Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Frank Deyounks"'
Autor:
David A Garber, James Mitchell, Debra Adams, Patricia Guenthner, Frank Deyounks, Shanon Ellis, Kristen Kelley, Ryan Johnson, Charles Dobard, Walid Heneine, Janet McNicholl
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194837 (2018)
Penile acquisition of HIV infection contributes substantially to the global epidemic. Our goal was to establish a preclinical macaque model of penile HIV infection for evaluating the efficacy of new HIV prevention modalities. Rhesus macaques were cha
Externí odkaz:
https://doaj.org/article/0085ca4002db4cf1a87aa03e66db3fb0
Autor:
Tyana Singletary, Karen W. Buckheit, Chuong Dinh, Lara E. Pereira, Amy Martin, Angela Holder, Anthony S. Ham, Robert W. Buckheit, Janet M. McNicholl, David F. Katz, Frank Deyounks, James M. Smith
Publikováno v:
Drug Delivery and Translational Research. 8:1180-1190
This study evaluated effects of differing gel volumes on pharmacokinetics (PK). IQB4012, a gel containing the non-nucleoside reverse transcriptase inhibitor IQP-0528 and tenofovir (TFV), was applied to the pigtailed macaque vagina and rectum. Vaginal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abf398aff99e17cc8cf7fb379491c59
https://doi.org/10.1007/s13346-018-0538-0
https://doi.org/10.1007/s13346-018-0538-0
Autor:
Mara Sterling, William Spreen, J. Gerardo García-Lerma, Angela Holder, Walid Heneine, George Khalil, Natalia Makarova, Jonathan Lipscomb, Charles Dobard, Frank Deyounks, James Mitchell, Kenji Nishiura, Chuong Dinh, David W. Garber
Publikováno v:
The Journal of infectious diseases. 222(3)
We used a novel penile simian-human immunodeficiency virus (SHIV) transmission model to investigate whether long-acting cabotegravir (CAB LA) prevents penile SHIV acquisition in macaques. Twenty-two macaques were exposed to SHIV via the foreskin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c0f29e28586878ca2123bb99b025a2
https://pubmed.ncbi.nlm.nih.gov/32128569
https://pubmed.ncbi.nlm.nih.gov/32128569
Autor:
Darius Babusis, Ryan Johnson, Walid Heneine, Christian Callebaut, Angela Holder, George Khalil, Yeojin Park, Mian-er Cong, Chuong Dinh, James F. Rooney, J. Gerardo García-Lerma, Ivana Massud, Jonathan Lipscomb, Scott McCallister, Kenji Nishiura, Frank Deyounks, Susan Ruone, Yi Pan
Publikováno v:
The Journal of infectious diseases. 220(11)
BackgroundTenofovir alafenamide (TAF)-based regimens are being evaluated for pre-exposure prophylaxis (PrEP). We used a macaque model of repeated exposures to simian human immunodeficiency virus (SHIV) to investigate whether TAF alone or the combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41135b7bfcd6ff628868ac7b5d3ec4cb
https://pubmed.ncbi.nlm.nih.gov/31362305
https://pubmed.ncbi.nlm.nih.gov/31362305
Autor:
Andre Hopkins, Sundaram A. Vishwanathan, Jana M. Ritter, Lara E. Pereira, Janet M. McNicholl, Samantha S. Katz, Chunxia Zhao, Yetunde F Fakile, James Mitchell, Ellen N. Kersh, Allan Pillay, Frank Deyounks, Cassandra Tansey
Among men who have sex with men (MSM), those with a diagnosis of syphilis or other rectal sexually transmitted infections (STIs) are at a higher risk for human immunodeficiency virus acquisition, which is concerning given the large increase in recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7d8625543026b2f7bf62a5214a7310
https://europepmc.org/articles/PMC5939619/
https://europepmc.org/articles/PMC5939619/
Autor:
Charles Dobard, Debra R. Adams, David A. Garber, Janet M. McNicholl, Walid Heneine, Shanon Ellis, Frank Deyounks, Patricia C. Guenthner, Ryan Johnson, Kristen Kelley, James Mitchell
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0194837 (2018)
PLoS ONE, Vol 13, Iss 3, p e0194837 (2018)
Penile acquisition of HIV infection contributes substantially to the global epidemic. Our goal was to establish a preclinical macaque model of penile HIV infection for evaluating the efficacy of new HIV prevention modalities. Rhesus macaques were cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605f97221899407be616a7096b3f2577
https://pubmed.ncbi.nlm.nih.gov/29584769
https://pubmed.ncbi.nlm.nih.gov/29584769
Autor:
Christi Philips, Cheng Y. Chen, Jana M. Ritter, Sundaram A. Vishwanathan, Ellen N. Kersh, Monica Morris, Janet M. McNicholl, Kristen Kelley, Chunxia Zhao, George Khalil, Frank Deyounks, Rachael D. Aubert
Publikováno v:
Sexually transmitted diseases. 44(9)
Background Sustained genital tract inflammation caused by sexually transmitted infections (STIs) is known to increase risk of vaginal human immunodeficiency virus (HIV) infections but, to our knowledge, there are no nonhuman primate studies that have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9533843738a5ad7fb4b4351b26684259
https://pubmed.ncbi.nlm.nih.gov/28809773
https://pubmed.ncbi.nlm.nih.gov/28809773
Autor:
James Mitchell, Katherine Butler, Harlan D. Caldwell, Dorothy L. Patton, John R. Papp, Christi Phillips, Tara Henning, Frank Deyounks, Carol E. Farshy, Gail L. Sturdevant, Ellen N. Kersh, Shanon Ellis, Janet M. McNicholl
Publikováno v:
Journal of Medical Primatology. 43:135-143
Background Rectal sexually transmitted infections (STIs) may increase HIV susceptibility in men who have sex with men (MSM), and Chlamydia trachomatis is prevalent among HIV-positive MSM. To study STIs and HIV infection in MSM, we first evaluated whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e9739f208cca0ebdd259365c8bbce7
https://doi.org/10.1111/jmp.12103
https://doi.org/10.1111/jmp.12103
Autor:
Walid Heneine, J. Gerardo García-Lerma, Adrian S. Ray, James Mitchell, Ivana Massud, James F. Rooney, Darius Babusis, Michael D. Miller, Frank Deyounks
Publikováno v:
The Journal of infectious diseases. 214(7)
Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir that efficiently delivers tenofovir diphosphate to lymphoid cells following oral administration. We investigated whether the combination of TAF and emtricitabine (FTC) could prevent simian/h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d41f27d617e94250c467ae89bf970c
https://pubmed.ncbi.nlm.nih.gov/27465645
https://pubmed.ncbi.nlm.nih.gov/27465645
Autor:
James M. Smith, Pedro M. M. Mesquita, Tyana Singletary, Lara E. Pereira, Frank Deyounks, Robert W. Buckheit, Amy Martin, Anthony S. Ham, Karen W. Buckheit, Janet M. McNicholl
Publikováno v:
Antimicrobial agents and chemotherapy. 60(3)
We evaluated the in vivo pharmacokinetics and used a complementary ex vivo coculture assay to determine the pharmacodynamics of IQB3002 gel containing 1% IQP-0528, a nonnucleoside reverse transcriptase inhibitor (NNRTI), in rhesus macaques (RM). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15636e6b39c6786b0f32ccf30582d38f
https://pubmed.ncbi.nlm.nih.gov/26666935
https://pubmed.ncbi.nlm.nih.gov/26666935