Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Frank Hertelendy"'
Autor:
Frank Hertelendy, Tamas Zakar
Publikováno v:
Current Pharmaceutical Design. 10:2499-2517
Regulation of myometrial functions during gestation, labor and birth are in the forefront of research in reproductive sciences. The complexity of the problem is reflected by our scant understanding of the intimate cellular and molecular events underl
Publikováno v:
Journal of the Society for Gynecologic Investigation. 9:215-219
To evaluate the effect of interferon γ (IFNγ) on interleukin-1β (IL-1) and tumor necrosis factor-α (TNFα)-promoted prostaglandin E2 (PGE2) production and to investigate the interaction of IFNγ and IL-1 on cyclooxygenase-2 (COX-2) expression, as
Publikováno v:
American Journal of Obstetrics and Gynecology. 181:42-49
Objective: The objective of our study was to test the hypothesis that oxytocin promotes prostaglandin production by up-regulating cyclooxygenase-2 via activation of mitogen-activated protein kinase cascade in human myometrial cells. Study Design: Con
Publikováno v:
The Journal of Maternal-Fetal Medicine. 7:222-226
Bacterial products are thought to induce labor by stimulating the production of pro-inflammatory cytokines and prostaglandins in gestational tissues, leading to the onset of preterm parturition. Progesterone withdrawal is a prerequisite of parturitio
Autor:
Herbert M. Todd, Vijaya L. Dundoo, William R. Gerber, Joseph J. Baldassare, Carrie A. Cwiak, Frank Hertelendy
Publikováno v:
The Journal of Maternal-Fetal Medicine. 5:161-167
The objective of this study was to characterize interleukin-1, -6, and -8 (IL-1-, IL-6-, and IL-8)-induced prostacyclin (PGI2 as 6-keto PGF1α) and prostaglandin E2 (PGE2) production in primary cultures of human myometrial cells. Prostaglandins (PGs)
Publikováno v:
Hypertension in Pregnancy. 14:287-300
Objectives: To characterize the activity and subcellular distribution of nitric oxide synthase (NOS) in primordial human placenta.Methods: Enzyme activity was assayed in chorion frondosum homoge-nate and subcellular fractions by measuring the convers
Publikováno v:
American Journal of Obstetrics and Gynecology. 170:1458-1466
Our purpose was to test the hypothesis that chronic inhibition of nitric oxide synthesis in pregnant rats can produce a preeclampsia-like syndrome.Pregnant rats were instrumented on day 14 of gestation (parturition day 21 to 22) and infused continuou
Publikováno v:
American Journal of Obstetrics and Gynecology. 169:825-829
Objective: Our aim was to evaluate the effects of the cytokines interleukin-1 and tumor necrosis factor on arachidonic acid release in human myometrial cells. Study design : Primary monolayer cultures of human myometrial cells prelabeled with tritiat
Publikováno v:
Biology of Reproduction. 46:698-704
Both cAMP and Ca2+ play important roles in the steroidogenic action of LH in hen granulosa cells. However, the interaction of these intracellular messengers is not fully understood. In the present study we used two calcium ionophores (ionomycin and A
Publikováno v:
General and Comparative Endocrinology. 85:335-340
When freshly dispersed granulosa cells from the largest preovulatory follicle were incubated in the presence of very low density (VLDL), low density (LDL), or high density (HDL) lipoproteins isolated from sera of laying hens, production of both basal