Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Frank J. Slack"'
Autor:
Eric Struth, Maryam Labaf, Vida Karimnia, Yiran Liu, Gwendolyn Cramer, Joanna B. Dahl, Frank J. Slack, Kourosh Zarringhalam, Jonathan P. Celli
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Interactions between tumor and stromal cells are well known to play prominent roles in progression of pancreatic ductal adenocarcinoma (PDAC). As knowledge of stromal crosstalk in PDAC has evolved, it has become clear that cancer associated
Externí odkaz:
https://doaj.org/article/9b02c2f9693f44e5a07a39320a2640fa
Autor:
Christos Miliotis, Yuling Ma, Xanthi-Lida Katopodi, Dimitra Karagkouni, Eleni Kanata, Kaia Mattioli, Nikolas Kalavros, Yered H. Pita-Juárez, Felipe Batalini, Varune R. Ramnarine, Shivani Nanda, Frank J. Slack, Ioannis S. Vlachos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The landscape of non-coding mutations in cancer progression and immune evasion is largely unexplored. Here, we identify transcrptome-wide somatic and germline 3′ untranslated region (3′-UTR) variants from 375 gastric cancer patients from
Externí odkaz:
https://doaj.org/article/7e900114ce37476b816c721095f77f00
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 136-139 (2023)
The Keystone Symposium ‘Small Regulatory RNAs: From Bench to Bedside’ was held in Santa Fe, New Mexico from May 1–4, 2022. The symposium was organized by Frank J. Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt, and brought together scienti
Externí odkaz:
https://doaj.org/article/bedea14fe23247d8aa50bf32d94633b4
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Severe COVID-19 leads to widespread transcriptomic changes in the human brain, mimicking diminished cognitive performance. As long noncoding RNAs (lncRNAs) play crucial roles in the regulation of gene expression, identification of the lncRNAs differe
Externí odkaz:
https://doaj.org/article/8e88a92ee8984811be2945ff6ba71bdb
Autor:
Vishal Kasina, Aniket Wahane, Chung-Hao Liu, Lin Yang, Mu-Ping Nieh, Frank J. Slack, Raman Bahal
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 271-283 (2023)
Many diseases, especially cancer, are caused by the abnormal expression of non-coding microRNAs (miRNAs), which regulate gene expression, leading to the development of miRNA-based therapeutics. Synthetic miRNA inhibitors have shown promising efficacy
Externí odkaz:
https://doaj.org/article/44603b949dd346f5bf4cfc4a46eb9487
Autor:
Jonathan D. Lee, Bridget L. Menasche, Maria Mavrikaki, Madison M. Uyemura, Su Min Hong, Nina Kozlova, Jin Wei, Mia M. Alfajaro, Renata B. Filler, Arne Müller, Tanvi Saxena, Ryan R. Posey, Priscilla Cheung, Taru Muranen, Yujing J. Heng, Joao A. Paulo, Craig B. Wilen, Frank J. Slack
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113478- (2023)
Summary: Coronavirus disease 2019 (COVID-19) remains a significant public health threat due to the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants to evade the immune system and cause breakthrough infections. Although
Externí odkaz:
https://doaj.org/article/fc5e40c8967549f19441624446c62419
Autor:
Neha Singh, Varune R. Ramnarine, Jin H. Song, Ritu Pandey, Sathish K. R. Padi, Mannan Nouri, Virginie Olive, Maxim Kobelev, Koichi Okumura, David McCarthy, Michelle M. Hanna, Piali Mukherjee, Belinda Sun, Benjamin R. Lee, J. Brandon Parker, Debabrata Chakravarti, Noel A. Warfel, Muhan Zhou, Jeremiah J. Bearss, Ewan A. Gibb, Mohammed Alshalalfa, R. Jefferey Karnes, Eric J. Small, Rahul Aggarwal, Felix Feng, Yuzhuo Wang, Ralph Buttyan, Amina Zoubeidi, Mark Rubin, Martin Gleave, Frank J. Slack, Elai Davicioni, Himisha Beltran, Colin Collins, Andrew S. Kraft
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Elevated expression of long noncoding RNA H19 is seen in clinical samples of neuroendocrine prostate cancer (PCa). Here the authors show H19 promotes plasticity from luminal to neuroendocrine by epigenetic reprogramming.
Externí odkaz:
https://doaj.org/article/fe3ffb322dcb47a8b750da286a3e5ab2
Autor:
Julia Ramírez-Moya, Christos Miliotis, Allison R. Baker, Richard I. Gregory, Frank J. Slack, Pilar Santisteban
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-20 (2021)
Abstract Background Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is associated with several cancers. We recently showed that A-to-I editing
Externí odkaz:
https://doaj.org/article/3ca24ab8383d42e88c0f6bf7dd321fc5
Autor:
Latika Matai, Frank J. Slack
Publikováno v:
Non-Coding RNA, Vol 9, Iss 2, p 26 (2023)
Aging is associated with the accumulation of damaged and misfolded proteins through a decline in the protein homeostasis (proteostasis) machinery, leading to various age-associated protein misfolding diseases such as Huntington’s or Parkinson’s.
Externí odkaz:
https://doaj.org/article/fd9a8a57a0b14ce5a8d3aa34cdbdbca6
Autor:
Adrienne Vancura, Alejandro H. Gutierrez, Thorben Hennig, Carlos Pulido-Quetglas, Frank J. Slack, Rory Johnson, Simon Haefliger
Publikováno v:
Non-Coding RNA, Vol 8, Iss 6, p 82 (2022)
Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between y
Externí odkaz:
https://doaj.org/article/add39e3887884a82aced286ad7e35274