Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Frank J. T. Staal"'
Autor:
Nataël Sorel, Francisco Díaz-Pascual, Boris Bessot, Hanem Sadek, Chloé Mollet, Myriam Chouteau, Marco Zahn, Irene Gil-Farina, Parisa Tajer, Marja van Eggermond, Dagmar Berghuis, Arjan C. Lankester, Isabelle André, Richard Gabriel, Marina Cavazzana, Kasrin Pike-Overzet, Frank J. T. Staal, Chantal Lagresle-Peyrou
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1495 (2024)
Recombinase-activating gene (RAG)-deficient SCID patients lack B and T lymphocytes due to the inability to rearrange immunoglobulin and T cell receptor genes. The two RAG genes act as a required dimer to initiate gene recombination. Gene therapy is a
Externí odkaz:
https://doaj.org/article/4a78380a81614b73972ca4a329e27f1f
Autor:
Nannan Guo, Na Li, Li Jia, Qinyue Jiang, Mette Schreurs, Vincent van Unen, Susana M. Chuva de Sousa Lopes, Alexandra A. Vloemans, Jeroen Eggermont, Boudewijn Lelieveldt, Frank J. T. Staal, Noel F. C. C. de Miranda, M. Fernanda Pascutti, Frits Koning
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The intestine is an important immunological organ in embryonic life, preparing the infant for the microbial colonization following birth. Here authors show that between gestational weeks 14 and 22, the human foetal intestine is first populated by mye
Externí odkaz:
https://doaj.org/article/bc204bc2c6094dffa261d580b254f052
Autor:
Leire Solis, Samya Van Coillie, James R. Bonham, Fabian Hauck, Lennart Hammarström, Frank J. T. Staal, Bruce Lim, Martine Pergent, Johan Prévot
Publikováno v:
International Journal of Neonatal Screening, Vol 10, Iss 2, p 30 (2024)
This article presents the report of the session on “Newborn Screening for Primary Immunodeficiencies—Now What?” organised during the International Primary Immunodeficiency Congress (IPIC) held in November 2023. This clinical conference was orga
Externí odkaz:
https://doaj.org/article/fa56b81f5cb84ed99bb72cf9a5e005c1
Autor:
Maria Carmina Castiello, Martina Di Verniere, Elena Draghici, Elena Fontana, Sara Penna, Lucia Sereni, Alessandra Zecchillo, Denise Minuta, Paolo Uva, Marco Zahn, Irene Gil-Farina, Andrea Annoni, Silvia Iaia, Lisa M. Ott de Bruin, Luigi D. Notarangelo, Karin Pike-Overzet, Frank J. T. Staal, Anna Villa, Valentina Capo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionRecombination activating genes (RAG) 1 and 2 defects are the most frequent form of severe combined immunodeficiency (SCID). Patients with residual RAG activity have a spectrum of clinical manifestations ranging from Omenn syndrome to dela
Externí odkaz:
https://doaj.org/article/a13d91e55f6747b49b59db07466d98d7
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The mature lymphocyte population of a healthy individual has the remarkable ability to recognise an immense variety of antigens. Instead of encoding a unique gene for each potential antigen receptor, evolution has used gene rearrangements, also known
Externí odkaz:
https://doaj.org/article/ecd357aefea54d2599733daca96dea52
Autor:
Martijn Cordes, Karin Pike-Overzet, Erik B. Van Den Akker, Frank J. T. Staal, Kirsten Canté-Barrett
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Traditionally, flow cytometry has been the preferred method to characterize immune cells at the single-cell level. Flow cytometry is used in immunology mostly to measure the expression of identifying markers on the cell surface, but—with good antib
Externí odkaz:
https://doaj.org/article/c3ff236601894bfa9f36f207e911dac6
Autor:
Mihaela Zlei, Igor A. Sidorov, Simone A. Joosten, Mirjam H. M. Heemskerk, Sebenzile K. Myeni, Cilia R. Pothast, Caroline S. de Brouwer, A. Linda Boomaars-van der Zanden, Krista E. van Meijgaarden, Shessy T. Morales, Els Wessels, Jacqueline J. Janse, Jelle J. Goeman, Christa M. Cobbaert, Aloys C. M. Kroes, Suzanne C. Cannegieter, Meta Roestenberg, Leonardus G. Visser, Marjolein Kikkert, Mariet C. W. Feltkamp, Sesmu M. Arbous, Frank J. T. Staal, Tom H. M. Ottenhoff, Jacques J. M. van Dongen, Anna H. E. Roukens, Jutte J. C. de Vries, in collaboration with BEAT-COVID, in collaboration with LUMC COVID
Publikováno v:
Cells, Vol 11, Iss 17, p 2743 (2022)
Virus-specific cellular and humoral responses are major determinants for protection from critical illness after SARS-CoV-2 infection. However, the magnitude of the contribution of each of the components to viral clearance remains unclear. Here, we st
Externí odkaz:
https://doaj.org/article/70065a3824ce4890ba8d4a1f3bff6993
Autor:
Peiman Shooshtarizadeh, Anne Helness, Charles Vadnais, Nelleke Brouwer, Hugues Beauchemin, Riyan Chen, Halil Bagci, Frank J. T. Staal, Jean-François Coté, Tarik Möröy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling t
Externí odkaz:
https://doaj.org/article/dc1d6a2a5faa46caa688da1feb30cd2a
Autor:
Jolanda J. D. de Roo, Amiet Chhatta, Laura Garcia-Perez, Brigitta A. E. Naber, Sandra A. Vloemans, Daniela C. F. Salvatori, Karin Pike-Overzet, Harald Mikkers, Frank J. T. Staal
Publikováno v:
Cells, Vol 11, Iss 17, p 2679 (2022)
The development of T lymphocytes in the thymus and their stem cell precursors in the bone marrow is controlled by Wnt signaling in strictly regulated, cell-type specific dosages. In this study, we investigated levels of canonical Wnt signaling during
Externí odkaz:
https://doaj.org/article/f6fbe9006a224665ace8e4225a694060
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/0a680cd61a77493899ce061dee5c9107