Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Frank G, Bottone"'
Autor:
Shirley Musich PhD, Stephanie MacLeod MS, Gandhi R. Bhattarai PhD, Shaohung S. Wang PhD, Kevin Hawkins PhD, Frank G. Bottone RDN, PhD, Charlotte S. Yeh MD
Publikováno v:
Gerontology and Geriatric Medicine, Vol 2 (2016)
Objective: Obesity is a contributor to increased chronic conditions resulting in higher utilization of medical services among broad populations of older adults. The objective of this study was to evaluate the magnitude of the impact of weight on heal
Externí odkaz:
https://doaj.org/article/3d543aa4ae874edfb2ebe1b5a551a89f
Autor:
Patricia LoRusso, Drew W. Rasco, Geoffrey Shapiro, Alain C. Mita, Nilofer Saba Azad, Paul Swiecicki, Anthony B. El-Khoueiry, David R. Gandara, Shivaani Kummar, Hovig Tanajian, Jaruwan Taylor, Frank G Bottone, Marchi Toguchi, Chris Hindley, Danna Chan, Aram Oganesian, Harold N. Keer, Kim-Hien T Dao, Ryan J. Sullivan, Alexander I. Spira
Publikováno v:
Journal of Clinical Oncology. 40:9085-9085
9085 Background: Aberrant activation of the RAS-RAF-MEK-ERK pathway is common in human cancers. This is an open-label Phase 1 study of ASTX029, a dual-mechanism extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor, in subjects with relapsed/r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e2dc61f2b997ce28f5fcf7b51aaeaca
https://doi.org/10.1200/jco.2022.40.16_suppl.9085
https://doi.org/10.1200/jco.2022.40.16_suppl.9085
Autor:
Tod O'Donovan, Janelle G. Ekness, Kevin Hawkins, Charlotte S. Yeh, Cynthia Barnowski, Meg Lamm, Richard J. Migliori, Ronald J. Ozminkowski, Frank G. Bottone, Karen Valerio, Nancy Dodd, Andrea Levy, Michelle LeGros
Publikováno v:
Women's Health Issues. 22:e473-e482
Background Many women with coronary artery disease (CAD), commonly referred to as coronary heart disease, do not receive an annual office visit to manage their disease. We set out to determine what barriers factor into women not receiving an office v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e3fc8f36a6221adee4c3d9508728ed
https://doi.org/10.1016/j.whi.2012.06.001
https://doi.org/10.1016/j.whi.2012.06.001
Autor:
Richard J. Migliori, Ming Bai, Cynthia E. Hommer, Shirley Musich, Frank G. Bottone, Jürgen Unützer, Kevin Hawkins, Charlotte S. Yeh, Ronald J. Ozminkowski
Publikováno v:
International Journal of Geriatric Psychiatry. 27:948-958
OBJECTIVE: This study aims to estimate the burden of currently having depressive symptoms on quality of life independently and in combination with various chronic conditions/health concerns among adults with Medicare Supplement Insurance (i.e., Medig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c90d87635b41a4ec2fc70dcc4f4374e
https://doi.org/10.1002/gps.2806
https://doi.org/10.1002/gps.2806
Autor:
Frank G. Bottone, Shirley Musich, Kevin Hawkins, Ronald J. Ozminkowski, Ming Bai, Charlotte S. Yeh, Richard J. Migliori
Publikováno v:
Quality of Life Research. 21:1135-1147
To estimate the impact of hearing impairment on quality of life from a physical and mental standpoint.Data were obtained from the Health Update Survey, which contains questions on demographics, comorbid conditions, and the Veterans RAND 12-item healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3df2454f42209c0edad3e2ee681c75
https://doi.org/10.1007/s11136-011-0028-z
https://doi.org/10.1007/s11136-011-0028-z
Autor:
Brenda Alston-Mills, Frank G. Bottone
Publikováno v:
Journal of Medicinal Food. 14:584-593
Various chemopreventive compounds alter gene expression, possibly explaining their biological activity. One gene induced by a variety of chemopreventive compounds is the one coding for the transcription factor activating transcription factor 3 (ATF3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4826ed6715a577d01920eac41cb55c0f
https://doi.org/10.1089/jmf.2010.0110
https://doi.org/10.1089/jmf.2010.0110
Autor:
Frank G. Bottone, William T. Barry
Publikováno v:
Current Medical Research and Opinion. 25:1535-1550
The authors performed a postmarketing database analysis to evaluate the incidence of cardiovascular and other serious adverse events (SAEs) reported to the US Food and Drug Administration's Adverse Event Reporting System (AERS) involving the use of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94757716a9b5b0ce11c48ab98a04d67
https://doi.org/10.1185/03007990902953286
https://doi.org/10.1185/03007990902953286
Publikováno v:
Molecular Cancer Therapeutics. 4:1551-1558
Cyclooxygenase (COX) inhibitors have antitumorigenic activity and increase the expression of the early growth response gene Egr-1, a tumor suppressor gene and transcription factor. In this study, we have investigated the gene regulatory and anti-inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6379717995a3159d03e57f10fb66bd7
https://doi.org/10.1158/1535-7163.mct-05-0213
https://doi.org/10.1158/1535-7163.mct-05-0213
Publikováno v:
Molecular Cancer Research. 3:511-517
To investigate the function of 15-lipoxygenase-1 (15-LOX-1) in human colorectal cancer, we overexpressed 15-LOX-1 in HCT-116 human colorectal cancer cells. Clones expressing the highest levels of 15-LOX-1 displayed reduced viability compared with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6893524103de8751374f2e62d3f89dc2
https://doi.org/10.1158/1541-7786.mcr-05-0011
https://doi.org/10.1158/1541-7786.mcr-05-0011
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:668-677
Previously, our laboratory identified activating transcription factor 3 (ATF3) as up-regulated by nonsteroidal anti-inflammatory drugs using microarray analysis of mRNA from human colorectal cancer cells treated with sulindac sulfide. ATF3 is a trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39038a49e18b10c899fac7885496f9f
https://doi.org/10.1124/jpet.105.089607
https://doi.org/10.1124/jpet.105.089607