Výsledky vyhledávání - "Frank I. Carroll"

Design, synthesis and biological evaluation of a bi-specific vaccine against α-pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats

Autor: Anita H. Lewin, Frank I. Carroll, Eric C. Peterson, Samantha J. McClenahan, Melinda G. Gunnell, Samuel M. Owens, Pamela Lamb, Chad M. Kormos, Michael D. Hambuchen

Publikováno v: Vaccine

α-PVP (α-pyrrolidinovalerophenone) and MDPV (3,4-methylenedioxypyrovalerone) are potent abused stimulants that are members of the synthetic cathinone class of drugs. Although these drugs are taken with recreational intent, high doses can lead to un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8263efc82d9ecdf86159523bc655831c
https://doi.org/10.1016/j.vaccine.2019.10.008

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Formulation and Characterization of Conjugate Vaccines to Reduce Opioid Use Disorders Suitable for Pharmaceutical Manufacturing and Clinical Evaluation

Autor: Carla Hassler, Paul R. Pentel, Marco Pravetoni, Federico Baruffaldi, Frank I. Carroll, Michael D. Raleigh, Scott P. Runyon, S. J. King, S. Winston, Angela K. Birnbaum, Michaela J. Roslawski

Publikováno v: Mol Pharm

This study focused on formulating conjugate vaccines targeting oxycodone and heroin for technology transfer, good manufacturing practice (GMP), and clinical evaluation. Lead vaccines used the highly immunogenic carrier protein keyhole limpet hemocyan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca15cf948cde855080b502b2c7f708d1
https://pubmed.ncbi.nlm.nih.gov/31018096

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Simple Radiometric Method for Accurately Quantitating Epitope Densities of Hapten–Protein Conjugates with Sulfhydryl Linkages

Autor: Melinda G. Gunnell, Bruce E. Blough, Hambuchen, Jackson O. Lay, Cowell Jl, Rachel Tawney, Eric C. Peterson, Frank I. Carroll, Samuel M. Owens

Publikováno v: Bioconjugate Chemistry

Control of small molecule hapten epitope densities on antigenic carrier proteins is essential for development and testing of optimal conditions for vaccines. Yet, accurate determination of epitope density can be extremely difficult to accomplish, esp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49066829d2672e7c3add9c6a0dca9373
https://doi.org/10.1021/bc500456z

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Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse

Autor: Sandra D. Comer, Samantha J. Peterson, Federico Baruffaldi, Marco Pravetoni, Scott P. Runyon, Megan Laudenbach, Michael D. Raleigh, S. Winston, Paul R. Pentel, Frank I. Carroll, Tiffany L. Langston, Hernán A. Navarro

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0184876 (2017)
PLoS ONE

Among vaccines aimed at treating substance use disorders, those targeting opioids present several unique medication development challenges. 1) Opioid overdose is a common complication of abuse, so it is desirable for an opioid vaccine to block the to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2d2e6aa1f5ca0f3ceb5830d1e0ae15
http://europepmc.org/articles/PMC5711015?pdf=render

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In vivopharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model

Autor: M. I. Damaj, S.S. Negus, Frank I. Carroll, Kelen Freitas

Publikováno v: British Journal of Pharmacology. 169:567-579

Background and Purpose The α7 nicotinic ACh receptor subtype is abundantly expressed in the CNS and in the periphery. Recent evidence suggests that α7 nicotinic ACh receptor (nAChR) subtypes, which can be activated by an endogenous cholinergic tone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e3e05958ea90acffdc48c7e93a4d57a
https://doi.org/10.1111/j.1476-5381.2012.02226.x

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In silico design of novel probes for the atypical opioid receptor MRGPRX2

Autor: Hiroshi Nagase, Xi Ping Huang, Jian Jin, Jing Liu, Bryan L. Roth, John D. McCorvy, Frank I. Carroll, Tao Che, Katherine Lansu, Joel Karpiak, Wesley K. Kroeze, Brian K. Shoichet

Publikováno v: Nature chemical biology, vol 13, iss 5
Nature chemical biology

The primate-exclusive MRGPRX2 G protein-coupled receptor (GPCR) has been suggested to modulate pain and itch. Despite putative peptide and small molecule MRGPRX2 agonists, selective nanomolar potency probes have not yet been reported. To identify a M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fd429a91c6ef348464e3de0b5bc187
https://pubmed.ncbi.nlm.nih.gov/28417990

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Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys

Autor: Jeffrey S. Stehouwer, Heather L. Kimmel, Ronald J. Voll, Leonard L. Howell, John R. Votaw, Mark M. Goodman, Frank I. Carroll, Jiyoung Mun, Jonathon A. Nye

Publikováno v: Synapse. 66:501-508

Several classes of drugs bind to the dopamine transporter (DAT) with high affinity, but some are weaker positive reinforcers than cocaine, suggesting that affinity for and occupancy of the DAT is not the only determinant of a drug's reinforcing effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1578c4c8f45f7b4e7287af15a06afc
https://doi.org/10.1002/syn.21536

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Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities

Autor: Scott P. Runyon, Daniel E. Keyler, Ramakrishna R. Pidaparthi, Frank I. Carroll, Paul R. Pentel, Marco Pravetoni, C. A. Earley, Michael P. Murtaugh

Publikováno v: Biochemical Pharmacology. 83:543-550

Nicotine conjugate vaccine efficacy is limited by the concentration of nicotine-specific antibodies that can be reliably generated in serum. Previous studies suggest that the concurrent use of 2 structurally distinct nicotine immunogens in rats can g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8809ba06482c8584bfd48a0e59da19aa
https://doi.org/10.1016/j.bcp.2011.11.004

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1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists

Autor: Juan Pablo Cueva, Frank I. Carroll, Scott P. Runyon, James B. Thomas, Hernán A. Navarro, S. W. Mascarella

Publikováno v: ACS Medicinal Chemistry Letters. 1:365-369

This report describes the discovery that 1-substituted 4-(3-hydroxyphenyl)piperazines are pure opioid receptor antagonists. Compounds in this new series include N-phenylpropyl (3S)-3-methyl-4-(3-hydroxyphenyl)piperazine and (3R)-3-methyl-4-(3-hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2d93f88e1b6bb2c6ee58f87289878b
https://doi.org/10.1021/ml100126b

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The frequency of early-activated hapten-specific B cell subsets predicts the efficacy of vaccines for nicotine dependence

Autor: Megan Laudenbach, A.M. Tucker, Scott P. Runyon, Frank I. Carroll, Marco Pravetoni

Publikováno v: Vaccine. 33(46)

Therapeutic vaccines for nicotine addiction show pre-clinical efficacy. Yet, clinical evaluation of the first-generation nicotine vaccines did not meet expectations because only a subset of immunized subjects achieved effective serum antibody levels.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c104272b4ab1c02ef539de72645e79
https://pubmed.ncbi.nlm.nih.gov/26409811

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