Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Frank J. Burczynski"'
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2238-2247 (2015)
Over four decades have passed since liver fatty acid binding protein (FABP)1 was first isolated. There are few protein families for which most of the complete tertiary structures, binding properties, and tissue occurrences are described in such detai
Externí odkaz:
https://doaj.org/article/98c2b2dfd0994e15aa8601dfc2ebb9df
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 21 (2018)
Purpose: To develop and characterize vitamin A (VA)-coupled liposomes for the targeted delivery of BMP4-siRNA to hepatic stellate cells (HSC). VA was selected to increase the uptake by HSC based on their function in the storage of VA. Methods: DOTAP/
Externí odkaz:
https://doaj.org/article/b236eb8dcf6242f290f738d8387d6209
Autor:
Samaa Alrushaid, Neal M. Davies, Judy E. Anderson, Tyson Le, Jaime A. Yáñez, Zaid H. Maayah, Ayman O.S. El-Kadi, Ousama Rachid, Casey L. Sayre, Raimar Löbenberg, Frank J. Burczynski
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 21, Iss 1s (2018)
PURPOSE: MyoNovin is a novel skeletal muscle-regenerating compound developed through synthesis of two nitro groups onto a guaifenesin backbone to deliver nitric oxide to skeletal muscle with a potential to treat muscle atrophy. The purpose of this st
Externí odkaz:
https://doaj.org/article/e895d65cc6e748e6b35ead553dc5471e
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 12, Pp 2445-2454 (2009)
Hepatocytes expressing liver fatty acid binding protein (L-FABP) are known to be more resistant to oxidative stress than those devoid of this protein. The mechanism for the observed antioxidant activity is not known. We examined the antioxidant mecha
Externí odkaz:
https://doaj.org/article/9f656e359dbf4246a9789c1c0dba7905
Autor:
Samaa Alrushaid, Casey L. Sayre, Jaime A. Yáñez, M. Laird Forrest, Sanjeewa N. Senadheera, Frank J. Burczynski, Raimar Löbenberg, Neal M. Davies
Publikováno v:
Pharmaceutics, Vol 9, Iss 3, p 35 (2017)
Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox’s bioavailability and tolerabi
Externí odkaz:
https://doaj.org/article/3090fddc4f504d7c9d83bde50c24e222
Publikováno v:
Recent Patents on Drug Delivery & Formulation. 12:238-251
Skeletal muscle is a highly-specialized tissue that is capable of contractile function and able to withstand and adapt to daily mechanical and physiological stress. Musculoskeletal disorders, including muscular dystrophies, result in chronic pain and
Background: Intra- and extra- hepatic cholangiocarcinoma (I-CCA and E-CCA respectively) exhibit different growth features that contribute to different clinical outcomes. Cancer stem cells (CSCs) influence tumor growth and thereby, may be responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc98cabd541e8620f6d9dbc3861fa1a2
https://doi.org/10.21203/rs.3.rs-214257/v1
https://doi.org/10.21203/rs.3.rs-214257/v1
Autor:
Tyson Le, Karen Ethans, Howard Intrater, Marianna Pozdirca, Samaa Alrushaid, Ting Zhou, Frank J. Burczynski, Jiming Kong, Michael Namaka, Tina Khorshid Ahmad
Publikováno v:
Biochemical and biophysical research communications. 516(2)
There is a growing surge of investigative research involving the beneficial use of cannabinoids as novel interventional alternatives for multiple sclerosis (MS) and associated neuropathic pain (NPP). Using an experimental autoimmune encephalomyelitis
Autor:
Ryan Lillico, Neal M. Davies, Tyson Le, Yuewen Gong, Michael S. Roberts, Ted M. Lakowski, Frank J. Burczynski
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 21, Iss 1s (2018)
PURPOSE: Liver fatty acid binding protein (FABP1) is a cytoplasmic polypeptide that transports substrates throughout the cytosol and functions as an antioxidant. A common polymorphic variant, FABP1 T94A has a minor allele frequency of 26-38%, 8.3±1.
Publikováno v:
Journal of Pharmaceutical Sciences. 105:497-508
A critical component in the development of physiologically based pharmacokinetic-pharmacodynamic (PBPK/PD) models for estimating target organ dosimetry in pharmacology and toxicology studies is the understanding of the uptake kinetics and accumulatio