Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Frank H, Ebetino"'
Autor:
Zhenqiang Yao, Akram Ayoub, Venkatesan Srinivasan, Jun Wu, Churou Tang, Rong Duan, Aleksa Milosavljevic, Lianping Xing, Frank H. Ebetino, Alison J. Frontier, Brendan F. Boyce
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone formation, while the anabolic agent, teriparatide, does not inhibit bone resorption, and thus they have limited efficacy in
Externí odkaz:
https://doaj.org/article/9342ddf34d9e437d96b8b870a032df6e
Autor:
Youliang Ren, Jason Weeks, Thomas Xue, Joshua Rainbolt, Karen L. de Mesy Bentley, Ye Shu, Yuting Liu, Elysia Masters, Philip Cherian, Charles E. McKenna, Jeffrey Neighbors, Frank H. Ebetino, Edward M. Schwarz, Shuting Sun, Chao Xie
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achiev
Externí odkaz:
https://doaj.org/article/96b573a5a803436d94a93195b6f70cb2
Autor:
Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Oskar Sundberg, Jesus J. Campagna, Boris A. Kashemirov, Varghese John, Shuting Sun, Frank H. Ebetino, Charles E. McKenna, Ichiro Nishimura
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-17 (2022)
Okawa et al. evaluate a fluorescent risedronate analogue, 800CW-pRIS, as a potential treatment for medication-related osteonecrosis of the jaw. The authors demonstrate an improvement in wound healing and inflammation with 800CW-pRIS pre-treatment in
Externí odkaz:
https://doaj.org/article/fa4c14d86d1e48f7abda46536e834eaf
Autor:
Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Jesus J Campagna, Nicholas A Lentini, Eric C Sung, Samantha Chiang, Yi-Ling Lin, Frank H Ebetino, Varghese John, Shuting Sun, Charles E McKenna, Ichiro Nishimura
Publikováno v:
eLife, Vol 11 (2022)
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents as a morbid jawbone lesion in patients exposed to a nitrogen-containing bisphosphonate (N-BP). Although it is rare, BRONJ has caused apprehension among patients and healthcare providers
Externí odkaz:
https://doaj.org/article/e3ceccf5a73f432bb37f38fa3f67e062
Autor:
Youliang Ren, Thomas Xue, Joshua Rainbolt, Karen L. de Mesy Bentley, Chad A. Galloway, Yuting Liu, Philip Cherian, Jeffrey Neighbors, Marloes I. Hofstee, Frank H. Ebetino, Thomas Fintan Moriarty, Shuting Sun, Edward M. Schwarz, Chao Xie
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
S. aureus infection of bone is difficult to eradicate due to its ability to colonize the osteocyte-lacuno-canalicular network (OLCN), rendering it resistant to standard-of-care (SOC) antibiotics. To overcome this, we proposed two bone-targeted bispho
Externí odkaz:
https://doaj.org/article/bce85e9c2bad40a79c4e87db39e8c0b8
Autor:
Marcia A Munoz, Emma K Fletcher, Oliver P Skinner, Julie Jurczyluk, Esther Kristianto, Mark P Hodson, Shuting Sun, Frank H Ebetino, David R Croucher, Philip M Hansbro, Jacqueline R Center, Michael J Rogers
Publikováno v:
eLife, Vol 10 (2021)
Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to r
Externí odkaz:
https://doaj.org/article/efd2366c282f45e0a4b6b5d87db2968d
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-7 (2019)
Abstract Background Bisphosphonates (BPs) are a family of molecules characterized by two key properties: their ability to bind strongly to bone mineral and their inhibitory effects on mature osteoclasts and thus bone resorption. Chemically two groups
Externí odkaz:
https://doaj.org/article/1e6238d214f141d5b2107b1073d3a2f7
Autor:
Abigail A Coffman, Jelena Basta‐Pljakic, Rosa M Guerra, Frank H Ebetino, Mark W Lundy, Robert J Majeska, Mitchell B Schaffler
Publikováno v:
JBMR Plus, Vol 5, Iss 7, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/39b83b895613419fbd0d9763b0efaee3
Autor:
Abigail A Coffman, Jelena Basta‐Pljakic, Rosa M Guerra, Frank H Ebetino, Mark W Lundy, Robert J Majeska, Mitchell B Schaffler
Publikováno v:
JBMR Plus, Vol 5, Iss 4, Pp n/a-n/a (2021)
ABSTRACT Bisphosphonates (BPs) are a mainstay of osteoporosis treatment; however, concerns about bone health based on oversuppression of remodeling remain. Long‐term bone remodeling suppression adversely affects bone material properties with microd
Externí odkaz:
https://doaj.org/article/7379c21f04d841a7a77d926f4a2a7532
Autor:
Emmanuela Adjei-Sowah, Yue Peng, Jason Weeks, Jennifer H. Jonason, Karen L. de Mesy Bentley, Elysia Masters, Yugo Morita, Gowrishankar Muthukrishnan, Philip Cherian, X. Eric Hu, Charles E. McKenna, Frank H. Ebetino, Shuting Sun, Edward M. Schwarz, Chao Xie
Publikováno v:
Antibiotics, Vol 10, Iss 6, p 732 (2021)
The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about Staphylococcus aureus colonization of the osteocyte-lacuno canalicular network (OLCN). Here we propose bisphos
Externí odkaz:
https://doaj.org/article/55d8be3a8e344453a7cad2e4bff9c98b