Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Frank G Schaap"'
Autor:
Min Deng, Jianhua Cao, Gregory van derKroft, David P.J. vanDijk, Merel R. Aberle, Andrej Grgic, Ulf P. Neumann, Georg Wiltberger, Benjamin Balluff, Frank G. Schaap, Ron M.A. Heeren, Steven W.M. Olde Damink, Sander S. Rensen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 4, Pp 1283-1297 (2024)
Abstract Background Cancer cachexia is a multifactorial metabolic syndrome characterized by systemic inflammation and ongoing skeletal muscle loss resulting in weakness, poor quality of life, and decreased survival. Whereas lipid accumulation in skel
Externí odkaz:
https://doaj.org/article/a21945d9b4a94f918dbf70a8e0d468eb
Autor:
Pieter F de Groot, Clara Belzer, Ömrüm Aydin, Evgeni Levin, Johannes H Levels, Steven Aalvink, Fransje Boot, Frits Holleman, Daniël H van Raalte, Torsten P Scheithauer, Suat Simsek, Frank G Schaap, Steven W M Olde Damink, Bart O Roep, Joost B Hoekstra, Willem M de Vos, Max Nieuwdorp
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188475 (2017)
Environmental factors driving the development of type 1 diabetes (T1D) are still largely unknown. Both animal and human studies have shown an association between altered fecal microbiota composition, impaired production of short-chain fatty acids (SC
Externí odkaz:
https://doaj.org/article/35ce42c8358848c681d62d25dcb52ce0
Autor:
Rian M Nijmeijer, Frank G Schaap, Alexander J J Smits, Andreas E Kremer, Louis M A Akkermans, Alfons B A Kroese, Ger T Rijkers, Marguerite E I Schipper, André Verheem, Cisca Wijmenga, Hein G Gooszen, Karel J van Erpecum
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114393 (2014)
BackgroundInfectious complications often occur in acute pancreatitis, related to impaired intestinal barrier function, with prolonged disease course and even mortality as a result. The bile salt nuclear receptor farnesoid X receptor (FXR), which is e
Externí odkaz:
https://doaj.org/article/a9b09a5f7a1f4adeae6d1651cb798c1f
Autor:
Lin Chen, Montserrat Elizalde, Ludwig J. Dubois, Anjali A. Roeth, Ulf P. Neumann, Steven W. M. Olde Damink, Frank G. Schaap, Gloria Alvarez-Sola
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7279 (2024)
Cholangiocarcinoma (CCA), or bile duct cancer, is the second most common liver malignancy, with an increasing incidence in Western countries. The lack of effective treatments associated with the absence of early symptoms highlights the need to search
Externí odkaz:
https://doaj.org/article/9fe8c6e7562448c9b1dae0bfb1890b61
Autor:
Fiona D M van Schaik, Raffaella M Gadaleta, Frank G Schaap, Saskia W C van Mil, Peter D Siersema, Bas Oldenburg, Karel J van Erpecum
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49706 (2012)
BACKGROUND: The bile acid-activated nuclear receptor Farnesoid X Receptor (FXR) is critical in maintaining intestinal barrier integrity and preventing bacterial overgrowth. Patients with Crohn's colitis (CC) exhibit reduced ileal FXR target gene expr
Externí odkaz:
https://doaj.org/article/16ddd1b4568e479a8bf918a868c7b346
Autor:
Soumia Majait, Emma C. E. Meessen, Mark Davids, Youssef Chahid, Steven W. Olde Damink, Frank G. Schaap, Ellis Marleen Kemper, Max Nieuwdorp, Maarten R. Soeters
Publikováno v:
Microorganisms, Vol 12, Iss 4, p 764 (2024)
Ageing changes the impact of nutrition, whereby inflammation has been suggested to play a role in age-related disabilities such as diabetes and cardiovascular disease. The aim of this study was to investigate differences in postprandial bile-acid res
Externí odkaz:
https://doaj.org/article/c3ae8cb37f4346f9aaae2b749679b0c6
Autor:
Soumia Majait, Emma C. E. Meessen, Frederic Maxime Vaz, E. Marleen Kemper, Samuel van Nierop, Steven W. Olde Damink, Frank G. Schaap, Johannes A. Romijn, Max Nieuwdorp, Aad Verrips, Filip Krag Knop, Maarten R. Soeters
Publikováno v:
Nutrients, Vol 15, Iss 21, p 4625 (2023)
Cerebrotendinous xanthomatosis (CTX) is a rare inherited disease characterized by sterol 27-hydroxylase (CYP27A1) deficiency and, thus, a lack of bile acid synthesis with a marked accumulation of 7α-hydroxylated bile acid precursors. In addition to
Externí odkaz:
https://doaj.org/article/30a1913f292d42df954fa2300b9ef17c
Autor:
Min Deng, Merel R. Aberle, Annemarie A. J. H. M. van Bijnen, Gregory van der Kroft, Kaatje Lenaerts, Ulf P. Neumann, Georg Wiltberger, Frank G. Schaap, Steven W. M. Olde Damink, Sander S. Rensen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCancer cachexia is a multifactorial syndrome characterized by body weight loss and systemic inflammation. The characterization of the inflammatory response in patients with cachexia is still limited. Lipocalin-2, a protein abundant in neutr
Externí odkaz:
https://doaj.org/article/f7a05063d9a6462bb0835ebb4990c14f
Autor:
Sven-Bastiaan Haange, Andreas Till, Per-Olof Bergh, Günter Fauler, Michael Gigl, Anita Löfgren-Sandblom, Frank G. Schaap, Thomas Clavel, Christian Trautwein, Wiebke Fenske, Karin Kleigrewe, Hanns-Ulrich Marschall, Steven W. M. Olde Damink, Tarek Moustafa, Martin von Bergen, Ulrike Rolle-Kampczyk
Publikováno v:
Metabolites, Vol 12, Iss 7, p 583 (2022)
Bile acids are a key mediator of the molecular microbiome-host interaction, and various mass spectrometry-based assays have been developed in the recent decade to quantify a wide range of bile acids. We compare existing methodologies to harmonize the
Externí odkaz:
https://doaj.org/article/16aa1179c4a84830b82e4514f6c3fd24
Publikováno v:
Nature Reviews Gastroenterology & Hepatology.
The gut and the liver are characterized by mutual interactions between both organs, the microbiome, diet and other environmental factors. The sum of these interactions is conceptualized as the gut-liver axis. In this Review we discuss the gut-liver a