Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Frank Kozielski"'
Autor:
Jiazhi Tang, Cheng Zhang, Nuria Codina Castillo, Christophe J. Lalaurie, Xin Gao, Paul A. Dalby, Frank Kozielski
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Antibody-fragment (Fab) therapy development has the potential to be accelerated by computational modelling and simulations that predict their target binding, stability, formulation, manufacturability, and the impact of further protein engine
Externí odkaz:
https://doaj.org/article/821ca3cb011b454cb4dbf4b1591c569d
Autor:
Huan Wang, Syed RA Rizvi, Danni Dong, Jiaqi Lou, Qian Wang, Watanyoo Sopipong, Yufeng Su, Fares Najar, Pratul K Agarwal, Frank Kozielski, Shozeb Haider
Publikováno v:
eLife, Vol 12 (2023)
The coronavirus SARS-CoV-2 protects its RNA from being recognized by host immune responses by methylation of its 5’ end, also known as capping. This process is carried out by two enzymes, non-structural protein 16 (NSP16) containing 2’-O-methyltr
Externí odkaz:
https://doaj.org/article/aaf969c4d991460793c33d2ab25f86d6
Autor:
Wolfgang Knecht, S. Zoë Fisher, Jiaqi Lou, Céleste Sele, Shumeng Ma, Anna Andersson Rasmussen, Nikos Pinotsis, Frank Kozielski
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13649 (2023)
The β-coronavirus family, encompassing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Severe Acute Respiratory Syndrome Coronavirus (SARS), and Middle East Respiratory Syndrome Coronavirus (MERS), has triggered pandemics within the la
Externí odkaz:
https://doaj.org/article/3053d2a147a84cf6b0ab76f0545180b8
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11197 (2023)
The identification of multiple simultaneous orientations of small molecule inhibitors binding to a protein target is a common challenge. It has recently been reported that the conformational heterogeneity of ligands is widely underreported in the Pro
Externí odkaz:
https://doaj.org/article/8f2b6e741dd74d9989c221c960d6629a
Autor:
Alberto Borsatto, Obaeda Akkad, Ioannis Galdadas, Shumeng Ma, Shymaa Damfo, Shozeb Haider, Frank Kozielski, Carolina Estarellas, Francesco Luigi Gervasio
Publikováno v:
eLife, Vol 11 (2022)
Non-structural protein 1 (Nsp1) is a main pathogenicity factor of α- and β-coronaviruses. Nsp1 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suppresses the host gene expression by sterically blocking 40S host ribosomal subunits an
Externí odkaz:
https://doaj.org/article/bb41995f76cd4784b965708fe465be40
Autor:
Cheng Zhang, Nuria Codina, Jiazhi Tang, Haoran Yu, Nesrine Chakroun, Frank Kozielski, Paul A. Dalby
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2726-2741 (2021)
Successful development of protein therapeutics depends critically on achieving stability under a range of conditions. A deeper understanding of the drivers of instability across different stress conditions, will enable the engineering of more robust
Externí odkaz:
https://doaj.org/article/b59a28092c0f416f8bb210089774ee83
Autor:
Shumeng Ma, Shymaa Damfo, Jiaqi Lou, Nikos Pinotsis, Matthew W. Bowler, Shozeb Haider, Frank Kozielski
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12448 (2022)
The regular reappearance of coronavirus (CoV) outbreaks over the past 20 years has caused significant health consequences and financial burdens worldwide. The most recent and still ongoing novel CoV pandemic, caused by Severe Acute Respiratory Syndro
Externí odkaz:
https://doaj.org/article/a2cbfefdbcc24833810fec21fce9177f
Autor:
Federica Riccio, Sandeep K. Talapatra, Sally Oxenford, Richard Angell, Michela Mazzon, Frank Kozielski
Publikováno v:
Biology Open, Vol 8, Iss 1 (2019)
Members of the Flaviviridae family constitute a severe risk to human health. Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue
Externí odkaz:
https://doaj.org/article/7ebbf2718c8a46fb9e0fe59acf380169
Autor:
Annika Rogstam, Maria Nyblom, Signe Christensen, Celeste Sele, Vladimir O. Talibov, Therese Lindvall, Anna Andersson Rasmussen, Ingemar André, Zoë Fisher, Wolfgang Knecht, Frank Kozielski
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7375 (2020)
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), causing Coronavirus Disease 19 (COVID-19), emerged at the end of 2019 and quickly spread to cause a global pandemic with severe socio-economic consequences. The early sequencing of its RNA
Externí odkaz:
https://doaj.org/article/57cd175546654db088052c457278b183
Autor:
Jiazhi Tang, Cheng Zhang, Nuria Codina Castillo, Christophe Lalaurie, Xin Gao, Paul Dalby, Frank Kozielski
Antibody-fragment (Fab) therapy development has the potential to be accelerated by computational modelling and simulations that predict their target binding, stability, formulation, manufacturability, and the impact of further protein engineering. Su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47ca7e2ecf36c481ff56b75247c4a9d1
https://doi.org/10.21203/rs.3.rs-2741682/v1
https://doi.org/10.21203/rs.3.rs-2741682/v1