Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Frank Kerrigan"'
The purpose of this document is to provide details of the integration strategy, high level conceptual architecture and the recommended underlying approaches for delivery that will be required to help achieve the goals of the Jisc research data shared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ac81fa9053a61ab7542a8b4603af444
Publikováno v:
Journal of Medicinal Chemistry. 42:3342-3355
A series of N-substituted 1-(2,3-dihydro-1, 4-benzodioxin-2-yl)methylamine derivatives with D(2) antagonist/5-HT(1A) partial agonist activity has been prepared as potential atypical antipsychotic agents. Optimization of in vitro receptor binding acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7d6f86d64dcb0a9990cba0e15b5c81
https://doi.org/10.1021/jm9910122
https://doi.org/10.1021/jm9910122
Autor:
Frank Kerrigan, Adrian J. Fisher
Publikováno v:
Synthetic Communications. 28:2959-2968
A safe and efficient process has been developed for the multigram synthesis of 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2-diol (iso-MHPG) 2, via osmium-catalysed dihydroxylation of 3-benzyloxy-4-methoxystyrene 5, and subsequent debenzylation. The method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a6f9f3aff41f162f5c589732fd6f6b7
https://doi.org/10.1080/00397919808004875
https://doi.org/10.1080/00397919808004875
Autor:
Frank Kerrigan
Publikováno v:
Expert Opinion on Therapeutic Patents. 8:439-460
Whilst considerable advances have been made in the treatment of depression, particularly with the advent of the selective serotonin re-uptake inhibitors (SSRIs), current drug treatments are unsatisfactory for several reasons. In particular, they fail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeb6641a8142b92e57a3e347800e747b
https://doi.org/10.1517/13543776.8.4.439
https://doi.org/10.1517/13543776.8.4.439
Publikováno v:
Tetrahedron Letters. 39:2219-2222
Reaction of a series of bicyclic bromoarenes with N-tert-butoxycarbonylpiperazine (N-Boc-piperazine) under palladium-catalysed coupling conditions followed by routine removal of the Boc group with trifluoroacetic acid in dichloromethane gave the corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9ae8c48c8345bbf8fb15ec25373cc2c
https://doi.org/10.1016/s0040-4039(98)00179-8
https://doi.org/10.1016/s0040-4039(98)00179-8
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85eada77b179d9e024eab7cdfff791df
https://doi.org/10.1002/chin.199645203
https://doi.org/10.1002/chin.199645203
Publikováno v:
ChemInform. 28
Synthetic routes to N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine (sibutramine) 1 and its demethylated and hydroxylated human metabolites N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-methylamine 2, 1-[1-(4-chlorophenyl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::825fed3849dc39a82b7ef5f7bf285be1
https://doi.org/10.1002/chin.199734105
https://doi.org/10.1002/chin.199734105
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d71e295e60e853df31de0ddfe84ab468
https://doi.org/10.1002/chin.199827205
https://doi.org/10.1002/chin.199827205
Autor:
Adrian J. Fisher, Frank Kerrigan
Publikováno v:
ChemInform. 29
A safe and efficient process has been developed for the multigram synthesis of 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2-diol (iso-MHPG) 2, via osmium-catalysed dihydroxylation of 3-benzyloxy-4-methoxystyrene 5, and subsequent debenzylation. The method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10c89c7a0d491c3fd8ab83bdbde3b3fb
https://doi.org/10.1002/chin.199849109
https://doi.org/10.1002/chin.199849109
Autor:
Lesley Dixon, Jan Drzewiecki, Graeme C. M. Smith, Keith Allan Menear, Krystyna J. Dillon, Xiao-Ling Fan Cockcroft, Frank Kerrigan, Niall M. B. Martin, Vincent M. Loh
Publikováno v:
ChemInform. 37
We have previously described the discovery of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors based on a phthalazinone scaffold. Subsequent optimisation of inhibitory activity, metabolic stability and pharmacokinetic parameters has led to a novel se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b141432495a1fecbf7ee6b92e1d55a5
https://doi.org/10.1002/chin.200621153
https://doi.org/10.1002/chin.200621153