Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Frank E. Greene"'
Publikováno v:
Biochemical Pharmacology. 49:1091-1098
The response of an SV40-immortalized hepatocyte cell line (CWSV-1) derived from adult male rat hepatocytes to human growth hormone (hGH) was investigated. CWSV-1 cells, which have been characterized extensively, retain certain differentiated function
Autor:
Frank E. Greene, Svetozar Grgurevich
Publikováno v:
Pharmacology. 51:13-23
Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hep
Publikováno v:
Endocrinology. 99:1353-1362
Administration of testosterone for 6 days to intact female and castrate male BALB/cJ mice stimulated hepatic microsomal ethylmorphine N-demethylase activity and cytochrome P-450 content by 50–75%. Testosterone also stimulated hepatic microsomal NAD
Autor:
Alain Kervran, Susan J. Vannucci, Margaret K. McLaughlin, Marc J. Jaeger, L.C.T. Carlsson, Jane E. Howard, Jean-Pierre Geloso, Y.S. Shin-Buehring, B. Bernard, P. Rahm, David Sadava, Robert C. Vannucci, Robert C. McEvoy, J. Schaub, Elizabeth E. Nardis, Charles M. Haberkern, Goran Enhorning, Paul G.R. Harding, Jan Earl Herd, Jean Girard, A.F. Burton, Donald V. Eitzman, M. Osang, Frank E. Greene, Ernest F Beale, Jill Stewart-DeHaan, Nicole Freund, Roger Assan, Iii Philips Joseph B., Börje W. Karlsson, Thomas N. Hansen, Michael A. Bressack, Fred Possmayer, Katherine L. Madson, Lesley M. Tye, Gary K. Oakes, LeRoy Metcalfe, M. Dallinger, Ronald A. Chez, K. Elliott, Björn Weström, Adrian M. Walker, Susan C. Brennan, Richard A. Ehrenkranz, Richard D. Bland
Publikováno v:
Neonatology. 38:I-IV
Autor:
Frank E. Greene, Bengt Jernström
Publikováno v:
Cancer Letters. 8:235-239
It has been reported human lung has cytochrome P-450 dependent mono-oxygenase activity which is necessary for the formation of mutagneic and carcinogenic metabolities of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene. We now report epoxide
Inhibition of p-Aminophenol Metabolism: a Possible Mechanism of Enhancement of Aniline Hydroxylation
Publikováno v:
Pharmacology. 21:153-160
The p-hydroxylation of aniline has been traditionally determined by measurement of p-aminophenol (PAP) formation. Comparison of isotopic and colorimetric procedures indicate that the actual amount of aniline metabolized exceeds the among of PAP recov
Publikováno v:
Toxicology and Applied Pharmacology. 37:29-37
The administration of a single oral dose of dieldrin, 40 mg/kg, or the feeding of a diet containing 50 ppm of dieldrin for up to 8 weeks to male and female rats produced changes in plasma and liver esterases that were dependent on the type of esteras
Publikováno v:
Biochemical Genetics. 12:295-308
Differences in the electrophoretic pattern of hepatic microsomal esterases have been observed in the outbred Sprague-Dawley strain of albino rats. Two distinct phenotypes occurred which were characterized by either the presence or the near absence of
Autor:
Frank E. Greene, Michael A. Zemaitis
Publikováno v:
Toxicology and Applied Pharmacology. 48:343-350
The effects of tetramethylthiuram disulfide (TMTDS) and dimethyldithiocarbamate (DMDTC) on hepatic microsomal drug metabolism were studied after in vivo administration to male rats (1 g/kg, po) and after in vitro addition of the compounds to control
Autor:
Steven R. Wagner, Frank E. Greene
Publikováno v:
Toxicology and Applied Pharmacology. 43:45-55
Dieldrin-Induced Alterations in Biogenic Amine Content of Rat Brain. Wagner, S. R. and Greene, F. E. (1978). Toxicol. Appl. Pharmacol. 43, 45–55. Male and female Sprague-Dawley rats were exposed acutely and chronically to dieldrin. The effects of t