Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Frank K. Huynh"'
Autor:
Eva Tudurí, Maria M. Glavas, Ali Asadi, Robert K. Baker, Cara E. Ellis, Galina Soukhatcheva, Marjolaine Philit, Frank K. Huynh, James D. Johnson, C. Bruce Verchere, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract The study of primary glucagon-secreting α-cells is hampered by their low abundance and scattered distribution in rodent pancreatic islets. We have designed a double-stranded adeno-associated virus containing a rat proglucagon promoter (700
Externí odkaz:
https://doaj.org/article/556a5308d1314702b2cd07d70fc68443
Autor:
Shoshana Naiman, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, Matan Y. Avivi, Asael Roichman, Yariv Kanfi, Asaf A. Gertler, Tirza Doniger, Olga R. Ilkayeva, Ifat Abramovich, Orly Yaron, Batia Lerrer, Eyal Gottlieb, Robert A. Harris, Doron Gerber, Matthew D. Hirschey, Haim Y. Cohen
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4127-4143.e8 (2019)
Summary: The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling, known to regulate multiple metabolic pathways. SIRT6 binds PPARα a
Externí odkaz:
https://doaj.org/article/d5de3d9672bd4669986a28b46e0384ff
Autor:
Ifat Abramovich, Doron Gerber, Matthew D. Hirschey, Olga Ilkayeva, Yael Shahar, Asaf A. Gertler, Asael Roichman, Yair Glick, Noga Touitou, Haim Y. Cohen, Orly Yaron, Matan Y. Avivi, Liat Nahum, Robert A. Harris, Frank K. Huynh, Reuven Gil, Yariv Kanfi, Eyal Gottlieb, Shoshana Naiman, Batia Lerrer, Tirza Doniger
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4127-4143.e8 (2019)
Summary: The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling, known to regulate multiple metabolic pathways. SIRT6 binds PPARα a
Autor:
Frank K. Huynh, Kristofer S. Fritz, Colin T. Shearn, Nichole Reisdorph, Peter Harris, David J. Orlicky, Cole R. Michel, Richard Reisdorph, Mohammed A. Assiri, Laura Saba, Hadi R. Ali, Matthew D. Hirschey, Youngho Yun, John O. Marentette
Publikováno v:
Journal of Proteome Research. 18:1513-1531
Mitochondrial dysfunction is one of many key factors in the etiology of alcoholic liver disease (ALD). Lysine acetylation is known to regulate numerous mitochondrial metabolic pathways, and recent reports demonstrate that alcohol-induced protein acyl
Autor:
Zhihong Lin, Aeowynn J Coakley, Christopher B. Newgard, Jonathan E. Campbell, Thi-Tina N. Nguyen, Brett S. Peterson, Matthew D. Hirschey, Kristin A. Anderson, Samuel B. Stephens, Fiara M S Llaguno, Frank K. Huynh
Publikováno v:
Am J Physiol Endocrinol Metab
Sirtuins are a family of proteins that regulate biological processes such as cellular stress and aging by removing posttranslational modifications (PTMs). We recently identified several novel PTMs that can be removed by sirtuin 4 (SIRT4), which is fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95aacf44c0c40317ad3fb87492b0b6d
https://europepmc.org/articles/PMC7750516/
https://europepmc.org/articles/PMC7750516/
Publikováno v:
Journal of Inherited Metabolic Disease. 41:59-72
Several inherited metabolic disorders are associated with an accumulation of reactive acyl-CoA metabolites that can non-enzymatically react with lysine residues to modify proteins. While the role of acetylation is well-studied, the pathophysiological
Autor:
Timothy J. Kieffer, Eva Tudurí, Ali Asadi, Marjolaine Philit, James D. Johnson, Galina Soukhatcheva, Robert K. Baker, C. Bruce Verchere, Cara E. Ellis, Frank K. Huynh, Maria M. Glavas
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
The study of primary glucagon-secreting α-cells is hampered by their low abundance and scattered distribution in rodent pancreatic islets. We have designed a double-stranded adeno-associated virus containing a rat proglucagon promoter (700 bp) drivi
Autor:
Mohammad Mahdi Daoud, Ana Colaço, Christian A. Olsen, Saswati Chakladar, Peter Fristrup, Frank K. Huynh, Kristin A. Anderson, Donald S. Backos, Christian Beyschau Andersen, Matthew D. Hirschey, Jonas S. Laursen, Andreas Stahl Madsen
Publikováno v:
Journal of Biological Chemistry. 291:7128-7141
Protein lysine posttranslational modification by an increasing number of different acyl groups is becoming appreciated as a regulatory mechanism in cellular biology. Sirtuins are class III histone deacylases that use NAD(+)as a co-substrate during am
Publikováno v:
The FASEB Journal. 32
Autor:
Frank K. Huynh, Olga Ilkayeva, Matthew D. Hirschey, Richard A. Miller, Timothy M. Robinette, Igor M. Sokolov, Justin W. Nicholatos, Saurabh V.P. Tata, Sergiy Libert, Maxim Dokukin, Michael Platov, Michael A. Weinstein, Dmyro Volkov, Adam R. Boyko, Adam B. Francisco, Jennifer D. Yordy
Publikováno v:
SSRN Electronic Journal.
Among its many breeds, dogs exhibit exceptional variation in their rate of aging and average lifespan, which presents an opportunity to identify longevity-associated traits via comparative analysis. Using primary dermal fibroblasts, we investigated m