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Autor:
Mjt Reinders, Martijn H. Brugman, Adrian J. Thrasher, Gerard Wagemaker, Miranda R. M. Baert, Denise T. D. de Ridder, J J M van Dongen, Monique M.A. Verstegen, Frank Jakob Theodor Staal, Floor Weerkamp, Steven J. Howe, Karin Pike-Overzet
Publikováno v:
Leukemia, 21(4), 754-763. Nature Publishing Group
The occurrence of leukemia in a gene therapy trial for SCID-X1 has highlighted insertional mutagenesis as an adverse effect. Although retroviral integration near the T-cell acute lymphoblastic leukemia (T-ALL) oncogene LIM-only protein 2 (LMO2) appea