High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia

Autor: Priscilla Wander, Susan T.C.J.M. Arentsen-Peters, Sandra S. Pinhanҫos, Bianca Koopmans, M.Emmy M. Dolman, Rijndert Ariese, Frank L. Bos, Patricia Garrido Castro, Luke Jones, Pauline Schneider, Miriam Guillen Navarro, Jan J. Molenaar, Anne C. Rios, C. Michel Zwaan, Ronald W. Stam

Publikováno v: Translational Oncology, Vol 14, Iss 5, Pp 101048- (2021)

Pediatric MLL-rearranged acute myeloid leukemia (AML) has a generally unfavorable outcome, primarily due to relapse and drug resistance. To overcome these difficulties, new therapeutic agents are urgently needed. Yet, implementing novel drugs for cli

Externí odkaz: https://doaj.org/article/57a41e03969a4ac29001dea5f981bde1

Supplementary Figures 1-5, Table 1 from Molecular Causes for BUBR1 Dysfunction in the Human Cancer Predisposition Syndrome Mosaic Variegated Aneuploidy

Autor: Geert J.P.L. Kops, Nazneen Rahman, Sandra Hanks, Frank L. Bos, Maria H.J. van Osch, Saskia J.E. Suijkerbuijk

Supplementary Figures 1-5, Table 1 from Molecular Causes for BUBR1 Dysfunction in the Human Cancer Predisposition Syndrome Mosaic Variegated Aneuploidy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e897a1e0c8d5a6c62cfee238d2b85e6
https://doi.org/10.1158/0008-5472.22382025.v1

Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D

Autor: Maria Alieva, Frank L. Bos, Anne C. Rios, Ellen J. Wehrens, Johanna F. Dekkers, Michiel Kleinnijenhuis, Hannah Johnson, Jarno Drost, Clara Martínez Mir, Raimond Heukers, Mario Barrera Roman, Sam de Blank, Esmée J. van Vliet, Ravian L. van Ineveld, Susana M. Chuva de Sousa Lopes

Publikováno v: Nature Biotechnology
Nature Biotechnology, 39(10), 1239-1245. NATURE RESEARCH

Despite advances in three-dimensional (3D) imaging, it remains challenging to profile all the cells within a large 3D tissue, including the morphology and organization of the many cell types present. Here, we introduce eight-color, multispectral, lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bda6aec3ffafefa2656c82b7b58eca
https://doi.org/10.1038/s41587-021-00926-3

Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D

Autor: Ravian L, van Ineveld, Michiel, Kleinnijenhuis, Maria, Alieva, Sam, de Blank, Mario, Barrera Roman, Esmée J, van Vliet, Clara, Martínez Mir, Hannah R, Johnson, Frank L, Bos, Raimond, Heukers, Susana M, Chuva de Sousa Lopes, Jarno, Drost, Johanna F, Dekkers, Ellen J, Wehrens, Anne C, Rios

Publikováno v: Nature biotechnology. 39(10)

Despite advances in three-dimensional (3D) imaging, it remains challenging to profile all the cells within a large 3D tissue, including the morphology and organization of the many cell types present. Here, we introduce eight-color, multispectral, lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e361d7d33bf4d921439a4a12533196f5
https://pubmed.ncbi.nlm.nih.gov/36045261

Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice

Autor: Ann C. Zovein, John S. Hawkins, Prajakta Ghatpande, Carlos Lizama, Frank L. Bos, Jerry Lee, Yongbo Peng, Giorgio Lagna, Joan P. Zape, Akiko Hata, Xuan Jiang, Justin Louie

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature communications, vol 8, iss 1
Jiang, X; Hawkins, JS; Lee, J; Lizama, CO; Bos, FL; Zape, JP; et al.(2017). Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. NATURE COMMUNICATIONS, 8. doi: 10.1038/s41467-017-00137-y. UCSF: Retrieved from: http://www.escholarship.org/uc/item/22b5c9x9

Hematopoietic stem and progenitor cells arise from the vascular endothelium of the dorsal aorta and subsequently switch niche to the fetal liver through unknown mechanisms. Here we report that vascular endothelium-specific deletion of mouse Drosha (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0823d90e39dbfe036c6f4b0292515534
https://doaj.org/article/811b54bd0de3489e841c1856c5f439e4