Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Frank J Poelwijk"'
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 6, p e1004771 (2016)
Externí odkaz:
https://doaj.org/article/ebb8ab669cb74ef6b1236c1aff7cc5a4
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003580 (2013)
The epistatic interactions that underlie evolutionary constraint have mainly been studied for constant external conditions. However, environmental changes may modulate epistasis and hence affect genetic constraints. Here we investigate genetic constr
Externí odkaz:
https://doaj.org/article/8d7d259eb0ee4c5abc5aba7b35ca6661
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 5, p e58 (2006)
Ample evidence has accumulated for the evolutionary importance of duplication events. However, little is known about the ensuing step-by-step divergence process and the selective conditions that allow it to progress. Here we present a computational s
Externí odkaz:
https://doaj.org/article/f17208d6c9fa4c37bc824151c316dc89
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Epistasis underlies the complexity of genotype-phenotype maps. Here, the authors analyze 8,192 mutants that link two phenotypically distinct variants of the Entacmaea quadricolor fluorescent protein, and show the existence, but also the sparsity, of
Externí odkaz:
https://doaj.org/article/fdb7e3cd099544148ee4ec803288d902
Autor:
Frank J. Poelwijk, Manjunatha Kogenaru, Marjon G. J. de Vos, Sander J. Tans, Liedewij Laan, Philippe Nghe, Enzo Kingma
Publikováno v:
Annual Review of Biophysics, 49:49
The limits of evolution have long fascinated biologists. However, the causes of evolutionary constraint have remained elusive due to a poor mechanistic understanding of studied phenotypes. Recently, a range of innovative approaches have leveraged mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132638b0f98fd80634137bf225129e1f
https://doi.org/10.1146/annurev-biophys-070317-032939
https://doi.org/10.1146/annurev-biophys-070317-032939
Autor:
Thomas A Hopf, John B Ingraham, Frank J Poelwijk, Charlotta P I Schärfe, Michael Springer, Chris Sander, Debora S Marks
Publikováno v:
Nature Biotechnology. 35:128-135
Many high-throughput experimental technologies have been developed to assess the effects of large numbers of mutations (variation) on phenotypes. However, designing functional assays for these methods is challenging, and systematic testing of all com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d333fe58dd9abe0eedb8483a1bcbb56
https://doi.org/10.1038/nbt.3769
https://doi.org/10.1038/nbt.3769
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Understanding the pattern of epistasis—the non-independence of mutations—is critical for relating genotype and phenotype. However, the combinatorial complexity of potential epistatic interactions has severely limited the analysis of this problem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da177d5de24c0ce4c0953bd40cfb33ca
https://doi.org/10.1038/s41467-019-12130-8
https://doi.org/10.1038/s41467-019-12130-8
Autor:
Debora S. Marks, Nicholas P. Gauthier, Richard R. Stein, Sachdev S. Sidhu, Michael A Stiffler, Kelly P Brock, Joan Teyra, Frank J. Poelwijk, Adam J. Riesselman, Chris Sander
Publikováno v:
Cell systems. 10(1)
Summary Natural evolution encodes rich information about the structure and function of biomolecules in the genetic record. Previously, statistical analysis of co-variation patterns in natural protein families has enabled the accurate computation of 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3666d2d66407cf02c7b0e44f087ef6
https://pubmed.ncbi.nlm.nih.gov/31838147
https://pubmed.ncbi.nlm.nih.gov/31838147
Gene regulation networks allow organisms to adapt to diverse environmental niches. However, the constraints underlying the evolution of regulatory phenotypes remain ill-defined both theoretically and experimentally. Here, we show that the concept of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15822cbe3efad24b4a22c818f41eecb
https://doi.org/10.1101/722520
https://doi.org/10.1101/722520
Autor:
Chris Sander, Nicholas P. Gauthier, Joan Teyra, Kelly P Brock, Michael A Stiffler, Debora S. Marks, Frank J. Poelwijk, Richard R. Stein, Sachdev S. Sidhu
Natural evolution encodes rich information about the structure and function of biomolecules in the genetic record. Previously, statistical analysis of co-variation patterns in natural protein families has enabled the accurate computation of 3D struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d491b5facd8e146ce328ab05afc66b
https://doi.org/10.1101/667790
https://doi.org/10.1101/667790