Výsledky vyhledávání - "Frank J. McAtee"

Oligodendrocytes Are a Major Target of the Toxicity of Spongiogenic Murine Retroviruses

Autor: Lindsay E. Parrie, J L Portis, A.C. Clase, David Ron, Frank J. McAtee, David W. Dorward, Cynthia Favara, Derek E. Dimcheff

Publikováno v: The American Journal of Pathology. 169:1026-1038

The neurovirulent retroviruses FrCasE and Moloney MLV-ts1 cause noninflammatory spongiform neurodegeneration in mice, manifested clinically by progressive spasticity and paralysis. Neurons have been thought to be the primary target of toxicity of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a33368d608138d7833eda245717fb7
https://doi.org/10.2353/ajpath.2006.051357

Zobrazit plný text záznamu

N-Terminal Cleavage Fragment of Glycosylated Gag Is Incorporated into Murine Oncornavirus Particles

Autor: Frank J. McAtee, Stanley F. Hayes, John L. Portis, Ryuichi Fujisawa, Cynthia Favara

Publikováno v: Journal of Virology. 75:11239-11243

Glycosylated Gag (Glycogag) is a transmembrane protein encoded by murine and feline oncornaviruses. While the protein is dispensible for virus replication, Glycogag-null mutants of a neurovirulent murine oncornavirus are slow to spread in vivo and ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c46c9aed2439203449d9daab33b501
https://doi.org/10.1128/jvi.75.22.11239-11243.2001

Zobrazit plný text záznamu

The Neuroinvasiveness of a Murine Retrovirus Is Influenced by a Dileucine-Containing Sequence in the Cytoplasmic Tail of Glycosylated Gag

Autor: Frank J. McAtee, Kathy Wehrly, Ryuichi Fujisawa, John L. Portis

Publikováno v: Journal of Virology. 72:5619-5625

Neonatal inoculation of CasBrE, an ecotropic murine retrovirus originally isolated from wild mice (16, 17), causes a neurologic disease manifested by noninflammatory spongiform degeneration primarily in areas of the central nervous system involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb710974f916f2fd2f5301adc043f04
https://doi.org/10.1128/jvi.72.7.5619-5625.1998

Zobrazit plný text záznamu

Characterization of glycosylated Gag expressed by a neurovirulent murine leukemia virus: identification of differences in processing in vitro and in vivo

Autor: John L. Portis, Frank J. McAtee, Ryuichi Fujisawa, Joseph H. Zirbel

Publikováno v: Journal of Virology. 71:5355-5360

The neuroinvasiveness of a chimeric murine retrovirus, CasFrKP (KP), is dependent on the expression of glycosylated Gag (gp85gag). This viral protein is the product of alternate translation initiation 88 codons upstream of and in frame with the initi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d4c67994ece95426151c36da3e6d3e
https://doi.org/10.1128/jvi.71.7.5355-5360.1997

Zobrazit plný text záznamu

The GlycosylatedgagProtein of MuLV Is a Determinant of Neuroinvasiveness: Analysis of Second Site Revertants of a Mutant MuLV Lacking Expression of This Protein

Autor: John L. Portis, Frank J. McAtee, Ryuichi Fujisawa

Publikováno v: Virology. 226:384-392

Neuroinvasiveness is a property of all neurovirulent murine retroviruses, although the factors which facilitate infection of the CNS are not understood. We previously showed that mutant MuLV which lack expression of an accessory protein, glycosylated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10d8fdff84374fc49f7e0ffe71bfa84
https://doi.org/10.1006/viro.1996.0666

Zobrazit plný text záznamu

Protective efficacy of nonneutralizing monoclonal antibodies in acute infection with murine leukemia virus

Autor: R Ireland, Ryuichi Fujisawa, Seth H. Pincus, Frank J. McAtee, R Cole, John L. Portis

Publikováno v: Journal of Virology. 69:7152-7158

We have used an experimental retrovirus infection to study the roles played by different antibodies in resistance to both infection and disease. A molecularly cloned chimeric murine leukemia virus was used to induce acute lethal neurological disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8030e630c06c67f389df185e1c78417
https://doi.org/10.1128/jvi.69.11.7152-7158.1995

Zobrazit plný text záznamu

Identification of a sequence in the unique 5' open reading frame of the gene encoding glycosylated Gag which influences the incubation period of neurodegenerative disease induced by a murine retrovirus

Autor: Gerald J. Spangrude, John L. Portis, Frank J. McAtee

Publikováno v: Journal of Virology. 68:3879-3887

Neonatal inoculation of the wild-mouse ecotropic retrovirus CasBrE (clone 15-1) causes a noninflammatory spongiform neurodegenerative disease with an incubation period of > or = 6 months. Introduction of sequences from Friend murine leukemia virus (c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32b5951dae32ef2d42ddf7df7dd1c0d
https://doi.org/10.1128/jvi.68.6.3879-3887.1994

Zobrazit plný text záznamu

Murine retrovirus-induced spongiform encephalopathy: Productive infection of microglia and cerebellar neurons in accelerated CNS disease

Autor: William P. Lynch, Frank J. McAtee, John L. Portis, Stephanie Czub, Stanley F. Hayes

Publikováno v: Neuron. 7:365-379

We have examined the pathological lesions and sites of infection in mice inoculated with a highly neurovirulent recombinant wild mouse ecotropic retrovirus (FrCasE). The spongiform lesions appeared initially as swollen postsynaptic neuronal processes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6313358ac053d5091a6dcdceafa1e4c
https://doi.org/10.1016/0896-6273(91)90289-c

Zobrazit plný text záznamu

Endoplasmic reticulum (ER) stress induced by a neurovirulent mouse retrovirus is associated with prolonged BiP binding and retention of a viral protein in the ER

Autor: Derek E. Dimcheff, Mark A. Faasse, J L Portis, Frank J. McAtee

Publikováno v: The Journal of biological chemistry. 279(32)

Some murine retroviruses cause a spongiform neurodegenerative disease exhibiting pathology resembling that observed in transmissible spongiform encephalopathies. The neurovirulence of these "spongiogenic retroviruses" is determined by the sequence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0004b4ddbae2cff06538b88c13e22ca2
https://pubmed.ncbi.nlm.nih.gov/15178688

Zobrazit plný text záznamu

Increased expression of MIP-1 alpha and MIP-1 beta mRNAs in the brain correlates spatially and temporally with the spongiform neurodegeneration induced by a murine oncornavirus

Autor: Cynthia Favara, John L. Portis, Frank J. McAtee, Srdjan Askovic

Publikováno v: Journal of virology. 75(6)

The chimeric murine oncornavirus FrCasEcauses a rapidly progressive paralytic disease associated with spongiform neurodegeneration throughout the neuroaxis. Neurovirulence is determined by the sequence of the viral envelope gene and by the capacity o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f37c8cc36b7a8a99587bf9d26532071
https://pubmed.ncbi.nlm.nih.gov/11222690

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání