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of 19
pro vyhledávání: '"Frank J.S. Lee"'
Publikováno v:
Synapse (New York, N.Y.)REFERENCES. 76(3-4)
The retromer complex is an evolutionarily conserved protein complex involved in the endosomal recycling of various cargo proteins. It is ubiquitously expressed in all tissue and is found in both invertebrate as well as mammalian nervous systems, wher
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-10 (2020)
BMC Genetics
BMC Genetics
Background DNA methylation is an epigenetic modification that mainly repress expression of genes essential during embryogenesis and development. There are key ATPase-dependent enzymes that read or write DNA methylation to remodel chromatin and regula
Autor:
Mark P. Labrecque, Michael E. Cox, Timothy V. Beischlag, S. Khakshour, Edward J. Park, Hadi Esmaeilsabzali, Frank J.S. Lee
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Hypoxia modulates actin organization via multiple pathways. Analyzing the effect of hypoxia on the biophysical properties of cancer cells is beneficial for studying modulatory signalling pathways by quantifying cytoskeleton rearrangements. We have ch
Autor:
Frank J.S. Lee, Shazina S. Khan
Publikováno v:
Journal of Molecular Neuroscience. 53:10-21
Both the cannabinoid CB1 receptor (CB1) and dopamine D2 receptor (D2R) are G protein-coupled receptors that are linked to inhibitory Gαi/o protein, whereby activation of the receptor leads to the inhibition of cAMP production. Moreover, previous fin
Autor:
Hui Xu, Bo Gong, Ming Gao Zhao, Ming Ren, Yu Ze Shang, Hansen Wang, Min Zhuo, Hiroki Toyoda, Long Jun Wu, Fang Liu, Susan S. Kim, Frank J.S. Lee
Publikováno v:
Neuron. 59(4):634-647
The fragile X mental retardation protein (FMRP) is an RNA-binding protein that controls translational efficiency and regulates synaptic plasticity. Here, we report that FMRP is involved in dopamine (DA) modulation of synaptic potentiation. AMPA gluta
Publikováno v:
The EMBO Journal. 26:2127-2136
Altered synaptic dopamine levels have been implicated in several neurological/neuropsychiatric disorders, including drug addiction and schizophrenia. However, it is unclear what precipitates these changes in synaptic dopamine levels. One of the key p
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136641 (2015)
PLoS ONE
PLoS ONE
The regulation of the dopamine transporter (DAT) impacts extracellular dopamine levels after release from dopaminergic neurons. Furthermore, a variety of protein partners have been identified that can interact with and modulate DAT function. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a758feb56ef2e8c4f587244f200f7d5
http://summit.sfu.ca/item/16010
http://summit.sfu.ca/item/16010
Autor:
Nadege Chéry, Sheng Xue, Frank J.S. Lee, Lin Pei, Fang Liu, Hyman B. Niznik, Xian-Min Yu, Yushan Wang, Brian Vukusic, Yu Tian Wang
Publikováno v:
Cell. 111:219-230
Dopamine D1-like receptors, composed of D1 and D5 receptors, have been documented to modulate glutamate-mediated fast excitatory synaptic neurotransmission. Here, we report that dopamine D1 receptors modulate NMDA glutamate receptor-mediated function
Publikováno v:
Synapse. 71:e21963
Using an in vitro model of ischemic stroke we treated differentiated SH-SY5Y cells to oxygen-glucose deprivation (OGD) followed by a reperfusion period where normal growth conditions were restored. Cells undergoing OGD exhibited significant cell deat
Publikováno v:
The FASEB Journal. 15:916-926
Mutations in alpha-synuclein, a protein highly enriched in presynaptic terminals, have been implicated in the expression of familial forms of Parkinson's disease (PD) whereas native alpha-synuclein is a major component of intraneuronal inclusion bodi