Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Frank Hilberg"'
Autor:
Niranjan Awasthi, Margaret A. Schwarz, Quinn Kaurich, Changhua Zhang, Frank Hilberg, Roderich E. Schwarz
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundGastric adenocarcinoma (GAC) is the fourth leading cause of cancer death worldwide. Systemic chemotherapy is a preferred treatment option for advanced and recurrent GAC, but response rates and survival prolongation remain limited. Tumor ang
Externí odkaz:
https://doaj.org/article/db0e706c33da4750a0dcdcee05569eb0
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-16 (2019)
Abstract Background Triple negative breast cancer (TNBC) is an aggressive malignancy with poor prognosis, in part because of the current lack of any approved molecularly targeted therapy. We evaluated various combinations of three different drugs: ni
Externí odkaz:
https://doaj.org/article/03b6d244b7c24be2ba561f6b2a274258
Autor:
Miriam Marqués, Sonia Corral, María Sánchez-Díaz, Natalia del Pozo, Jaime Martínez de Villarreal, Norbert Schweifer, Ivana Zagorac, Frank Hilberg, Francisco X. Real
Publikováno v:
Molecular Cancer Therapeutics. 22:616-629
Bladder cancer is a highly prevalent tumor, requiring the urgent development of novel therapies, especially for locally advanced and metastatic disease. Nintedanib is a potent antifibrotic angio-kinase inhibitor, which has shown clinical efficacy in
Autor:
Irmgard Hofmann, Anke Baum, Marco H. Hofmann, Francesca Trapani, Claudia Reichel-Voda, Diane Ehrensperger, Martin Aichinger, Florian Ebner, Nicole Budano, Norbert Schweifer, Martina Sykora, Erik Depla, Joachim Boucneau, Andreas Gschwind, Norbert Kraut, Frank Hilberg, Klaus-Peter Künkele
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 384:331-342
Autor:
Francisco X. Real, Frank Hilberg, Ivana Zagorac, Norbert Schweifer, Jaime Martínez de Villarreal, Natalia del Pozo, María Sánchez-Díaz, Sonia Corral, Miriam Marqués
Supplementary Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9653b288fd2721e48f3854aaf48c98eb
https://doi.org/10.1158/1535-7163.22758713
https://doi.org/10.1158/1535-7163.22758713
Autor:
Francisco X. Real, Frank Hilberg, Ivana Zagorac, Norbert Schweifer, Jaime Martínez de Villarreal, Natalia del Pozo, María Sánchez-Díaz, Sonia Corral, Miriam Marqués
Bladder cancer is a highly prevalent tumor, requiring the urgent development of novel therapies, especially for locally advanced and metastatic disease. Nintedanib is a potent antifibrotic angio-kinase inhibitor, which has shown clinical efficacy in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b7c3d1b382ed261e6488176e8fb279
https://doi.org/10.1158/1535-7163.c.6611318.v2
https://doi.org/10.1158/1535-7163.c.6611318.v2
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
Supplementary Material and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820b42e67f47200c9c178cedb99c7c5a
https://doi.org/10.1158/1535-7163.22520580.v1
https://doi.org/10.1158/1535-7163.22520580.v1
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
IHC for cleaved caspase-8 and cleaved caspase-3 24h after the second administration of BI 905711 in GP2d xenograft tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334db19e87c0561dd5ecdc1dc054e314
https://doi.org/10.1158/1535-7163.22520589
https://doi.org/10.1158/1535-7163.22520589
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
S1: Evaluation of CDH17 and TRAILR2 IHC staining in hepatic metastases of colorectal cancer -S2:BI 905711 kinetic and steady-state measurements -S3: CDH17 and TRAILR2 mean fluorescence intensity, antibody binding capacity and BI 905711 / TAS266' minP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b6cd5ccfd8bf8bdf5d258d7c9e5b48
https://doi.org/10.1158/1535-7163.22520577.v1
https://doi.org/10.1158/1535-7163.22520577.v1
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
Activation of TRAILR2 has emerged as an important therapeutic concept in cancer treatment. TRAILR2 agonistic molecules have only had limited clinical success, to date, due either to lack of efficacy or hepatotoxicity. BI 905711 is a novel tetravalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643c72c3613f080a868d2bc5298534ff
https://doi.org/10.1158/1535-7163.c.6542688.v1
https://doi.org/10.1158/1535-7163.c.6542688.v1