Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Frank H, Niesen"'
Autor:
Frank H Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J Maloney, Ewa S Pilka, Minghua Wang, Udo Oppermann, Tom D Heightman, Anton Simeonov
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13719 (2010)
15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation. The anabolic pathways of prostaglandins, especially with respect to re
Externí odkaz:
https://doaj.org/article/da1276c059c2465cb83ff8f287ef16f9
Autor:
Peter Rellos, Ashley C W Pike, Frank H Niesen, Eidarus Salah, Wen Hwa Lee, Frank von Delft, Stefan Knapp
Publikováno v:
PLoS Biology, Vol 8, Iss 7, p e1000426 (2010)
UnlabelledLong-term potentiation (LTP), a long-lasting enhancement in communication between neurons, is considered to be the major cellular mechanism underlying learning and memory. LTP triggers high-frequency calcium pulses that result in the activa
Externí odkaz:
https://doaj.org/article/0d7234b8593f433581b50ed7155a6727
Autor:
Ewa S Pilka, Frank H Niesen, Wen Hwa Lee, Yasser El-Hawari, James E Dunford, Grazyna Kochan, Vladimir Wsol, Hans-Joerg Martin, Edmund Maser, Udo Oppermann
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7113 (2009)
Carbonyl reduction constitutes a phase I reaction for many xenobiotics and is carried out in mammals mainly by members of two protein families, namely aldo-keto reductases and short-chain dehydrogenases/reductases. In addition to their capacity to re
Externí odkaz:
https://doaj.org/article/9952e0bf45994e3c9d214efdae5d684b
Autor:
Ashley C. W. Pike, Stefan Knapp, Frank H. Niesen, P. Rellos, Wen Hwa Lee, Frank von Delft, Eidarus Salah
Publikováno v:
PLoS Biology
PLoS Biology, Vol 8, Iss 7, p e1000426 (2010)
PLoS Biology, Vol 8, Iss 7, p e1000426 (2010)
Structural and biophysical studies reveal how CaMKII kinases, which are important for cellular learning and memory, are switched on by binding of Ca2+/calmodulin.
Long-term potentiation (LTP), a long-lasting enhancement in communication between
Long-term potentiation (LTP), a long-lasting enhancement in communication between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a9096397fc11969fb20dfe52e0ea9a
https://doi.org/10.1371/journal.pbio.1000426
https://doi.org/10.1371/journal.pbio.1000426
Autor:
Frank H. Niesen, S. Healy, D S Froese, M McDonald, Grazyna Kochan, Udo Oppermann, Roy A. Gravel
Publikováno v:
Molecular Genetics and Metabolism
Methylmalonic aciduria and homocystinuria, cblC type, is the most common inborn error of cellular vitamin B12 metabolism. We previously showed that the protein carrying the mutation responsible for late-onset cblC (MMACHC-R161Q), treatable with high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e84616d07c511affde84327170e405f
https://doi.org/10.1016/j.ymgme.2010.02.005
https://doi.org/10.1016/j.ymgme.2010.02.005
Autor:
Stefan Knapp, Gregor B. Deutsch, Hana Kunkel, Frank McKeon, Elisabeth M. Zielonka, Amparo Acker-Palmer, Birgit Schäfer, Frank H. Niesen, Jens Hannewald, Laura M. Luh, D. Coutandin, Jan Hoffmann, Tobias Alexander Weber, Volker Dötsch, Aycan Sentürk, Florian Durst, Manuel Grez, Mohamed Ibrahim, Bernd Brutschy, Enrico Schleiff
Publikováno v:
Cell
Summary TAp63α, a homolog of the p53 tumor suppressor, is a quality control factor in the female germline. Remarkably, already undamaged oocytes express high levels of the protein, suggesting that TAp63α's activity is under tight control of an inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4596fd321a16292794b27f5e397b212
https://doi.org/10.1016/j.cell.2011.01.013
https://doi.org/10.1016/j.cell.2011.01.013
Autor:
Sanjan Das, E. Papagrigoriou, Suhyung Cho, Alex N. Bullock, Benjamin E. Turk, Judit É. Debreczeni, Frank H. Niesen, Stefan Knapp, Oleg Fedorov, P. Rellos, Kunde Guo, Gourisankar Ghosh, A. Amos
Publikováno v:
Structure(London, England:1993)
Summary Splicing requires reversible phosphorylation of serine/arginine-rich (SR) proteins, which direct splice site selection in eukaryotic mRNA. These phosphorylation events are dependent on SR protein (SRPK) and cdc2-like kinase (CLK) families. SR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d305980da87e514752b9d16b2163c2
Autor:
Frank H. Niesen, Laurence H. Pearl, Sirlester A. Parker, Antony W. Oliver, Benjamin E. Turk, Ashley C. W. Pike, Stefan Knapp, P. Rellos, Andrew P. Turnbull
Publikováno v:
The EMBO Journal
Protein kinase autophosphorylation of activation segment residues is a common regulatory mechanism in phosphorylation-dependent signalling cascades. However, the molecular mechanisms that guarantee specific and efficient phosphorylation of these site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba031f1dffd13a6dfdc63b8e0d8b07b3
https://doi.org/10.1038/emboj.2008.8
https://doi.org/10.1038/emboj.2008.8
Autor:
Oppermann Uct., Michael Sundström, Brian D. Marsden, Declan A. Doyle, F. von Delft, Frank H. Niesen, Stefan Knapp, Susanne Müller, Linda J. Ball, Opher Gileadi, Wen Hwa Lee, Kathryn L. Kavanagh
Publikováno v:
Journal of Structural and Functional Genomics
As many of the structural genomics centers have ended their first phase of operation, it is a good point to evaluate the scientific impact of this endeavour. The Structural Genomics Consortium (SGC), operating from three centers across the Atlantic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a695f629f294d1cba917f758cd6d881f
https://doi.org/10.1007/s10969-007-9027-2
https://doi.org/10.1007/s10969-007-9027-2
Autor:
Konrad Büssow, Yvette Roske, Frank Götz, Babu A. Manjasetty, Christoph Scheich, Johan Gobom, Frank H. Niesen, Martin Fieber-Erdmann, Udo Heinemann
Publikováno v:
Protein Science. 15:914-920
The human protein PTD012 is the longer product of an alternatively spliced gene and was described to be localized in the nucleus. The X-ray structure analysis at 1.7 A resolution of PTD012 through SAD phasing reveals a monomeric protein and a novel f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b2f50f33afd39a94cf991a0a896249
https://doi.org/10.1110/ps.052037006
https://doi.org/10.1110/ps.052037006