Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Frank J Schoenen"'
Publikováno v:
Frontiers in Oncology, Vol 6 (2016)
Cancer cells are addicted to numerous non-oncogenic traits that enable them to thrive. Proteotoxic stress is one such non-oncogenic trait that is experienced by all tumor cells, owing to increased genomic abnormalities and the resulting synthesis and
Externí odkaz:
https://doaj.org/article/7d876951f5ef49a0838204e7704598f3
Autor:
Shigeto Nishikawa, Atsushi Kaida, Alejandro Parrales, Atul Ranjan, Mohamed Alalem, Hongyi Ren, Frank J. Schoenen, David K. Johnson, Tomoo Iwakuma
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract Cancers are frequently addicted to oncogenic missense mutant p53 (mutp53). DNAJA1, a member of heat shock protein 40 (HSP40), also known as J-domain proteins (JDPs), plays a crucial role in the stabilization and oncogenic activity of misfold
Externí odkaz:
https://doaj.org/article/32dc6a9804484bb98536de5316509fc1
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Pancreatic cancer is a devastating disease with a dismal prognosis and poor treatment outcomes. Searching for new agents for pancreatic cancer treatment is of great significance. We previously identified a novel activity of compound C150 to inhibit p
Externí odkaz:
https://doaj.org/article/d5e370f443d7474b992b7416b07bf444
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Pancreatic cancer cell epithelial-to-mesenchymal transition (EMT) is an important contributor to cell invasion and tumor progression. Therefore, targeting EMT may be beneficial for pancreatic cancer treatment. The aim of the present study was to repo
Externí odkaz:
https://doaj.org/article/9b879f6d38104a6bbce3b648f7625ba8
Autor:
Kevin J. Frankowski, Samarjit Patnaik, Chen Wang, Noel Southall, Dipannita Dutta, Soumitta De, Dandan Li, Christopher Dextras, Yi-Han Lin, Marthe Bryant-Connah, Danielle Davis, Feijun Wang, Leah M. Wachsmuth, Pranav Shah, Jordan Williams, Md Kabir, Edward Zhu, Bolormaa Baljinnyam, Amy Wang, Xin Xu, John Norton, Marc Ferrer, Steve Titus, Anton Simeonov, Wei Zheng, Lesley A. Mathews Griner, Ajit Jadhav, Jeffrey Aubé, Mark J. Henderson, Udo Rudloff, Frank J. Schoenen, Sui Huang, Juan J. Marugan
Publikováno v:
J Med Chem
The perinucleolar compartment (PNC) is a dynamic subnuclear body found at the periphery of the nucleolus. The PNC is enriched with RNA transcripts and RNA-binding proteins, reflecting different states of genome organization. PNC prevalence positively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cb0efba8b4e86b0d112961571f1a63
https://doi.org/10.1021/acs.jmedchem.2c00204
https://doi.org/10.1021/acs.jmedchem.2c00204
Autor:
Benjamin K. Gibbs, Justin T. Douglas, Rebecca J. Wates, Peter R. McDonald, Amy M. Whitaker, Cornelius N. Ndi, Harsh B. Pathak, Laurie A. Harned, Sarah A. Neuenswander, Melinda A. Broward, Bret D. Freudenthal, Anuradha Roy, Frank J. Schoenen, Andrew K. Godwin
Publikováno v:
Cancer Research. 83:5334-5334
Most cases of epithelial ovarian cancer (EOC) exhibit extensive molecular heterogeneity, presenting challenges in developing targeted therapies. Despite extensive efforts and incremental successes in developing targeted drugs and immunotherapies for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee924373012b8f43292295e1ee8e23e3
https://doi.org/10.1158/1538-7445.am2023-5334
https://doi.org/10.1158/1538-7445.am2023-5334
Autor:
Xinbo Luo, Bart Lutterbach, Priya Pancholi, Yeon Sook Choi, Xiao Liu, Phillip Munson, Saqib Faisal, David A. Whipple, Robert A. Smith, Warren S. Weiner, David K. Johnson, Myriam Boukhali, Nicole S. Persky, Matthew G. Rees, Shunsuke Kitajima, David Barbie, Anuradha Roy, Michael Baltezor, Lian Rajewski, William McGuinness, John Haslam, Ananthan Sadagopan, Charles H. Yoon, Cory M. Johannessen, Christine G. Lian, Jason L. Hornick, Srinivas R. Viswanathan, David Liu, Vicki Nienaber, Wilhelm Haas, Frank J. Schoenen, David E. Fisher, Rizwan Haq
Publikováno v:
Cancer Research. 83:1706-1706
The transcription factor NRF2 is a master regulator of cellular responses to oxidative stress, contributing to the pathogenesis of autoimmunity, metabolic disorders, and neurodegeneration. Somatic alterations in the NRF2 pathway also contribute to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e04d0b7c12a4af9fee06850f1e9b16
https://doi.org/10.1158/1538-7445.am2023-1706
https://doi.org/10.1158/1538-7445.am2023-1706
Autor:
Frank J. Schoenen, Ben Gold, Véronique Dartois, David T Zhang, Carl Nathan, Patrick Porubsky, Stacey L. McDonald, Matthew D. Zimmerman, Quyen Nguyen, Hsin-Pin Ho-Liang, Andrew J. Perkowski, Cameron W Pharr, Robert A. Smith, Jeffrey Aubé
Publikováno v:
The Journal of antibiotics
A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aad17ff3ca703c679b48baf0783aa94
http://europepmc.org/articles/PMC7255492
http://europepmc.org/articles/PMC7255492
Autor:
Siddhartha Ganguly, Shrikant Anant, Rekha Rao, Neil Dunavin, Amar Kumar, Roy A. Jensen, Anusha Vallurupalli, Dharmalingam Subramaniam, Joseph P. McGuirk, Frank J. Schoenen, Pratikkumar Vekaria
Publikováno v:
Leukemia. 33:1675-1686
p97 is an ATPase that works in concert with histone deacetylase 6 (HDAC6), to facilitate the degradation of misfolded proteins by autophagosomes. p97 has also been implicated in DNA repair and maintaining genomic stability. In this study, we determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21043cebf13452ea65729d20e41f24f6
https://doi.org/10.1038/s41375-018-0355-y
https://doi.org/10.1038/s41375-018-0355-y
Autor:
Katharine R. Trenholme, Donald L. Gardiner, Patrick R. Griffin, Peter Chase, Louis Scampavia, Timothy P. Spicer, Peter Hodder, Sudeshna Roy, Frank J. Schoenen
Publikováno v:
SLAS Discovery. 24:38-46
Malaria remains a major cause of morbidity and mortality worldwide with ~3.3 billion people at risk of contracting malaria and an estimated 450,000 deaths each year. While tools to reduce the infection prevalence to low levels are currently under dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0d8d36828ca385237e97203ebc2210
https://doi.org/10.1177/2472555218796410
https://doi.org/10.1177/2472555218796410