Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Frank J. Simutis"'
Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron
Autor:
Heidrun Ellinger-Ziegelbauer, Connie L Chen, Jean-François Léonard, Michael R. Tackett, James Eric McDuffie, Elnaz Atabakhsh, Ernie Harpur, Rounak Nassirpour, Brian N. Chorley, Laurence O. Whiteley, Gleta Carswell, Alison H. Harrill, Jean-Charles Gautier, Frank J. Simutis
Publikováno v:
Toxicological Sciences
Drug-induced kidney injury (DIKI) is a major concern in both drug development and clinical practice. There is an unmet need for biomarkers of glomerular damage and more distal renal injury in the loop of Henle and the collecting duct (CD). A cross-la
Autor:
Victor D. Martinez, James Eric McDuffie, Jean-Charles Gautier, Frank J. Simutis, Conor Rafferty, Alison H. Harrill, Roland Froetschl, David Jackson, Lauren Peel, Rachel J. Church, Philippe Couttet, Heidrun Ellinger-Ziegelbauer, Brian N. Chorley, Elnaz Atabakhsh, Tatiana Sharapova, Peter S.T. Yuen, Graeme Doran, Parimal Pande
Publikováno v:
Crit Rev Toxicol
MicroRNAs (miRNAs) are small non-coding RNA that regulate the expression of messenger RNA and are implicated in almost all cellular processes. Importantly, miRNAs are can be released extracellularly and are stable in these matrices where they may ser
Publikováno v:
Seminars in Nephrology. 39:120-131
The kidney's role as a major route of metabolism and clearance of xenobiotics and its ability to concentrate the glomerular filtrate make it particularly vulnerable to drug-induced toxicity. Improving kidney safety is an active area of research and t
Autor:
Frank J. Simutis, Joshua T. Gamse, Michael J. Graziano, Helen G. Haggerty, Rashade Haynes, Wendy J. Freebern, Mary Pazian, James Crona, Roderick T. Bunch
Publikováno v:
Toxicology and applied pharmacology. 409
The OX40 receptor plays a crucial co-stimulatory role in T effector cell survival, expansion, cytokine production, and cytotoxicity to tumor cells; therefore, OX40 agonists are being evaluated as anti-cancer immunotherapies, especially in combination
Publikováno v:
Toxicological Sciences. 163:525-542
The toxicity of avagacestat, a sulfonamide-based gamma (γ)-secretase inhibitor that was in development as a treatment for Alzheimer's disease, was evaluated in a comprehensive nonclinical toxicology program that included 6-month and 1-year repeat-do
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology.
Avagacestat, a gamma (γ)-secretase inhibitor that was in development for treatment of Alzheimer’s disease, produced ovarian granulosa-thecal cell tumors in rats and dogs and a glomerulopathy with profound proteinuria in female rats. This report de
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5
Autor:
Amy Easton, Jeffrey M. Brown, Valerie J. Whiterock, Yanling Huang, Gail K. Mattson, Kelli M. Jones, Michele Matchett, Arun K. Senapati, Andrew P. Degnan, Frank J. Simutis, Yu-Wen Li, Lawrence B. Snyder, Alda Fernandes, Digavalli V. Sivarao, Anand Balakrishnan, Umesh Hanumegowda, Kenneth S. Santone, Eric Shields, Regina Miller, Joanne J. Bronson, Ryan Westphal, Michael Gulianello, John E. Macor, Hong Huang, Fukang Yang
Positive allosteric modulators (PAMs) of the metabotropic glutamate receptor subtype 5 (mGluR5) are of interest due to their potential therapeutic utility in schizophrenia and other cognitive disorders. Herein we describe the discovery and optimizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0406345b8ecda64a2e9a0876f7702b99
https://europepmc.org/articles/PMC4789665/
https://europepmc.org/articles/PMC4789665/
Autor:
Anthony M. Fletcher, John C. Kozlosky, Courtni Newsome, Jean G Sathish, Frank J. Simutis, Michael J. Graziano, Annette Capozzi, Daniel Szatkowski, Karen Price, John J. Engelhardt, Lila Ramaiah, Austin Thekkumthala, Helen G. Haggerty, Jennifer Wheeler, James Crona, Bojing Wang, Wendy J. Freebern, Rima Srour, Todd Bunch
Publikováno v:
Molecular Cancer Therapeutics. 17:LB-B33
Ipilimumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), an inhibitory receptor expressed on activated effector T cells and regulatory T cells (Treg), that inhibits the bin
Publikováno v:
Journal of Histotechnology. 32:198-201
Adherence of formalin-fixed tissues to glass microslides for both automated and manual immunohistochemistry procedures can be difficult because of the application of multiple reagents and the limited use of tissue bonding reagents. The use of positiv
Publikováno v:
Immunology Letters. 107:76-79
Summary Ruminants infected with Mycobacterium avium subspecies paratuberculosis consistently develop a multibacillary form of disease that is centered on the ileum. Mechanisms responsible for failure of macrophage function during multibacillary disea