Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Frank J. Vittimberga"'
Autor:
Rocco Ricciardi, Susan E. Donohue, Robin D. Kim, Frank J. Vittimberga, Saif Anwaruddin, William C. Meyers, Suzanne M. Wheeler, Steven H. Quarfordt, David P. Foley, Mark P. Callery
Publikováno v:
Journal of Surgical Research. 96:114-119
Early recognition of hepatic function during initial graft reperfusion is important in beginning hepatic support perfusions as well as in liver transplantation. We hypothesized that both hemodynamic and metabolic perfusion variables obtained immediat
Publikováno v:
Journal of Surgical Research. 90:39-44
Background. Genetic mutations found in pancreatic cancer (K- ras, p16, p53) lead to inappropriate cellular proliferation. Mitogens stimulate proliferation via the phosphatidylinositol 3-kinase (PI3K)- and/or the p44/42-mitogen-activated protein kinas
Publikováno v:
Surgery. 126:371-377
Background: Tumor necrosis factor (TNF-α)–induced apoptosis is limited by coactivation of nuclear factor kappa B (NF-kb)–dependent antiapoptotic genes. Nuclear translocation of NF-kB requires degradation of ubiquitinated phospho-IkB-a by the 26S
Publikováno v:
Journal of Surgical Research. 84:143-149
Introduction. Transcriptional activation of the TNF-α gene in LPS-stimulated macrophages is dependent upon nuclear factor kappa-B (NF-κB) activity. Salicylates may interfere with NF-κB activity through a MAPK (mitogen-activated protein kinase)-dep
Publikováno v:
Annals of Surgery. 227:326-334
OBJECTIVE: The authors review studies relating to the immune responses evoked by laparoscopic surgery. SUMMARY BACKGROUND DATA: Laparoscopic surgery has gained rapid acceptance based on clinical grounds. Patients benefit from faster recovery, decreas
Publikováno v:
Critical Reviews in Eukaryotic Gene Expression. 8:377-393
Adenocarcinoma of the pancreas carries a grave prognosis for affected patients. Certain oncogenes (K-ras and HER-2/neu) are mutated in a large proportion of these aggressive tumors. Adenocarcinoma of the pancreas has also been associated with loss of
Publikováno v:
Surgical endoscopy. 14(12)
Evidence tends to support a relative preservation of the systemic immune response with laparoscopy as compared with laparotomy. However, the role of hepatic macrophages, or Kupffer cells, in modulating this immune advantage is unknown. This study inv
Autor:
Frank J. Vittimberga, Mark P. Callery, Theodore P. McDade, Richard A. Perugini, Andrew J. Duffy
Publikováno v:
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 4(1)
The mutations most common in pancreatic cancer decrease the ability to control G1 to S cell cycle progression and cellular proliferation. In colorectal cancer cells, nonsteroidal anti-inflammatory drugs inhibit proliferation and induce cell cycle arr
Autor:
Mark P. Callery, Frank J. Vittimberga, Barbara F. Banner, Yun-Cai Cai, Xiaowen Xu, Zhong Jiang, Bruce A. Woda, Louis Savas
Publikováno v:
Virchows Archiv : an international journal of pathology. 435(2)
Activation of epidermal growth factor receptor (EGFR) is associated with cell growth and transformation. Both transforming growth factor-alpha (TGF-alpha) and epidermal growth factor bind to and activate EGFR. We studied the expression of TGF-alpha a
Autor:
Jamie MacPhee, Frank J. Vittimberga, Mark P. Callery, Rocco Ricciardi, Angela N. Traylor, Thomas J. McLaughlin, Steven H. Quarfordt, David P. Foley, Susan E. Donohue, William C. Meyers
Publikováno v:
Transplantation. 68(3)
BACKGROUND Hepatic support systems that provide detoxification without biliary secretion (i.e., isolated hepatocyte systems) are sufficient to improve encephalopathy and bridge patients to transplantation. However, biliary secretion may be critical w