day, Frank L. Rice, Gus Bassani

Publikováno v: PAIN Reports, Vol 9, Iss 2, p e1119 (2024)

Abstract. Introduction:. Numerous potential cutaneous targets exist for treating chronic pain with topically applied active pharmaceutical ingredients. This preliminary human skin tissue investigation was undertaken to characterize several key biomar

Externí odkaz: https://doaj.org/article/a731f1b198674952b32cdbc9b7d4b130

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Akademický článek

Human-like cutaneous neuropathologies associated with a porcine model of peripheral neuritis: A translational platform for neuropathic pain

Autor: Frank L. Rice, David Castel, Elizabeth Ruggiero, Marilyn Dockum, George Houk, Itai Sabbag, Phillip J. Albrecht, Sigal Meilin

Publikováno v: Neurobiology of Pain, Vol 5, Iss , Pp - (2019)

Despite enormous investment in research and development of novel treatments, there remains a lack of predictable, effective, and safe therapeutics for human chronic neuropathic pain (NP) afflictions. NP continues to increase among the population and

Externí odkaz: https://doaj.org/article/49668ddd5d1e4dee9d87ab294995a05f

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A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse

Autor: Lawrence M. Carey, Ken Mackie, Zhili Xu, Xiaoyan Lin, Phillip J. Albrecht, Cecilia J. Hillard, Marilyn Dockum, Alexandros Makriyannis, George Houk, Andrea G. Hohmann, Frank L. Rice, Julián Romero, Elizabeth Ruggiero

Publikováno v: DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
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CB2 cannabinoid receptors (CB2) are a promising therapeutic target that lacks unwanted side effects of CB1 activation. However, the cell types expressing CB2 that mediate these effects remain poorly understood. We used transgenic mice with CB2 promot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f163d21d468873844a34475665c7bd77
https://doi.org/10.1097/j.pain.0000000000002502

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Keratinocyte Biomarkers Distinguish Painful Diabetic Peripheral Neuropathy Patients and Correlate With Topical Lidocaine Responsiveness

Autor: Phillip J. Albrecht, George Houk, Elizabeth Ruggiero, Marilyn Dockum, Margaret Czerwinski, Joseph Betts, James P. Wymer, Charles E. Argoff, Frank L. Rice

Publikováno v: Frontiers in Pain Research, Vol 2 (2021)

This study investigated quantifiable measures of cutaneous innervation and algesic keratinocyte biomarkers to determine correlations with clinical measures of patient pain perception, with the intent to better discriminate between diabetic patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1b5931d1e01c174ede38090802cce1
https://doi.org/10.3389/fpain.2021.790524

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Specializations of somatosensory innervation in the skin of humpback whales (Megaptera novaeangliae)

Autor: Sherri A. Eldridge, Farzad Mortazavi, Frank L. Rice, Darlene R. Ketten, David N. Wiley, Ed Lyman, Joy S. Reidenberg, Frederike D. Hanke, Steffen DeVreese, Sarah McKay Strobel, Douglas L. Rosene

Publikováno v: Anatomical record (Hoboken, N.J. : 2007)REFERENCES. 305(3)

Cetacean behavior and life history imply a role for somatosensory detection of critical signals unique to their marine environment. As the sensory anatomy of cetacean glabrous skin has not been fully explored, skin biopsy samples of the flank skin of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d3cb05fa2dc912f9156581bc4b076e
https://pubmed.ncbi.nlm.nih.gov/35023618

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32-LB: Early Selective Loss of CGRP Sensory Innervation to Cutaneous Arterioles May Be an Early Prediabetic Feature Developing prior to the Onset of Overt Type 2 Diabetes (T2D) in Rhesus Monkeys and Humans Instead of Being a Consequence

Autor: Barbara C. Hansen, Phillip J. Albrecht, Frank L. Rice, Xenia Tigno, George Houk

Publikováno v: Diabetes. 69

Vasculopathy complications of T2D cause limited tissue perfusion, ulcers, and often amputation. Mechanisms underlying T2D vasculopathy remain ambiguous. Compare to normal controls, multi-molecular immunofluorescence of glabrous hand and foot skin bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37ad7925626ba00e22cd8013bb207912
https://doi.org/10.2337/db20-32-lb

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Human-like cutaneous neuropathologies associated with a porcine model of peripheral neuritis: A translational platform for neuropathic pain

Autor: Elizabeth Ruggiero, David Castel, Itai Sabbag, Frank L. Rice, Sigal Meilin, George Houk, Marilyn Dockum, Phillip J. Albrecht

Publikováno v: Neurobiology of Pain, Vol 5, Iss, Pp-(2019)
Neurobiology of Pain

Highlights • Pig peripheral neuritis trauma model mimics cutaneous human pathologies. • Pig skin anatomically similar to humans, unlike rodent. • Pig PNT model provides better data than rodent for translational pain research.
Despite enorm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d126256c6a0f6da2615513c8d4c92e5
http://www.sciencedirect.com/science/article/pii/S2452073X1830014X

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