Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Frank J. Gunn Moore"'
Autor:
Darren J. X. Chow, Erik P. Schartner, Stella Corsetti, Avinash Upadhya, Josephine Morizet, Frank J. Gunn-Moore, Kylie R. Dunning, Kishan Dholakia
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Embryo quality assessment by optical imaging is increasing in popularity. Among available optical techniques, light sheet microscopy has emerged as a superior alternative to confocal microscopy due to its geometry, enabling faster image acqu
Externí odkaz:
https://doaj.org/article/6af357eccedb4582a952e8a8d2b1b6bc
Publikováno v:
Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-17 (2020)
Abstract Background Lipid dysregulation is associated with several key characteristics of Alzheimer’s disease (AD), including amyloid-β and tau neuropathology, neurodegeneration, glucose hypometabolism, as well as synaptic and mitochondrial dysfun
Externí odkaz:
https://doaj.org/article/933b20ad671746a58c50281520036f2b
Autor:
Nils M. Kronenberg, Andrew Tilston-Lunel, Frances E. Thompson, Doris Chen, Wanjia Yu, Kishan Dholakia, Malte C. Gather, Frank J. Gunn-Moore
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Willin/FRMD6 is part of a family of proteins with a 4.1 ezrin-radixin-moesin (FERM) domain. It has been identified as an upstream activator of the Hippo pathway and, when aberrant in its expression, is associated with human diseases and disorders. Ev
Externí odkaz:
https://doaj.org/article/810fe848f8e84347b5596fd3f2b2ab06
Autor:
Wardiya Afshar Saber, Federico M. Gasparoli, Marjet G. Dirks, Frank J. Gunn-Moore, Maciej Antkowiak
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
We introduce a novel all-optical assay for functional studies of biological neural networks in vitro. We created a novel optogenetic construct named OptoCaMP which is a combination of a channelrhodopsin variant (CheRiff) and a red genetically encoded
Externí odkaz:
https://doaj.org/article/45fd1af6ad98483dae731641c45bc4b7
Autor:
Laura Aitken, Ondrej Benek, Brogan E. McKelvie, Rebecca E. Hughes, Lukas Hroch, Monika Schmidt, Louise L. Major, Lucie Vinklarova, Kamil Kuca, Terry K. Smith, Kamil Musilek, Frank J. Gunn-Moore
Publikováno v:
Molecules, Vol 24, Iss 15, p 2757 (2019)
It has long been established that mitochondrial dysfunction in Alzheimer’s disease (AD) patients can trigger pathological changes in cell metabolism by altering metabolic enzymes such as the mitochondrial 17β-hydroxysteroid dehydrogenase type 10 (
Externí odkaz:
https://doaj.org/article/c039f8abf9114eae9e6a20208c4c6e80
Autor:
Monika Schmidt, Frank J. Gunn-Moore, Kamil Musilek, Kamil Kuca, Ondrej Benek, Lucie Vinklarova
Publikováno v:
Journal of Neurochemistry. 155:231-249
17β-hydroxysteroid dehydrogenase (17β-HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b64145a214535a64368880159d7b5b7
https://doi.org/10.1111/jnc.15027
https://doi.org/10.1111/jnc.15027
Autor:
Karina Vitanova, Gayle H. Doherty, Rona R. Ramsay, Matthew J. Buchan, Ying Cheng, Laura Aitken, Frank J. Gunn-Moore
Publikováno v:
Journal of Neurochemistry. 155:191-206
Authors would like to acknowledge ARUK for supporting this research. YC is Chinese Scholarship recipient. The University of St Andrews is a charity registered in Scotland: No SC013532 Mitochondrial dysfunction has a recognised role in the progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae53fcbfef891931f123660ff771ea6
https://doi.org/10.1111/jnc.15003
https://doi.org/10.1111/jnc.15003
Autor:
Kishan Dholakia, Frank J. Gunn-Moore, Sumi Bez, Jonathan Nylk, Matthew J. Broadhead, Fei Zhu, Lauren Arcinas, Gareth B. Miles, Seth G. N. Grant, Calum Bonthron, Frances Elizabeth Goff
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Functionally distinct synapses exhibit diverse and complex organisation at molecular and nanoscale levels. Synaptic diversity may be dependent on developmental stage, anatomical locus and the neural circuit within which synapses reside. Furthermore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d99c11b6a8e1d219558c7294422e3c6
http://europepmc.org/articles/PMC8613274
http://europepmc.org/articles/PMC8613274
Publikováno v:
Cells, Vol 10, Iss 3024, p 3024 (2021)
Cells
Cells
The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ac0bcf7bfac2c0df9f22dee4f17104
https://www.mdpi.com/2073-4409/10/11/3024
https://www.mdpi.com/2073-4409/10/11/3024
Autor:
Yanghua Wang MD, PhD, Adam Gersten MD, Susana Moleirinho PhD, Frank J. Gunn-Moore PhD, Paul A. Reynolds PhD, Michael B. Prystowsky MD, PhD
Publikováno v:
Academic Pathology, Vol 2 (2015)
We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with p
Externí odkaz:
https://doaj.org/article/421a4475da414f96a69af2cace74089c