Výsledky vyhledávání - "Frank H Ebetino"

Akademický článek

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

Autor: Marcia A Munoz, Emma K Fletcher, Oliver P Skinner, Julie Jurczyluk, Esther Kristianto, Mark P Hodson, Shuting Sun, Frank H Ebetino, David R Croucher, Philip M Hansbro, Jacqueline R Center, Michael J Rogers

Publikováno v: eLife, Vol 10 (2021)

Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to r

Externí odkaz: https://doaj.org/article/efd2366c282f45e0a4b6b5d87db2968d

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Akademický článek

Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

Autor: Abigail A Coffman, Jelena Basta‐Pljakic, Rosa M Guerra, Frank H Ebetino, Mark W Lundy, Robert J Majeska, Mitchell B Schaffler

Publikováno v: JBMR Plus, Vol 5, Iss 7, Pp n/a-n/a (2021)

Externí odkaz: https://doaj.org/article/39b83b895613419fbd0d9763b0efaee3

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Akademický článek

A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

Autor: Abigail A Coffman, Jelena Basta‐Pljakic, Rosa M Guerra, Frank H Ebetino, Mark W Lundy, Robert J Majeska, Mitchell B Schaffler

Publikováno v: JBMR Plus, Vol 5, Iss 4, Pp n/a-n/a (2021)

ABSTRACT Bisphosphonates (BPs) are a mainstay of osteoporosis treatment; however, concerns about bone health based on oversuppression of remodeling remain. Long‐term bone remodeling suppression adversely affects bone material properties with microd

Externí odkaz: https://doaj.org/article/7379c21f04d841a7a77d926f4a2a7532

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Akademický článek

Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects

Autor: Zhenqiang Yao, Akram Ayoub, Venkatesan Srinivasan, Jun Wu, Churou Tang, Rong Duan, Aleksa Milosavljevic, Lianping Xing, Frank H. Ebetino, Alison J. Frontier, Brendan F. Boyce

Publikováno v: Bone Research, Vol 12, Iss 1, Pp 1-11 (2024)

Abstract Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone formation, while the anabolic agent, teriparatide, does not inhibit bone resorption, and thus they have limited efficacy in

Externí odkaz: https://doaj.org/article/9342ddf34d9e437d96b8b870a032df6e

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Akademický článek

Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis

Autor: Youliang Ren, Jason Weeks, Thomas Xue, Joshua Rainbolt, Karen L. de Mesy Bentley, Ye Shu, Yuting Liu, Elysia Masters, Philip Cherian, Charles E. McKenna, Jeffrey Neighbors, Frank H. Ebetino, Edward M. Schwarz, Shuting Sun, Chao Xie

Publikováno v: Bone Research, Vol 11, Iss 1, Pp 1-13 (2023)

Abstract Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achiev

Externí odkaz: https://doaj.org/article/96b573a5a803436d94a93195b6f70cb2

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Akademický článek

Bisphosphonate use in the horse: what is good and what is not?

Autor: Alexis Mitchell, Ashlee E. Watts, Frank H. Ebetino, Larry J. Suva

Publikováno v: BMC Veterinary Research, Vol 15, Iss 1, Pp 1-7 (2019)

Abstract Background Bisphosphonates (BPs) are a family of molecules characterized by two key properties: their ability to bind strongly to bone mineral and their inhibitory effects on mature osteoclasts and thus bone resorption. Chemically two groups

Externí odkaz: https://doaj.org/article/1e6238d214f141d5b2107b1073d3a2f7

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