Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Frank J. Beurskens"'
Autor:
Sjors P. A. van der Lans, Bart W. Bardoel, Maartje Ruyken, Carla J. C. de Haas, Stan Baijens, Remy M. Muts, Lisette M. Scheepmaker, Piet C. Aerts, Marije F. L. van ’t Wout, Johannes Preiner, Renoud J. Marijnissen, Janine Schuurman, Frank J. Beurskens, Priscilla F. Kerkman, Suzan H. M. Rooijakkers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Antibody-dependent complement activation plays a key role in the natural human immune response to infections. Currently, the understanding of which antibody-antigen combinations drive a potent complement response on bacteria is limited. Here
Externí odkaz:
https://doaj.org/article/a558f4acbc8844f0b4f524c388b29ef9
Autor:
Lisanne de Vor, Coco R. Beudeker, Anne Flier, Lisette M. Scheepmaker, Piet C. Aerts, Daniel C. Vijlbrief, Mireille N. Bekker, Frank J. Beurskens, Kok P. M. van Kessel, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Michiel van der Flier
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Central line associated bloodstream infections (CLABSI) with Staphylococcus epidermidis are a major cause of morbidity in neonates, who have an increased risk of infection because of their immature immune system. As especially preterm neonates suffer
Externí odkaz:
https://doaj.org/article/c668e35acaa743bdbfdce9f1042fa215
Autor:
Elizabeth M. Parzych, Sunita Gulati, Bo Zheng, Mamadou A. Bah, Sarah T. C. Elliott, Jacqueline D. Chu, Nancy Nowak, George W. Reed, Frank J. Beurskens, Janine Schuurman, Peter A. Rice, David B. Weiner, Sanjay Ram
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Neisseria gonorrhoeae
Externí odkaz:
https://doaj.org/article/f8a963212313460cb9282d3601ffc0c2
Autor:
Mario Losen, Aran F. Labrijn, Vivianne H. van Kranen-Mastenbroek, Maarten L. Janmaat, Krista G. Haanstra, Frank J. Beurskens, Tom Vink, Margreet Jonker, Bert A. ‘t Hart, Marina Mané-Damas, Peter C. Molenaar, Pilar Martinez-Martinez, Eline van der Esch, Janine Schuurman, Marc H. de Baets, Paul W. H. I. Parren
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Autoantibodies against ion channels are the cause of numerous neurologic autoimmune disorders. Frequently, such pathogenic autoantibodies have a restricted epitope-specificity. In such cases, competing antibody formats devoid of pathogenic e
Externí odkaz:
https://doaj.org/article/24f5b6bf021946909f7c67a223ec548b
Autor:
Simone C. Oostindie, Hilma J. van der Horst, Margaret A. Lindorfer, Erika M. Cook, Jillian C. Tupitza, Clive S. Zent, Richard Burack, Karl R. VanDerMeid, Kristin Strumane, Martine E. D. Chamuleau, Tuna Mutis, Rob N. de Jong, Janine Schuurman, Esther C. W. Breij, Frank J. Beurskens, Paul W. H. I. Parren, Ronald P. Taylor
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
CD20 monoclonal antibody therapies have significantly improved the outlook for patients with B-cell malignancies. However, many patients acquire resistance, demonstrating the need for new and improved drugs. We previously demonstrated that the natura
Externí odkaz:
https://doaj.org/article/8951ab20ead14f0a871191432d4962ce
Autor:
Fabio Da Roit, Patrick J. Engelberts, Ronald P. Taylor, Esther C.W. Breij, Giuseppe Gritti, Alessandro Rambaldi, Martino Introna, Paul W.H.I. Parren, Frank J. Beurskens, Josée Golay
Publikováno v:
Haematologica, Vol 100, Iss 1 (2015)
The novel Bruton tyrosine kinase inhibitor ibrutinib and phosphatidyl-4-5-biphosphate 3-kinase-δ inhibitor idelalisib are promising drugs for the treatment of chronic lymphocytic leukemia and B-cell non-Hodgkin lymphoma, either alone or in combinati
Externí odkaz:
https://doaj.org/article/1c94da3a61174fd1bdb1a8cfcd711ad4
Autor:
Peter Boross, J.H. Marco Jansen, Simone de Haij, Frank J. Beurskens, Cees E. van der Poel, Lisette Bevaart, Maaike Nederend, Josée Golay, Jan G.J. van de Winkel, Paul W.H.I. Parren, Jeanette H.W. Leusen
Publikováno v:
Haematologica, Vol 96, Iss 12 (2011)
Background CD20 monoclonal antibodies are widely used in clinical practice. Antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity and direct cell death have been suggested to be important effector functions for CD20 antibodies.
Externí odkaz:
https://doaj.org/article/a659aed66c1947d2853f66ffdd576053
Autor:
Simone C. Oostindie, Derek A. Rinaldi, Gijs G. Zom, Michael J. Wester, Desiree Paulet, Kusai Al-Tamimi, Els van der Meijden, Jennifer R. Scheick, Tessa Wilpshaar, Bart de Jong, Marloes Hoff-van den Broek, Rachel M. Grattan, Janita J. Oosterhoff, Julie Vignau, Sandra Verploegen, Peter Boross, Frank J. Beurskens, Diane S. Lidke, Janine Schuurman, Rob N. de Jong
Publikováno v:
Nature Biotechnology. 40:1509-1519
The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect®, an approach to enhance the functional selectiv
Autor:
Esther C.W. Breij, Rob N. de Jong, Paul W.H.I. Parren, Janine Schuurman, Ulf Forssmann, Andreas Lingnau, Richard G. Hibbert, Naomi Hoevenaars, Bart de Jong, Thessa Kroes, Boris S. Vuillermoz, Claudine Vermot-Desroches, Antonio Ortiz Buijsse, Frank J. Beurskens, Kristin Strumane, Marije B. Overdijk
Supplemental Tables Supplemental Figures Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc0742629adc9c9f5ee0bce476596b4
https://doi.org/10.1158/1535-7163.22520991.v1
https://doi.org/10.1158/1535-7163.22520991.v1
Autor:
Esther C.W. Breij, Rob N. de Jong, Paul W.H.I. Parren, Janine Schuurman, Ulf Forssmann, Andreas Lingnau, Richard G. Hibbert, Naomi Hoevenaars, Bart de Jong, Thessa Kroes, Boris S. Vuillermoz, Claudine Vermot-Desroches, Antonio Ortiz Buijsse, Frank J. Beurskens, Kristin Strumane, Marije B. Overdijk
Higher-order death receptor 5 (DR5) clustering can induce tumor cell death; however, therapeutic compounds targeting DR5 have achieved limited clinical efficacy. We describe HexaBody-DR5/DR5, an equimolar mixture of two DR5-specific IgG1 antibodies w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f853ed6f8830a1d4904eeb661710e2
https://doi.org/10.1158/1535-7163.c.6542862.v1
https://doi.org/10.1158/1535-7163.c.6542862.v1