Výsledky vyhledávání - "Frank Girbig"

Akademický článek

Substrate specificity of the ileal and the hepatic Na+/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters

Autor: Werner Kramer, Siegfried Stengelin, Karl-Heinz Baringhaus, Alfons Enhsen, Hubert Heuer, Wolfgang Becker, Daniel Corsiero, Frank Girbig, Rüdiger Noll, Claudia Weyland

Publikováno v: Journal of Lipid Research, Vol 40, Iss 9, Pp 1604-1617 (1999)

The substrate specificity of the ileal and the hepatic Na+/bile acid cotransporters was determined using brush border membrane vesicles and CHO cell lines permanently expressing the Na+/bile acid cotransporters from rabbit ileum or rabbit liver. The

Externí odkaz: https://doaj.org/article/0bd38c9e399a469881c5111bbb621130

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Intestinal cholesterol absorption: identification of different binding proteins for cholesterol and cholesterol absorption inhibitors in the enterocyte brush border membrane

Autor: Frank Girbig, Günter Müller, Katja Burger, Werner Kramer, Falk Fahrenholz, Christian Jung, Daniel Corsiero

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1633:13-26

Absorption of cholesterol from the intestine is a central part of body cholesterol homeostasis. The molecular mechanisms of intestinal cholesterol absorption and the proteins mediating membrane transport are not known. We therefore aimed to identify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f2f007e6c24bb319797b37e4ee1274
https://doi.org/10.1016/s1388-1981(03)00068-4

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Identification of the Bile Acid-binding Site of the Ileal Lipid-binding Protein by Photoaffinity Labeling, Matrix-assisted Laser Desorption Ionization-Mass Spectrometry, and NMR Structure

Autor: Waltraud König, Frank Girbig, Klaus Sauber, Claudia Weyland, Michael Kurz, Daniel Corsiero, Gudrun Lange, Siegfried Stengelin, Karl-Heinz Baringhaus, Werner Kramer

Publikováno v: Journal of Biological Chemistry. 276:7291-7301

The ileal lipid-binding protein (ILBP) is the only physiologically relevant bile acid-binding protein in the cytosol of ileocytes. To identify the bile acid-binding site(s) of ILBP, recombinant rabbit ILBP photolabeled with 3-azi- and 7-azi-derivativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd1496ab90357a13416cce1dcfbb9de
https://doi.org/10.1074/jbc.m006877200

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Identification of binding proteins for cholesterol absorption inhibitors as components of the intestinal cholesterol transporter

Autor: Daniel Corsiero, Wolfgang Wendler, Hubert Heuer, Frank Girbig, Werner Kramer, Heiner Glombik, Stephan Petry, Claudia Weyland, Hans-Ludwig Schäfer

Publikováno v: FEBS Letters. 487:293-297

To identify protein components of the intestinal cholesterol transporter, rabbit small intestinal brush border membrane vesicles were submitted to photoaffinity labeling using photoreactive derivatives of 2-azetidinone cholesterol absorption inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feba5699c48d723146727daa45fc969a
https://doi.org/10.1016/s0014-5793(00)02372-3

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Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling

Autor: Werner Kramer, William J. Arion, Claudia Weyland, Burger Hans-Joerg, Stefan Petry, Frank Girbig, Daniel Corsiero, Paul Habermann, Horst Hemmerle, Andreas W. Herling

Publikováno v: Biochemical Journal. 339:629-638

The glucose-6-phosphatase system catalyses the terminal step of hepatic glucose production from both gluconeogenesis and glycogenolysis and is thus a key regulatory factor of blood glucose homoeostasis. To identify the glucose 6-phosphate transporter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8cd5bb7261d64d1eab0f51963395d3
https://doi.org/10.1042/bj3390629

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Intestinal absorption of bile acids: paradoxical behaviour of the 14 kDa ileal lipid-binding protein in differential photoaffinity labelling

Autor: Siegfried Stengelin, Frank Girbig, Michael G. Friedrich, Werner Kramer, Claudia Weyland, Daniel Corsiero

Publikováno v: Biochemical Journal. 333:335-341

Photoaffinity labelling of brush border membrane vesicles from rabbit ileum with radiolabelled 3,3-azo and 7,7-azo derivatives of taurocholate identified integral membrane proteins of molecular masses 93 and 46 kDa, as well as a 14 kDa peripheral mem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e77f0efbc5807f191a18797cf56366
https://doi.org/10.1042/bj3330335

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Topological Photoaffinity Labeling of the Rabbit Ileal Na+/Bile-Salt-Cotransport System

Autor: Daniel Corsiero, Claudia Weyland, Hans-Ludwig Schäfer, Siegfried Stengelin, Frank Girbig, Alfons Enhsen, Günther Wess, Werner Kramer, Klaus Bock, Horst Kleine, Marie-Anne Le Dreau, Ulrike Bewersdorf

Publikováno v: European Journal of Biochemistry. 249:456-464

For the investigation of the topology of the rabbit ileal Na+/bile-salt-cotransport system, composed of a 93-kDa integral membrane protein and a peripheral 14-kDa bile-acid-binding protein (ILBP), we have synthesized photolabile dimeric bile-salt-tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9775ed4af019f8ef23ee2083a2b14854
https://doi.org/10.1111/j.1432-1033.1997.00456.x

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The molecular interaction of sulfonylureas with β-cell ATP-sensitive K+-channels

Autor: Werner Kramer, Hans-Dieter Summ, Simone Kowalewski, Günter Müller, Ulrike Gutjahr, Detlef Hartz, Frank Girbig

Publikováno v: Diabetes Research and Clinical Practice. 28:S67-S80

The molecular interaction of glimepiride and glibenclamide with the beta-cell sulfonylurea receptor was investigated by kinetic and steady state binding as well as photoaffinity labeling. The novel sulfonylurea, glimepiride, exhibits a significantly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061136b4bee42fad5dfedfdd91ed4fd6
https://doi.org/10.1016/0168-8227(95)01076-p

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Interaction of the orally active dianionic cephalosporin cefixime with the uptake system for oligopeptides and α-amino-β-lactam antibiotics in rabbit small intestine

Autor: Frank Girbig, Ulrike Gutjahr, Simone Kowalewski, Werner Kramer

Publikováno v: Biochemical Pharmacology. 46:542-546

The uptake of two orally active β-lactam antibiotics of different chemical structure, the zwitterionic or-aminocephalosporin cephalexin and the dianionic carboxymethoxyimino-cephalosporin cefixime, by brush border membrane vesicles obtained from rab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6b72012e59b8d9c20d63b3e9000656
https://doi.org/10.1016/0006-2952(93)90533-3

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Intestinal bile acid absorption. Na(+)-dependent bile acid transport activity in rabbit small intestine correlates with the coexpression of an integral 93-kDa and a peripheral 14-kDa bile acid-binding membrane protein along the duodenum-ileum axis

Autor: Frank Girbig, Günter Müller, Karin Jouvenal, Simone Kowalewski, Ulrike Gutjahr, Günther Wess, Werner Kramer, Dominique Tripier

Publikováno v: Scopus-Elsevier

The anatomical localization of the Na+/bile acid cotransport system from rabbit small intestine was determined using brush border membrane vesicles prepared from eight different segments of the small intestine. Na(+)-dependent transport activity for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2672068e710221aa38d1a93605c9bb1a
https://doi.org/10.1016/s0021-9258(17)46808-6

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