Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Frank Hollinger"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3142-3146
Over activation of the PI3K/Akt/mTOR pathway is found in most cancer tumor types. Controlled regulation of this pathway using PI3K inhibitors can provide therapeutic significance in cancer treatment. Herein, we report the synthesis and evaluation of
Autor:
John M. Staatz, Frank Hollinger
Publikováno v:
West African Papers.
Fueled by a burgeoning population, urbanisation and income growth, West African food demand is rapidly transforming, with striking increases in total quantities demanded, growing preference for convenience, diversification of diets towards more peris
Autor:
Gary A. Flynn, Duyan Nguyen, Xiaomei Chai, Brandon A. Campbell, Marina Bukhtiyarova, Enrique Luis Michelotti, Eric B. Springman, Rupa Shetty, Variketta Namboodiri, Frank Hollinger, Katrina Northrop, Ted T. Fujimoto, Martha Jean Kelly, Michael Karpusas, Kristofer K. Moffett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5274-5279
Two new classes of diphenylether inhibitors of p38alpha MAP kinase are described. Both chemical classes are based on a common diphenylether core that is identified by simulated fragment annealing as one of the most favored chemotypes within a promine
Autor:
Lalwani Tarik, Patricia C. Weber, Paul Kirschmeier, Mark E. Snow, Ming Liu, Amin A. Nomeir, Linda James, Viyyoor M. Girijavallabhan, William T. Windsor, Robert Patton, Aki Cynthia J, Corey Strickland, Frank Hollinger, Doll Ronald J, Chao Jianping, Taveras Arthur G
Publikováno v:
Journal of Medicinal Chemistry. 45:3854-3864
The 10-bromobenzocycloheptapyridyl farnesyl transferase inhibitor (FTI) Sch-66336 (1) is currently under clinical evaluation for the treatment of human cancers. During structure-activity relationship development leading to 1, 10-bromobenzocycloheptap
Autor:
Guowei Zhou, Joan E. Brown, Melissa A.B. Tice, Nicholas J. Murgolo, Robert D. McQuade, Lisa A. Taylor, Joseph A. Kozlowski, Frank Hollinger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:785-788
An analog (SCH55112) of pirenzepine was prepared in which the N4 piperazyl nitrogen was replaced with carbon. This structrual change abolished the 55-fold m1/m2 selectivity of pirenzepine due to specific loss of m1 affinity. Mutagenesis mapping and m
Autor:
Milind Sagar, Frank Hollinger, Dinesh Mahajan, Bakul K. Dutta, Somdutta Sen, Reena Arora, Amal Ray Mahapatra, Sundeep Dugar, Ravinder Goel, Bilash Kulia, Amit Sharma
Publikováno v:
Cancer Research. 74:4515-4515
Background The discovery and development of inhibitors for the PI3K/AKT/mTOR signaling pathway is an attractive area of research due to its association with several oncogenic malignancies. This signaling pathway controls cellular growth as well as su