Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Frank G van Steenbeek"'
Autor:
Lindsay Van den Bossche, Vivien A C Schoonenberg, Iwan A Burgener, Louis C Penning, Ingrid M Schrall, Hedwig S Kruitwagen, Monique E van Wolferen, Guy C M Grinwis, Anne Kummeling, Jan Rothuizen, Jeroen F van Velzen, Nikolas Stathonikos, Martijn R Molenaar, Bernd J Helms, Jos F H M Brouwers, Bart Spee, Frank G van Steenbeek
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186491 (2017)
Non-alcoholic fatty liver disease (NAFLD) is a poorly understood multifactorial pandemic disorder. One of the hallmarks of NAFLD, hepatic steatosis, is a common feature in canine congenital portosystemic shunts. The aim of this study was to gain deta
Externí odkaz:
https://doaj.org/article/d24b3c0da950484b9acfde4701c548bc
Autor:
Karen Dirksen, Bart Spee, Louis C Penning, Ted S G A M van den Ingh, Iwan A Burgener, Adrian L Watson, Marian Groot Koerkamp, Jan Rothuizen, Frank G van Steenbeek, Hille Fieten
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176826 (2017)
Copper is an essential trace element, but can become toxic when present in abundance. The severe effects of copper-metabolism imbalance are illustrated by the inherited disorders Wilson disease and Menkes disease. The Labrador retriever dog breed is
Externí odkaz:
https://doaj.org/article/155dbf7dcdcf4302b3c3d9be1711c65e
Autor:
Kim M Boerkamp, Frank G van Steenbeek, Louis C Penning, Marian J A Groot Koerkamp, Dik van Leenen, Manon Vos-Loohuis, Guy C M Grinwis, Gerard R Rutteman
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98258 (2014)
Examination of gene functions in specific tumor types improves insight in tumorigenesis and helps design better treatments. Due to the rarity of histiocytic/dendritic cell sarcoma in humans, it is difficult to accrue such knowledge. Therefore, compar
Externí odkaz:
https://doaj.org/article/5953b5baa67b45e38fafc5a9485419c5
Autor:
Giora van Straten, Frank G van Steenbeek, Guy C M Grinwis, Robert P Favier, Anne Kummeling, Ingrid H van Gils, Hille Fieten, Marian J A Groot Koerkamp, Frank C P Holstege, Jan Rothuizen, Bart Spee
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100077 (2014)
The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital portosystemic shunts (CPSS) in dogs cause hyperammonemia eventually leading to hepatic encephalopath
Externí odkaz:
https://doaj.org/article/7ede9a910425447ebd39719c1003e49c
Autor:
Kim M Boerkamp, Marieke van der Kooij, Frank G van Steenbeek, Monique E van Wolferen, Marian J A Groot Koerkamp, Dik van Leenen, Guy C M Grinwis, Louis C Penning, Erik A C Wiemer, Gerard R Rutteman
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71094 (2013)
BackgroundThe determination of altered expression of genes in specific tumor types and their effect upon cellular processes may create insight in tumorigenesis and help to design better treatments. The Flatcoated retriever is a dog breed with an exce
Externí odkaz:
https://doaj.org/article/cb03fb412bee43de96f6241999709856
Autor:
Frank G van Steenbeek, Lindsay Van den Bossche, Guy C M Grinwis, Anne Kummeling, Ingrid H M van Gils, Marian J A Groot Koerkamp, Dik van Leenen, Frank C P Holstege, Louis C Penning, Jan Rothuizen, Peter A J Leegwater, Bart Spee
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57662 (2013)
Congenital portosystemic shunts are developmental anomalies of the splanchnic vascular system that cause portal blood to bypass the liver. Large-breed dogs are predisposed for intrahepatic portosystemic shunts (IHPSS) and small-breed dogs for extrahe
Externí odkaz:
https://doaj.org/article/dda79935d0604c539e63ad79c5d6d0d2
Autor:
Frank G van Steenbeek, Bart Spee, Louis C Penning, Anne Kummeling, Ingrid H M van Gils, Guy C M Grinwis, Dik Van Leenen, Frank C P Holstege, Manon Vos-Loohuis, Jan Rothuizen, Peter A J Leegwater
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57973 (2013)
The aryl hydrocarbon receptor (AHR) mediates biological responses to toxic chemicals. An unexpected role for AHR in vascularization was suggested when mice lacking AHR displayed impaired closure of the ductus venosus after birth, as did knockout mice
Externí odkaz:
https://doaj.org/article/57ee54ac0a5c4620a12a23b0c1f1de9e
Autor:
Annemarie M W Y Voorbij, Frank G van Steenbeek, Manon Vos-Loohuis, Ellen E C P Martens, Jeanette M Hanson-Nilsson, Bernard A van Oost, Hans S Kooistra, Peter A Leegwater
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27940 (2011)
Dwarfism in German shepherd dogs is due to combined pituitary hormone deficiency of unknown genetic cause. We localized the recessively inherited defect by a genome wide approach to a region on chromosome 9 with a lod score of 9.8. The region contain
Externí odkaz:
https://doaj.org/article/30a4258425b541769fd6f3fe2e961ffa
Autor:
Julia E. Niskanen, Åsa Ohlsson, Ingrid Ljungvall, Michaela Drögemüller, Robert F. Ernst, Dennis Dooijes, Hanneke W. M. van Deutekom, J. Peter van Tintelen, Christian J. B. Snijders Blok, Marion van Vugt, Jessica van Setten, Folkert W. Asselbergs, Aleksandra Domanjko Petrič, Milla Salonen, Sruthi Hundi, Matthias Hörtenhuber, DoGA consortium, Juha Kere, W. Glen Pyle, Jonas Donner, Alex V. Postma, Tosso Leeb, Göran Andersson, Marjo K. Hytönen, Jens Häggström, Maria Wiberg, Jana Friederich, Jenny Eberhard, Magdalena Harakalova, Frank G. van Steenbeek, Gerhard Wess, Hannes Lohi
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-21 (2023)
Abstract Background Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiolog
Externí odkaz:
https://doaj.org/article/49a1dbcf15a6421cbf422ecc2a464ea9
Autor:
Talitha C. F. Spanjersberg, Loes A. Oosterhoff, Hedwig S. Kruitwagen, Noortje A. M. van den Dungen, Johannes C. M. Vernooij, Folkert W. Asselbergs, Michal Mokry, Bart Spee, Magdalena Harakalova, Frank G. van Steenbeek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Vascular pathologies show locational predisposition throughout the body; further insights into the transcriptomics basis of this vascular heterogeneity are needed. We analyzed transcriptomes from cultured endothelial cells and vascular smoot
Externí odkaz:
https://doaj.org/article/084d9af137ee4c1b8e300e79be3a0038