Výsledky vyhledávání - "Frank J Castora"

Akademický článek

Age-associated metabolic and morphologic changes in mitochondria of individual mouse and hamster oocytes.

Autor: Fatma Simsek-Duran, Fang Li, Wentia Ford, R James Swanson, Howard W Jones, Frank J Castora

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64955 (2013)

BACKGROUND: In human oocytes, as in other mammalian ova, there is a significant variation in the pregnancy potential, with approximately 20% of oocyte-sperm meetings resulting in pregnancies. This frequency of successful fertilization decreases as th

Externí odkaz: https://doaj.org/article/04e59cc23c184d89876fde7dd3b2772a

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Incorporating Mitochondrial Gene Expression Changes Within a Testable Mathematical Model for Alzheimer’s Disease: Stress Response Modulation Predicts Potential Therapeutic Targets

Autor: Morgan G, Shelton, Kimberly A, Kerns, Frank J, Castora, Randolph A, Coleman

Publikováno v: Journal of Alzheimer's Disease. 90:109-117

Background: Alzheimer’s disease is a specific form of dementia characterized by the aggregation of amyloid-β plaques and tau tangles. New research has found that the formation of these aggregates occurs after dysregulation of cellular respiration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2218e215cbf99533748a9790d5aeb8
https://doi.org/10.3233/jad-220163

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Expression Changes in Mitochondrial Genes Affecting Mitochondrial Morphology, Transmembrane Potential, Fragmentation, Amyloidosis, and Neuronal Cell Death Found in Brains of Alzheimer’s Disease Patients

Autor: Frank J, Castora, Kimberly A, Kerns, Haley K, Pflanzer, Naomi L, Hitefield, Blake, Gershon, Jason, Shugoll, Morgan, Shelton, Randolph A, Coleman

Publikováno v: Journal of Alzheimer's Disease. 90:119-137

Background: Alzheimer’s disease (AD) is a neurological disease that has both a genetic and non-genetic origin. Mitochondrial dysfunction is a critical component in the pathogenesis of AD as deficits in oxidative capacity and energy production have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed2d671bc59b8a582cba7af2e4a2064
https://doi.org/10.3233/jad-220161

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Gel Electrophoresis, Southern and Northern Analysis

Autor: James J. Greene, Frank J. Castora

Publikováno v: Recombinant DNA Principles and Methodologies ISBN: 9781003067658
Recombinant DNA Principles and Methodologies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a93e7d88d926e74e3590b39f1a972f1e
https://doi.org/10.1201/9781003067658-7

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Enzymology of Recombinant DNA

Autor: Frank J. Castora

Publikováno v: Recombinant DNA Principles and Methodologies ISBN: 9781003067658
Recombinant DNA Principles and Methodologies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86d669aeae4be4fca91f46f2fce77dea
https://doi.org/10.1201/9781003067658-3

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The T9861C Mutation in the mtDNA-Encoded Cytochrome C Oxidase Subunit III Gene Occurs in High Frequency but with Unequal Distribution in the Alzheimer’s Disease Brain

Autor: Blake Gershon, Fatma Simsek-Duran, Kimberly A. Kerns, Frank J. Castora, Barbara Conyers, Robert Campbell

Publikováno v: Journal of Alzheimer's Disease. 72:257-269

Mitochondrial dysfunction is recognized as a critical component in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Deficits in oxidative capacity and, specifically, cytochrome c oxidase (CO) activity have been repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a120bff4c14de19ebf7af55eb6a131
https://doi.org/10.3233/jad-190176

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Mitochondrial function and abnormalities implicated in the pathogenesis of ASD

Autor: Frank J. Castora

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 92:83-108

Mitochondria are the powerhouse that generate over 90% of the ATP produced in cells. In addition to its role in energy production, the mitochondrion also plays a major role in carbohydrate, fatty acid, amino acid and nucleotide metabolism, programmed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beade49607f3e7e38920e7286dc685b4
https://doi.org/10.1016/j.pnpbp.2018.12.015

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