Výsledky vyhledávání - "Frank Echtermeyer"

Akademický článek

MitoNEET Protects HL-1 Cardiomyocytes from Oxidative Stress Mediated Apoptosis in an In Vitro Model of Hypoxia and Reoxygenation.

Autor: Anika Habener, Arpita Chowdhury, Frank Echtermeyer, Ralf Lichtinghagen, Gregor Theilmeier, Christine Herzog

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0156054 (2016)

The iron-sulfur cluster containing protein mitoNEET is known to modulate the oxidative capacity of cardiac mitochondria but its function during myocardial reperfusion injury after transient ischemia is unknown. The purpose of this study was to analyz

Externí odkaz: https://doaj.org/article/ad1fd922a40246a3a339e04f3ecd48b3

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Akademický článek

Syndecan-1 as a Regulator of Chemokine Function

Autor: Martin Götte, Frank Echtermeyer

Publikováno v: The Scientific World Journal, Vol 3, Pp 1327-1331 (2003)

Externí odkaz: https://doaj.org/article/109e0c69c0de403cb15286c63555b133

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Akademický článek

Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial Ischemia/Reperfusion Injury

Autor: Christine Herzog, Martina Schmitz, Bodo Levkau, Ilka Herrgott, Jan Mersmann, Jan Larmann, Kai Johanning, Michael Winterhalter, Jerold Chun, Frank Ulrich Müller, Frank Echtermeyer, Reinhard Hildebrand, Gregor Theilmeier

Publikováno v: Mediators of Inflammation, Vol 2010 (2010)

HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated sphingophospholipids have similar effects. We therefore examined if HDL-associated sphingosylph

Externí odkaz: https://doaj.org/article/9a7fbf5f493a40e6aeb456112e6149f7

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Distinct Mechanisms Account for In Vitro Activation and Sensitization of TRPV1 by the Porphyrin Hemin

Autor: Andreas Leffler, Frank Echtermeyer, Mirjam Eberhardt, Natalie E. Palmaers, Christine Herzog, Steffen B. Wiegand

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10856, p 10856 (2021)

TRPV1 mediates pain occurring during sickling episodes in sickle cell disease (SCD). We examined if hemin, a porphyrin released during intravascular hemolysis modulates TRPV1. Calcium imaging and patch clamp were employed to examine effects of hemin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43818fdccfd65c2529c62430d72ed21e
https://pubmed.ncbi.nlm.nih.gov/34639197

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Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2

Autor: Tabea C. Fricke, Frank Echtermeyer, Johannes Zielke, Jeanne de la Roche, Milos R. Filipovic, Stéphane Claverol, Christine Herzog, Makoto Tominaga, Ruth A. Pumroy, Vera Y. Moiseenkova-Bell, Peter M. Zygmunt, Andreas Leffler, Mirjam J. Eberhardt

Publikováno v: Proc Natl Acad Sci U S A

Thermosensitive transient receptor potential (TRP) ion channels detect changes in ambient temperature to regulate body temperature and temperature-dependent cellular activity. Rodent orthologs of TRP vanilloid 2 (TRPV2) are activated by nonphysiologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa71f241f25bdd8c76a2a9862e5eb6b4
https://doi.org/10.1073/pnas.1904332116

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Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling

Autor: Giulia De Rossi, Thomas Pap, Adelheid Korb-Pap, James R. Whiteford, U König, Denise Beckmann, L. Godmann, Katja Mühlenberg, Jessica Bertrand, Frank Echtermeyer, M. Bollmann, J. Sherwood

Publikováno v: Annals of the rheumatic diseases. 79(4)

ObjectiveSyndecan-4 (sdc4) is a cell-anchored proteoglycan that consists of a transmembrane core protein and glucosaminoglycan (GAG) side chains. Binding of soluble factors to the GAG chains of sdc4 may result in the dimerisation of sdc4 and the init

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5bc75a398b8a0aed9ba0bd594f4e38
https://pubmed.ncbi.nlm.nih.gov/32094158

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Syndecan-4 Modulates Epithelial Gut Barrier Function and Epithelial Regeneration in Experimental Colitis

Autor: Thomas Pap, Rudolf Mennigen, Dominik Bettenworth, Johanna Intemann, Peter Paruzel, M. Sambale, Phil Tepasse, Mareike Fröhling, Frank Echtermeyer, Andreas Lügering, Nina-Marie Tiemeyer, Tobias M. Nowacki, Athanasios Stratis, J. Sherwood, Markus Brückner

Publikováno v: Inflammatory Bowel Diseases. 24:2579-2589

Background The transmembrane heparan sulfate proteoglycan Syndecan-4 (Sdc4) plays an important role in the regulation of various inflammatory disorders. However, the involvement of Sdc4 in intestinal inflammation remains unknown. Therefore, we assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6341ccab08b4540ff59ca397d25650
https://doi.org/10.1093/ibd/izy248

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Sodium Channel Nav1.3 Is Expressed by Polymorphonuclear Neutrophils during Mouse Heart and Kidney Ischemia In Vivo and Regulates Adhesion, Transmigration, and Chemotaxis of Human and Mouse Neutrophils In Vitro

Autor: Frank Echtermeyer, Christine Herzog, Marit Poffers, Andreas Leffler, Faikah Güler, Axel Hage, Rongjun Chen, Anja Thorenz, Nathalie Bühne

Publikováno v: Anesthesiology. 128:1151-1166

Background Voltage-gated sodium channels generate action potentials in excitable cells, but they have also been attributed noncanonical roles in nonexcitable cells. We hypothesize that voltage-gated sodium channels play a functional role during extra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde04b2ce4cdb967e6b6a4f67db7f4bf
https://doi.org/10.1097/aln.0000000000002135

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Effect of Clopidogrel on Thrombus Formation in an Ex Vivo Parallel Plate Flow Chamber Model Cannot Be Reversed by Addition of Platelet Concentrates or vWF Concentrate

Autor: Uwe Küster, Simone Calmer, Andreas Schäfer, Frank Echtermeyer, Gregor Theilmeier, Kira Jahn, Bianca Sahlmann, Kai Johanning, Klaudiusz Suchodolski

Publikováno v: Anesthesia & Analgesia. 124:1091-1098

BACKGROUND Hemorrhage is the most important complication of antithrombotic therapy with P2Y12 receptor blockers. The administration of platelet concentrates (PCs) and von Willebrand factor (vWF) concentrates are common procedures to normalize impaire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679c575762d0557f5d0437d13c223855
https://doi.org/10.1213/ane.0000000000001903

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Acetaminophen-induced liver injury is mediated by the ion channel TRPV4

Autor: Mohammad Ibrahim Khalil, Mirjam Eberhardt, Andreas Leffler, Christine Herzog, Florian W. R. Vondran, Linus Risser, Faikah Gueler, Frank Echtermeyer, Matthias Engel

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(9)

Overdosing of the analgesic acetaminophen (APAP) is one of the most common causes for acute liver failure in modern countries. Although the exact molecular mechanisms mediating hepatocellular necrosis are still elusive, it is preceded by oxidative st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d587c3a9551de91c9bec7544a1bdd69f
https://pubmed.ncbi.nlm.nih.gov/31207191

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