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of 65
pro vyhledávání: '"Frank Fleischer"'
Publikováno v:
Statistics in Biosciences. 14:413-431
Traditionally, dose-finding process for oncology compound is carried out in phase I dose escalation study and is driven by safety in order to find maximum tolerated dose (MTD). However, with the recent paradigm shift from cytotoxic drugs to new gener
The Multiple Comparison Procedure and Modelling (MCPMod) approach has been shown to be a powerful statistical tool that can significantly improve the design and analysis of dose finding studies under model uncertainty. Due to its frequentist nature,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd6381d395a280e110ae4cc32f7601e
https://doi.org/10.1101/2022.03.12.22272175
https://doi.org/10.1101/2022.03.12.22272175
Publikováno v:
Pharmaceutical statisticsREFERENCES. 21(3)
Multiple comparison procedures and modeling (MCPMod) has established itself as a method for dose-finding under model uncertainty. A downside of MCPMod is that due to its frequentist nature in particular with respect to the multiple comparison part it
Publikováno v:
Statistical methods in medical research. 28(4)
After exploratory drug development, companies face the decision whether to initiate confirmatory trials based on limited efficacy information. This proof-of-concept decision is typically performed after a Phase II trial studying a novel treatment ver
Publikováno v:
European journal of clinical pharmacology. 74(5)
A drug is defined as highly variable if its intra-individual coefficient of variation (CV) is greater than or equal to 30%. In such a case, bioequivalence may be assessed by means of methods that take the (high) variability into account. The Scaled A
Autor:
Frank Fleischer, Torsten Mattfeldt
Publikováno v:
Journal of Microscopy. 256:46-60
In the present study, 53 cases of squamous cell carcinomas of the head and neck were characterized by a quantitative histological texture analysis based on principles of spatial statistics. A planar tessellation of the epithelial tumour component was
Publikováno v:
Journal of Microscopy. 251:84-98
This paper deals with the estimation of the intensity of a planar point process on the basis of a single point pattern, observed in a rectangular window. If the model assumptions of stationarity and isotropy hold, the method of block bootstrapping ca
Autor:
Jochen Schütte, Frank Fleischer, Dirk Strumberg, Klaus Mross, M Merger, W E Aulitzky, Roland M Schmid, Max E. Scheulen, S Hollerbach, Gerd Munzert, Christian Dittrich
Publikováno v:
British Journal of Cancer
Background: BI 2536, a novel Polo-like kinase 1 inhibitor, was assessed in patients with unresectable advanced exocrine adenocarcinoma of the pancreas. Methods: The study employed a two-stage design. Randomised first-line patients received BI 2536 20
Publikováno v:
Statistics in Medicine. 30:3373-3386
A reliable determination of progression is of key importance in determining progression-free survival in oncology trials. An independent review of tumour assessments made by investigators is often implemented with the aim of reducing a possible bias.
Publikováno v:
Stochastic Models. 27:141-167
We consider a spatial stochastic model for telecommunication networks, the stochastic subscriber line model, and we investigate the distribution of the typical shortest path length between network components. Therefore, we derive a representation for