Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Frank J Giordano"'
Autor:
Steven D Mason, Richard A Howlett, Matthew J Kim, I Mark Olfert, Michael C Hogan, Wayne McNulty, Reed P Hickey, Peter D Wagner, C Ronald Kahn, Frank J Giordano, Randall S Johnson
Publikováno v:
PLoS Biology, Vol 2, Iss 10, p e288 (2004)
The physiological flux of oxygen is extreme in exercising skeletal muscle. Hypoxia is thus a critical parameter in muscle function, influencing production of ATP, utilization of energy-producing substrates, and manufacture of exhaustion-inducing meta
Externí odkaz:
https://doaj.org/article/32adb9c80a7d42adabde5991d4f218bf
Publikováno v:
EBioMedicine, Vol 9, Iss C, Pp 27-28 (2016)
Externí odkaz:
https://doaj.org/article/a37bafeee99f44dbbe87bcdac8f6f646
Autor:
Kana Mizuno, Sravan K. Perla, Jae Sung Yi, Anton M. Bennett, Alexander A. Vinks, Frank J. Giordano, Yan Huang
Publikováno v:
Cardiovascular drugs and therapy. 36(4)
Purpose Noonan syndrome with multiple lentigines (NSML) is an autosomal dominant disorder presenting with hypertrophic cardiomyopathy (HCM). Up to 85% of NSML cases are caused by mutations in the PTPN11 gene that encodes for the Src homology 2 (SH2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da76961d6d6fbbeba23eb9453e148f31
https://pubmed.ncbi.nlm.nih.gov/33689087
https://pubmed.ncbi.nlm.nih.gov/33689087
Publikováno v:
Circulation. 142
Introduction: Cardiac remodeling occurs in response to pathological stimuli including chronic pressure overload, subsequently leading to heart failure. Despite considerable research efforts, the molecular mechanisms responsible for heart failure have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bfa0bd47c44bbbc48551d53cf51382a
https://doi.org/10.1161/circ.142.suppl_3.16205
https://doi.org/10.1161/circ.142.suppl_3.16205
Publikováno v:
Genesis (New York, N.Y. : 2000)REFERENCES. 58(3-4)
Oxygen (O2 ) homeostasis is essential to the metazoan life. O2 -sensing or hypoxia-regulated molecular pathways are intimately involved in a wide range of critical cellular functions and cell survival from embryogenesis to adulthood. In this report,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716a33dee11a198b307277edec7bc23b
https://pubmed.ncbi.nlm.nih.gov/31872977
https://pubmed.ncbi.nlm.nih.gov/31872977
Autor:
Dinggang Liu, Li Lei, Frank J. Giordano, Jacob Cleman, Yan Huang, Weidong Jiang, Carlos Fernández-Hernando, William C. Sessa, Annarita Di Lorenzo, Matthew Desir
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36:442-445
Objective— We hypothesized that the hypoxia-inducible factor (HIF) 1α in vascular smooth muscle contributes to the development of atherosclerosis, and links intravascular pressure to this process. Approach and Results— Transverse aortic constric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbbbc2cd211e09b2dadbd0524c9bc0b
https://doi.org/10.1161/atvbaha.115.306861
https://doi.org/10.1161/atvbaha.115.306861
Autor:
Frank J. Giordano, Hideru Obinata, Timothy Hla, Sylvain Galvani, Yi Zhang, Annarita Di Lorenzo, Milankumar Kothiya, Xian-Cheng Jiang, Mariarosaria Bucci, Anna Cantalupo
Publikováno v:
Nature Medicine. 21:1028-1037
Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce431661c0853b747284138a1570d50
https://doi.org/10.1038/nm.3934
https://doi.org/10.1038/nm.3934
Autor:
Michael J. Jurczak, Patty J. Lee, Frank J. Giordano, Serpil C. Erzurum, Yi Zhang, Iva Dostanic, Kerry S. Russell, Maria Haslip, Yan Huang, Praveen Mannam
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:1166-1178
Objectives— Pulmonary hypertension (PH) is a process of lung vascular remodeling, which can lead to right heart dysfunction and significant morbidity. The underlying mechanisms leading to PH are not well understood, and therapies are limited. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d40f121da2581db77dae81bb526e13
https://doi.org/10.1161/atvbaha.114.304865
https://doi.org/10.1161/atvbaha.114.304865
Autor:
George Tellides, Ford Hinojosa-Kirschenbaum, Frank J. Giordano, Qunhua Huang, Haifeng Zhang, Huanjiao Jenny Zhou, Wang Min, Yan Huang, Grant R. Budas, Peidong Fan, Luiz Belardinelli, Lina Yao
Publikováno v:
Circulation. 131:1082-1097
Background— Thioredoxin 2 (Trx2) is a key mitochondrial protein that regulates cellular redox and survival by suppressing mitochondrial reactive oxygen species generation and by inhibiting apoptosis stress kinase-1 (ASK1)–dependent apoptotic sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d32349042380fc4688f10e52ff9697
https://doi.org/10.1161/circulationaha.114.012725
https://doi.org/10.1161/circulationaha.114.012725